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New depression treatments reported
Date:2/14/2014

lls in the hippocampus begin to atrophy. (The hippocampus is a part of the brain involved with emotions, learning and memory formation.)

The new depression theories "should not be viewed as separate entities because they are highly interconnected," Rao and Alderson write. "Integrating them provides for a more expansive understanding of the pathophysiology of depression and biomarkers that are involved."

Such biomarkers are molecules in the body that can be indicators of depression. The authors identify more than a dozen potential biomarkers depression, including monoamine regulators; proinflammatory cytokines and other inflammatory mediators; mediators of glutaminergic activity and GABAergic activity; and regulators of neurogenesis.

Depression treatments currently offered or on the horizon include corticotropin-releasing hormone antagonists; dexamethasone; partial adrenalectomy; long-term cognitive behavioral therapy; ketamine and other NMDA antagonists; benzodiazepines; anesthetics; deep brain stimulation; transcranial magnetic stimulation; exogenous brain-derived neurotrophic factor; selective serotonin reuptake inhibitors; tricyclic antidepressants; atypical antidepressants; reduction in inflammation; and anti-inflammatory drugs.

It can take several months to recover from depression. Thus, Rao and Alderson write, current depression treatment programs that average six weeks "are not long enough for adequate recovery."


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Contact: Jim Ritter
jritter@lumc.ede
708-216-2445
Loyola University Health System
Source:Eurekalert

Page: 1 2

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