Navigation Links
New depression treatments reported

MAYWOOD, IL New insights into the physiological causes of depression are leading to treatments beyond common antidepressants such as Prozac and Zoloft, researchers are reporting in the in the journal Current Psychiatry.

Depression treatments on the horizon include new medications, electrical and magnetic stimulation of the brain and long-term cognitive behavioral therapy for stress management.

Authors are Murali Rao, MD, and Julie M. Alderson, DO. Rao is professor and chair of the Department of Psychiatry and Behavioral Neurosciences at Loyola University Chicago Stritch School of Medicine, and Alderson is a resident at East Liverpool City Hospital in East Liverpool, Ohio.

For more than 50 years, depression has been studied and understood as a deficiency of chemical messengers, called neurotransmitters, that carry signals between brain cells. Commonly used antidepressants are designed to either increase the release or block the degradation of three neurotransmitters dopamine, norepinephrine and serotonin.

But drugs that target neurotransmitters, such as Prozac, Zoloft and Paxil, succeed in inducing the remission of depression in fewer than half of patients. This has prompted researchers "to look beyond neurotransmitters for an understanding of depressive disorders," Rao and Alderson write.

New theories of depression are focusing on differences in neuron density in various regions of the brain; on the effect of stress on the birth and death of brain cells; on the alteration of feedback pathways in the brain and on the role of inflammation evoked by the stress response.

Chronic stress is believed to be the leading cause of depression, the authors write. Long-term stress harms cells in the brain and body. Stressful experiences are believed to be closely associated with the development of psychological alterations and, thus, neuropsychiatric disorders. In conditions of chronic stress exposure, nerve cells in the hippocampus begin to atrophy. (The hippocampus is a part of the brain involved with emotions, learning and memory formation.)

The new depression theories "should not be viewed as separate entities because they are highly interconnected," Rao and Alderson write. "Integrating them provides for a more expansive understanding of the pathophysiology of depression and biomarkers that are involved."

Such biomarkers are molecules in the body that can be indicators of depression. The authors identify more than a dozen potential biomarkers depression, including monoamine regulators; proinflammatory cytokines and other inflammatory mediators; mediators of glutaminergic activity and GABAergic activity; and regulators of neurogenesis.

Depression treatments currently offered or on the horizon include corticotropin-releasing hormone antagonists; dexamethasone; partial adrenalectomy; long-term cognitive behavioral therapy; ketamine and other NMDA antagonists; benzodiazepines; anesthetics; deep brain stimulation; transcranial magnetic stimulation; exogenous brain-derived neurotrophic factor; selective serotonin reuptake inhibitors; tricyclic antidepressants; atypical antidepressants; reduction in inflammation; and anti-inflammatory drugs.

It can take several months to recover from depression. Thus, Rao and Alderson write, current depression treatment programs that average six weeks "are not long enough for adequate recovery."


Contact: Jim Ritter
Loyola University Health System

Related medicine news :

1. Studies find new links between sleep duration and depression
2. USF psychologist: Childhood depression may increase risk of heart disease by teen years
3. Depression Free Method Review
4. How This Program Helps People Manage Their Stress and Anxiety Easily – HealthReviewCenter
5. Conquer Stress Forever Review – How To Reduce Stress, Anxiety and Depression Quickly Without Using Medication – Vinamy
6. Contractors who worked in conflict zones suffer high rates of PTSD, depression
7. How a concussion can lead to depression years later
8. Depression, Heart Disease a Two-way Street, from the December 2013 Harvard Heart Letter
9. Depression in pregnant mothers may alter the pattern of brain development in their babies
10. Vitamin D decreases pain in women with type 2 diabetes and depression
11. Upcoming Praeclarus Press Webinar Teaches How to Create a Comprehensive Safety Net for All Mothers Experiencing, or at Risk of Experiencing, Postpartum Depression
Post Your Comments:
(Date:6/26/2016)... ... ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center for ... Table in Battle Creek, MI, where the rehabilitation facility is located. This annual celebration ... world’s leading providers of cereal and other breakfast foods. Its residents often refer to ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: