Navigation Links
New details on the molecular machinery of cancer
Date:2/11/2013

Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.

"The more we understand about EGFR and the complex molecular machinery involved in the growth and proliferation of cells, the closer we will be to developing new and more effective ways to cure and treat the many different forms of cancer," says chemist Jay Groves, one of the leaders of this research. "Through a tour-de-force of quantitative biology techniques that included cutting edge time-resolved fluorescence spectroscopy in living cells, Nuclear Magnetic Resonance, and computational modeling, we've determined definitively how EGFR becomes activated through to its epidermal growth factor (EGF) ligand."

Groves, who holds joint appointments with Berkeley Lab's Physical Biosciences Division and UC Berkeley's Chemistry Department, and is also a Howard Hughes Medical Institute (HHMI) investigator is one of two corresponding authors of a paper in the journal Cell that describes this research. The paper is titled "Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor." The other corresponding author is John Kuriyan, who also holds joint appointments with Berkeley Lab, UC Berkeley and HHMI.

In high school biology classes we learn that genes contain coded instructions that are translated into the assembly of specific proteins. Many proteins, however, must be activated by post-translational processes such as autophosphorylation, the addition of phosphate. Protein activation can impact many important cellular processes including proliferation, differentiation and migration. Cancer is essentially a case of these cellular functions gone wild, often the result of
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Researchers unveil molecular details of how bacteria propagate antibiotic resistance
2. Stanford/Intel study details power of new chip to diagnose disease, analyze protein interactions
3. Study details bullying involvement for adolescents with autism spectrum disorder
4. Report Details Start of Steroid Meningitis Outbreak
5. MyPuress Releases Details About Groundbreaking New Product
6. IOM report details strategy for monitoring safety of childhood immunization schedule
7. Institute of Medicine report details for monitoring safety of childhood immunization schedule
8. Scans Show Details of Damage to Soldiers With Head Injuries
9. Coordinating the circadian clock: Molecular pair controls time-keeping and fat metabolism
10. Molecular probes identify changes in fibronectin that may lead to disease
11. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New details on the molecular machinery of cancer
(Date:9/1/2015)... ... , ... Elizabeth Callahan, MD, founder and medical director of SkinSmart Dermatology® ... RADIESSE® filler treatment for volume loss in the hands. RADIESSE provides an immediate volumizing ... hands, delivering smooth, natural-looking results that can last up to one year in most ...
(Date:9/1/2015)... ... , ... A new episode of “Voices In America”, hosted by famous actor ... of arthritis. There are over 100 different types of arthritis. One of the most ... an effort to shed light on this important topic. , Anyone who is nearing ...
(Date:9/1/2015)... ... September 01, 2015 , ... Specialty ... newly updated International Audit Protocol Consortium (IAPC) EHS audit protocol for the European ... the scope of their EHS regulatory obligations and rapidly collect, share, archive, and ...
(Date:8/31/2015)... (PRWEB) , ... September 01, 2015 , ... ... professionals, today announced the release of ten hours of new premium on-demand video ... of Certification members. , Athletic Trainers certified before 2014 must complete 50 CEUs ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... industry, released their latest predictive use case focused on helping hospital perform under ... Under this program, hospital payments are adjusted based on performance across four domains ...
Breaking Medicine News(10 mins):Health News:SkinSmart Dermatology in Sarasota is Now Offering RADIESSE to Rejuvenate Hands 2Health News:SkinSmart Dermatology in Sarasota is Now Offering RADIESSE to Rejuvenate Hands 3Health News:Specialty Technical Publishers (STP) and Specialty Technical Consultants(STC) Publish Environmental, Health & Safety (EHS) Audit Protocol for the European Union 2Health News:Specialty Technical Publishers (STP) and Specialty Technical Consultants(STC) Publish Environmental, Health & Safety (EHS) Audit Protocol for the European Union 3Health News:Specialty Technical Publishers (STP) and Specialty Technical Consultants(STC) Publish Environmental, Health & Safety (EHS) Audit Protocol for the European Union 4Health News:Evidence Based Practice Courses: CEUs For Athletic Trainers Just Released 2Health News:Jvion Releases Value-Based Purchasing Predictive Use Case 2
... children with tooth decay may be more likely to be ... weight, are more likely to consume too many calories, a ... The Endocrine Society,s 92nd Annual Meeting in San Diego. ... decay and obesity in preschoolers," the study,s lead author, Kathleen ...
... at increased risk of obesity, but a new study shows ... preschoolers and their parents helps the children reduce body fat ... The Endocrine Society,s 92nd Annual Meeting in San Diego. ... obesity epidemic, the study,s lead author Jardena Puder, MD, said. ...
... , ... Angeles dentist, is proud to announce the opening of his new office in North Hollywood. Many ... staff in North Hollywood, CA. , ... June 22, 2010 -- Dr. Bijan Afar, well-respected Los Angeles dentist , is proud to ...
... ... million gift to help fund the construction of its new home at the UCSF Mission ... ... gift to help fund the construction of its new home at the UCSF Mission Bay ...
... ... announced the following organizations will use SeeMyRadiology.com for medical image exchange with outside ... ... ( http://www.SeeMyRadiology.com ), Accelarad’s online medical image cloud computing service, today announced the ...
... ... the organization targets an audience of teens and young adults in an effort to empower ... cancer. , ... 22, 2010 -- Kids Into Safe Skin (K.I.S.S) announced today the official launch of its ...
Cached Medicine News:Health News:Study shows a possible link between preschoolers' cavities and excess body fat 2Health News:Lifestyle intervention reduces preschoolers' body fat, improves fitness 2Health News:Trusted Los Angeles Dentist, Dr. Bijan Afar, is Now Practicing in Hollywood Area 2Health News:Trusted Los Angeles Dentist, Dr. Bijan Afar, is Now Practicing in Hollywood Area 3Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 2Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 3Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 4Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 5Health News:Accelarad Announces Six New SeeMyRadiology.com Customers Seeking Fast, Secure and Innovative Medical Image Exchange Solution 2Health News:Kids Into Safe Skin (K.I.S.S) Officially Launches Today with a Mission to Create Awareness About Skin Cancer Detection and Prevention 2Health News:Kids Into Safe Skin (K.I.S.S) Officially Launches Today with a Mission to Create Awareness About Skin Cancer Detection and Prevention 3Health News:Kids Into Safe Skin (K.I.S.S) Officially Launches Today with a Mission to Create Awareness About Skin Cancer Detection and Prevention 4
(Date:9/1/2015)... MOUNTAIN VIEW, Calif. , Sept. 1, ... of the cardiovascular image management market, Frost ... with the 2015 European Frost & Sullivan ... Netherlands -based PMI has designed innovative ... product lines—which deliver precise and reproducible quantitative ...
(Date:9/1/2015)... 1, 2015  Abbott (NYSE: ABT ) announced today ... randomized trial comparing the safety and effectiveness of Abbott,s ... , Abbott,s market-leading, permanent drug eluting stent. The trial ... and enrolled 400 people with coronary artery ... results will be featured at a late-breaking session today ...
(Date:9/1/2015)... September 1, 2015 BerGenBio AS ... announces that it has appointed Hilde Furberg ... to its Board of Directors, effective immediately. ... experience in pharma and biotech and is currently Senior ... company. Previously her role was Vice President and General ...
Breaking Medicine Technology:Frost & Sullivan Applauds Pie Medical Imaging for Highly Innovative Quantitative Software for Cardiovascular Diagnosis 2Frost & Sullivan Applauds Pie Medical Imaging for Highly Innovative Quantitative Software for Cardiovascular Diagnosis 3Frost & Sullivan Applauds Pie Medical Imaging for Highly Innovative Quantitative Software for Cardiovascular Diagnosis 4Frost & Sullivan Applauds Pie Medical Imaging for Highly Innovative Quantitative Software for Cardiovascular Diagnosis 5Abbott Announces Positive Results of Its Naturally Dissolving Stent from ABSORB Japan Study 2Abbott Announces Positive Results of Its Naturally Dissolving Stent from ABSORB Japan Study 3Abbott Announces Positive Results of Its Naturally Dissolving Stent from ABSORB Japan Study 4BerGenBio Appoints Non-Executive Directors 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: