Navigation Links
New details on the molecular machinery of cancer
Date:2/11/2013

problems with the EGFR. However, despite its well-established links to cancer, EGFR activation has only been partially understood.

"As a member of the large class of cell surface receptors known as receptor tyrosine kinases, EGFR features a ligand-binding domain on its extracellular side and a kinase domain on its intracellular side," Groves says. "The text-book explanation for EGFR activation is that the binding of EGFR's ligand, EGF, to its extracellular side induces dimerization of the receptor, which in turn brings together the kinase domains on the intracellular sides of the dimer, allowing them to phosphorylate one another."

Groves says while the picture is accurate, it is an oversimplification of the mechanics behind the process because isolated intracellular kinase domains in solution can be active on their own at relatively low concentration without EGF ligand-induced dimerization. Dimerization is the combining of two identical molecules into a single compound molecule.

Measuring autophosphorylation as a function of EGFR surface density in cells, Groves, Kuriyan and their colleagues found that structural coupling between the EGFR transmembrane helix and extracellular juxtamembrane modules in addition to EGF ligand-engagement is required for EGFR activation. This structural coupling permits dimerization to take place in the presence of the EGF ligand.

"The un-ligated EGFR sits in a structural configuration that prevents the intracellular kinase domains from being able to reach each other," Groves says. "When the EGF ligand binds, this restraint is removed, dimerization occurs, and one kinase phosphorylates the other."

The inclusion by Groves and his colleagues of time-resolved fluorescence spectroscopy on living cells is another new advance in bringing a quantitative approach to the biological sciences. By combining picosecond light pulses from two different colors of lasers into a single beam, then genetically
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Researchers unveil molecular details of how bacteria propagate antibiotic resistance
2. Stanford/Intel study details power of new chip to diagnose disease, analyze protein interactions
3. Study details bullying involvement for adolescents with autism spectrum disorder
4. Report Details Start of Steroid Meningitis Outbreak
5. MyPuress Releases Details About Groundbreaking New Product
6. IOM report details strategy for monitoring safety of childhood immunization schedule
7. Institute of Medicine report details for monitoring safety of childhood immunization schedule
8. Scans Show Details of Damage to Soldiers With Head Injuries
9. Coordinating the circadian clock: Molecular pair controls time-keeping and fat metabolism
10. Molecular probes identify changes in fibronectin that may lead to disease
11. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New details on the molecular machinery of cancer
(Date:7/11/2014)... 2014 Alliance for Cancer Gene ... dedicated exclusively to cell and gene therapies for ... joined the organization as Senior Development Officer. , ... experience securing gifts and addressing influential donors. Prior ... Director for NewYork Presbyterian Hospital/Columbia University Medical Center, ...
(Date:7/11/2014)... As reported by the New York Times ... number of severe adverse events such as renal failure, ... from the highly-promoted and costly immune-system drug, Acthar, have ... , a regulatory filing revealed that the total number ... 14% of prescriptions, up from 9.1% in 2011. Specifically, ...
(Date:7/11/2014)... surgery to repair damage to the anterior cruciate ligament (ACL) ... -- could increase a young athlete,s risk for further injuries, ... patients, aged 8 to 16, who had ACL reconstruction surgery. ... after their injury, 37 had surgery six to 12 weeks ... after their injury. The youngsters who had surgery later ...
(Date:7/11/2014)... 2014 Riverside Health System became the first ... Virginia in late 2012 and now, in partnership with Williamsburg ... throughout the Williamsburg and Newport News region. , Also known ... benefits to independent older adults who wish to remain in ... net of continuing care services as well as control over ...
(Date:7/11/2014)... unravel mechanisms that guide function and differentiation of blood ... including our immune system. The study of human blood ... found in the bone marrow in specialized "niches" that ... group of scientists from Dresden led by stem cell ... to generate a mouse model that supports the transplantation ...
Breaking Medicine News(10 mins):Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 2Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 3Health News:Acthar’s Deadly Adverse Events Revealed 2Health News:Acthar’s Deadly Adverse Events Revealed 3Health News:Delaying Kid's Knee Surgery Could Be a Bad Play, Study Finds 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 3Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 4Health News:Opening-up the stem cell niche 2
... and ISMANING, Germany, Oct. 17 /PRNewswire-FirstCall/,-- XIRING ... security solutions,for remote transactions, and SCM Microsystems ... of solutions that open the Digital,World, today ... eHealth,smart card terminals for the new generation ...
... today filed an amicus brief on behalf of ten ... RU-486., AUL President Dr. Charmaine Yoest stated, "RU-486 ... women,s lives. We must put a stop to,abortionists, dangerous, ... in the right direction, and as we argue in ...
... into any grocery store,and there,s likely to be ... struggle with mindless eating have already begun to ... people find that Halloween spurs,a particularly tough time ... coming, it,only becomes more challenging. Dieters, mindless eaters, ...
... SPRINGFIELD, Mass., Oct. 16 With a combination ... become its hallmark, Massachusetts Mutual Life Insurance Company,(MassMutual) ... to the cause,of Breast Cancer Awareness Month., ... contribute tens of thousands,of dollars to cancer research, ...
... Alert Urges HR/Leadership Development to Implement Post-Crash Development Programs with ... ... Gainesville, FL (PRWEB) October 16, 2008 -- ... and how human resources and leadership development can quickly ...
... researcher, clinical nutritionist and women,s health practitioner, has ... Revitalizer, designed to bring back thicker, fuller hair ... Nails Revitalizer is available exclusively through Doctors, Preferred, ... one of the largest North American direct-mail supplement ...
Cached Medicine News:Health News:XIRING and SCM Microsystems Jointly Develop Mobile Terminals for German eHealth Market 2Health News:XIRING and SCM Microsystems Jointly Develop Mobile Terminals for German eHealth Market 3Health News:Ohio's Regulation of RU-486 Clear and Constitutional, Should Be Upheld Argues AUL in Brief Filed Before Ohio Supreme Court 2Health News:A Mindful Chocolate Meditation 2Health News:Donations, Education, and People-Power Mark MassMutual Breast Cancer Awareness Month Efforts 2Health News:Donations, Education, and People-Power Mark MassMutual Breast Cancer Awareness Month Efforts 3Health News:Donations, Education, and People-Power Mark MassMutual Breast Cancer Awareness Month Efforts 4Health News:Perth Leadership Institute Issues Alert on the Post-Crash Environment Facing HR/Leadership Development 2Health News:Perth Leadership Institute Issues Alert on the Post-Crash Environment Facing HR/Leadership Development 3Health News:Dr. Lark Creates Nutritional Supplement to Restore Thick Hair and Strong Nails 2Health News:Dr. Lark Creates Nutritional Supplement to Restore Thick Hair and Strong Nails 3
(Date:7/10/2014)...   LabStyle Innovations Corp . (OTCQB:DRIO), developer of ... appointment of Professor Richard B. Stone ... Directors. Prof. Stone brings over forty-five ... as an entrepreneur, venture capitalist public, company officer ... He currently serves on the board of directors ...
(Date:1/15/2014)... Jan. 15, 2014 Most osteoporosis patients want a ... recent online survey* sponsored by Mission Pharmacal Company. The ... Osteoporosis Foundation online support community, revealed that 74 percent ... comes in a form other than a pill or ...
(Date:1/15/2014)... LAWRENCEVILLE, N.J. , Jan. 15, 2014  Celsion Corporation (the ... it has received commitments from institutional investors to purchase ... common stock in an at-the-market registered direct offering, led ... Company entered into definitive purchase agreements with these investors ...
Breaking Medicine Technology:LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... Reportlinker.com announces that a new market research ... Advanced Drug Delivery Markets (Liposomes, Polymers and ... Drug delivery is evolving at a ... discovered frequently. Advanced drug delivery deals with developing ...
... Jan. 11, 2011 Reportlinker.com announces that a ... catalogue: France Pharmaceutical Market Overview ... http://www.reportlinker.com/p0360215/France-Pharmaceutical-Market-Overview-–--Austerity-measures-will-impact-pharmaceutical-market-growth.html ... pharma market in France was valued at $38.8bn ...
Cached Medicine Technology:Reportlinker Adds Advanced Drug Delivery Markets (Liposomes, Polymers and Monoclonal Antibodies) 2Reportlinker Adds Advanced Drug Delivery Markets (Liposomes, Polymers and Monoclonal Antibodies) 3Reportlinker Adds France Pharmaceutical Market Overview - Austerity measures will impact pharmaceutical market growth 2
... an innovative, quick and easy automated ... 60% less space on your laboratory ... this amazingly easy-to-use, one-hand system, you ... whole range of Diamond Tips. All ...
200 L, Racked, Pre-sterilized, 96 tips/rack, clear Recommended for 20, 25, 50, 100 and 200 L pipettes. Can also be used with 300 L pipettes when pipetting 200 L or less....
MBP's equivalent to the "Universal Yellow" tip, this 200 L tip utilizes a MicroPoint design for accurate sample handling. 10 L Ref. mark....
For the quantitative determination of luteinizing hormone (LH) concentration in human serum....
Medicine Products: