Navigation Links
New details on the molecular machinery of cancer
Date:2/11/2013

problems with the EGFR. However, despite its well-established links to cancer, EGFR activation has only been partially understood.

"As a member of the large class of cell surface receptors known as receptor tyrosine kinases, EGFR features a ligand-binding domain on its extracellular side and a kinase domain on its intracellular side," Groves says. "The text-book explanation for EGFR activation is that the binding of EGFR's ligand, EGF, to its extracellular side induces dimerization of the receptor, which in turn brings together the kinase domains on the intracellular sides of the dimer, allowing them to phosphorylate one another."

Groves says while the picture is accurate, it is an oversimplification of the mechanics behind the process because isolated intracellular kinase domains in solution can be active on their own at relatively low concentration without EGF ligand-induced dimerization. Dimerization is the combining of two identical molecules into a single compound molecule.

Measuring autophosphorylation as a function of EGFR surface density in cells, Groves, Kuriyan and their colleagues found that structural coupling between the EGFR transmembrane helix and extracellular juxtamembrane modules in addition to EGF ligand-engagement is required for EGFR activation. This structural coupling permits dimerization to take place in the presence of the EGF ligand.

"The un-ligated EGFR sits in a structural configuration that prevents the intracellular kinase domains from being able to reach each other," Groves says. "When the EGF ligand binds, this restraint is removed, dimerization occurs, and one kinase phosphorylates the other."

The inclusion by Groves and his colleagues of time-resolved fluorescence spectroscopy on living cells is another new advance in bringing a quantitative approach to the biological sciences. By combining picosecond light pulses from two different colors of lasers into a single beam, then genetically
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Researchers unveil molecular details of how bacteria propagate antibiotic resistance
2. Stanford/Intel study details power of new chip to diagnose disease, analyze protein interactions
3. Study details bullying involvement for adolescents with autism spectrum disorder
4. Report Details Start of Steroid Meningitis Outbreak
5. MyPuress Releases Details About Groundbreaking New Product
6. IOM report details strategy for monitoring safety of childhood immunization schedule
7. Institute of Medicine report details for monitoring safety of childhood immunization schedule
8. Scans Show Details of Damage to Soldiers With Head Injuries
9. Coordinating the circadian clock: Molecular pair controls time-keeping and fat metabolism
10. Molecular probes identify changes in fibronectin that may lead to disease
11. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New details on the molecular machinery of cancer
(Date:7/30/2014)... Francisco, CA (PRWEB) July 30, 2014 ... capture and physician communication, launched an Observation Result ... in the hospital. pMD’s cardiology customers are using ... optimize revenue for their test interpretations for electrocardiograms, ... interprets tests in the hospital, the cardiology system ...
(Date:7/30/2014)... Regents Health Resources, a consulting firm traditionally ... care industry veteran Daryl Demonbreun and former St. Thomas ... company’s ambitious plans to grow into a full-service health ... along at a steady pace for nearly 20 years, ... says Bob Maier, founder and chief executive officer of ...
(Date:7/29/2014)... July 30, 2014 VisitandCare.com ... have been added to the company’s exclusive network to ... out of joint efforts — as top fertility clinics ... to offer affordable, state-of-the-art, and successful IVF treatments. , ... with a comprehensive study by professionals at VisitandCare.com. The ...
(Date:7/29/2014)... a well-known wedding dress manufacturer and retailer, has unveiled its ... this, it has announced that all of them are provided ... its old and new clients may now access the big ... are pleased to release the new collection of satin bridal ... amazing items. It is true that our satin bridal gowns ...
(Date:7/29/2014)... Phytceramides are a natural anti-aging tool for improving skin, ... , Today is the last day to nab a free download ... The book is also sold in hard copy. , "I am ... Phytoceramides were so new and very unknown in the U.S. ... says Kathy Heshelow, founder of Sublime Beauty®. "It is an easy ...
Breaking Medicine News(10 mins):Health News:pMD Automates Cardiology Charge Capture: Low-Reimbursement Services Become Profitable 2Health News:pMD Automates Cardiology Charge Capture: Low-Reimbursement Services Become Profitable 3Health News:Sferrella and Demonbreun Join Regents Health Resources 2Health News:Top European Fertility Clinics Join VisitandCare.com 2Health News:Top European Fertility Clinics Join VisitandCare.com 3Health News:Top European Fertility Clinics Join VisitandCare.com 4Health News:Cheap Satin Bridal Gowns Recently Provided By Well-known Supplier iFitDress.com 2Health News:Last Day New Book Is Available at No Cost: Phytoceramides, Anti Aging At Its Best by Sublime Beauty Founder® Kathy Heshelow 2Health News:Last Day New Book Is Available at No Cost: Phytoceramides, Anti Aging At Its Best by Sublime Beauty Founder® Kathy Heshelow 3
... , MINNEAPOLIS, Aug. 31 The August edition ... Lotion can play in managing dry skin associated with the genetic skin ... that 40% of women have symptoms, like little red bumps on their ... , To help individuals find out more about dry ...
... , Safety tips also offered as fires threaten ... American Red Cross is on the scene offering evacuees a safe place ... scorch thousands of acres. Overnight, nearly 200 people took refuge from the ... (Logo: http://www.newscom.com/cgi-bin/prnh/20090108/RedCrossLOGO ) , , "If ...
... find tumors during minimally invasive surgery, researchers say , ... arm that can gently "feel" for cancerous tumors during ... , The device, invented at the University of Western ... will help surgeons better isolate tumors from softer surrounding ...
... , , Union members to ... , , LOS ANGELES and OAKLAND, Calif., Aug. ... California will picket outside their work sites for the next five weeks ... pickets will take place from 11:30 a.m. to 1:30 p.m. on Tuesday, ...
... , , , COCONUT ... ) the leading single source telehealth solution provider and ... savings accounts for unions, employers, and brokers, announced today that ... corporations and unions, will not only revolutionize the delivery of ...
... NEW YORK, Aug. 31 You may guess by reading ... a rare breed. He,s also a rare blood type: O-positive, "Code ... , , Make that a VERY dedicated blood donor: ... donation, the most on record for New York Blood Center (NYBC) and ...
Cached Medicine News:Health News:Family Circle Magazine Features AmLactin(R) in Article on Managing Dry Skin Associated With Keratosis Pilaris 2Health News:Red Cross Shelters Wildfire Evacuees 2Health News:Red Cross Shelters Wildfire Evacuees 3Health News:New Robotic Arm Has Softer Surgical Touch 2Health News:Kaiser Workers' Statewide Campaign Starts Tuesday 2Health News:e-Telmed, Inc., the Leading Telehealth Solution Provider, Signs Exclusive Agreement with Synergistic Healthcare 2Health News:This Guy's Got Blood, and Heart -- At 320 and Counting, Al Fischer Sets Record for Blood Donations 2Health News:This Guy's Got Blood, and Heart -- At 320 and Counting, Al Fischer Sets Record for Blood Donations 3Health News:This Guy's Got Blood, and Heart -- At 320 and Counting, Al Fischer Sets Record for Blood Donations 4
(Date:7/29/2014)... ST. LOUIS, July 29, 2014  Express Scripts Holding ... quarter net income attributable to Express Scripts stockholders of ... per diluted share, as detailed in Table 4, was ... "We are well positioned to serve our clients with ... and to improve the health outcomes of our members," stated ...
(Date:7/29/2014)... 29, 2014 Regado Biosciences, Inc. (Nasdaq: ... Phase 3 clinical development of Revolixys™ Kit (previously known ... today announced that it will hold a conference call ... at 8:30 a.m. EDT to discuss its second quarter ... participants and investors may access the conference call by ...
(Date:7/29/2014)... VIEW, Calif. , July 29, 2014  Alexza ... that it is participating in two healthcare conferences during ... Conference and the Morgan Stanley Global Healthcare 2014 Conference. ... Morgan Stanley Conference.  The details on each event are ... Conference, Monday, August 11, 2014 in Boston ...
Breaking Medicine Technology:Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 2Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 3Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 4Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 5Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 6Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 7Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 8Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 9Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 10Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 11Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 12Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 13Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 14Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 15Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 16Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 17Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 18Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 19Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 20Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 21Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 22Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 23Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 24Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 25Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 26Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 27Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 28Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 29Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 30Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 31Regado Biosciences to Provide Second Quarter 2014 Financial Results and Corporate Highlights 2Regado Biosciences to Provide Second Quarter 2014 Financial Results and Corporate Highlights 3Alexza Pharmaceuticals Announces Participation in Upcoming Investor Conferences 2Alexza Pharmaceuticals Announces Participation in Upcoming Investor Conferences 3
... Prep Swabsticks are saturated with a 10% ... available iodine. Povidone Iodine is virtually non-irritating ... is also non-staining to the skin or ... microbes on contact; they are sturdy tools ...
BD Persist Plus protective barrier provides a one-step antimicrobial barrier with minimum of 1% chlorhexidine with Up to 7-day antimicrobial effectiveness....
The design of the new ChloraPrep swabstick applicator provides significant improvement in performance over traditional swabsticks....
... Swabsticks are packaged in easy open, single-use ... saturated with precisely the correct amount of ... the safest possible product for the patient. ... an excellent combination of ethyl alcohol and ...
Medicine Products: