Navigation Links
New depression treatments reported

MAYWOOD, IL New insights into the physiological causes of depression are leading to treatments beyond common antidepressants such as Prozac and Zoloft, researchers are reporting in the in the journal Current Psychiatry.

Depression treatments on the horizon include new medications, electrical and magnetic stimulation of the brain and long-term cognitive behavioral therapy for stress management.

Authors are Murali Rao, MD, and Julie M. Alderson, DO. Rao is professor and chair of the Department of Psychiatry and Behavioral Neurosciences at Loyola University Chicago Stritch School of Medicine, and Alderson is a resident at East Liverpool City Hospital in East Liverpool, Ohio.

For more than 50 years, depression has been studied and understood as a deficiency of chemical messengers, called neurotransmitters, that carry signals between brain cells. Commonly used antidepressants are designed to either increase the release or block the degradation of three neurotransmitters dopamine, norepinephrine and serotonin.

But drugs that target neurotransmitters, such as Prozac, Zoloft and Paxil, succeed in inducing the remission of depression in fewer than half of patients. This has prompted researchers "to look beyond neurotransmitters for an understanding of depressive disorders," Rao and Alderson write.

New theories of depression are focusing on differences in neuron density in various regions of the brain; on the effect of stress on the birth and death of brain cells; on the alteration of feedback pathways in the brain and on the role of inflammation evoked by the stress response.

Chronic stress is believed to be the leading cause of depression, the authors write. Long-term stress harms cells in the brain and body. Stressful experiences are believed to be closely associated with the development of psychological alterations and, thus, neuropsychiatric disorders. In conditions of chronic stress exposure, nerve cells in the hippocampus begin to atrophy. (The hippocampus is a part of the brain involved with emotions, learning and memory formation.)

The new depression theories "should not be viewed as separate entities because they are highly interconnected," Rao and Alderson write. "Integrating them provides for a more expansive understanding of the pathophysiology of depression and biomarkers that are involved."

Such biomarkers are molecules in the body that can be indicators of depression. The authors identify more than a dozen potential biomarkers depression, including monoamine regulators; proinflammatory cytokines and other inflammatory mediators; mediators of glutaminergic activity and GABAergic activity; and regulators of neurogenesis.

Depression treatments currently offered or on the horizon include corticotropin-releasing hormone antagonists; dexamethasone; partial adrenalectomy; long-term cognitive behavioral therapy; ketamine and other NMDA antagonists; benzodiazepines; anesthetics; deep brain stimulation; transcranial magnetic stimulation; exogenous brain-derived neurotrophic factor; selective serotonin reuptake inhibitors; tricyclic antidepressants; atypical antidepressants; reduction in inflammation; and anti-inflammatory drugs.

It can take several months to recover from depression. Thus, Rao and Alderson write, current depression treatment programs that average six weeks "are not long enough for adequate recovery."


Contact: Jim Ritter
Loyola University Health System

Related medicine news :

1. Studies find new links between sleep duration and depression
2. USF psychologist: Childhood depression may increase risk of heart disease by teen years
3. Depression Free Method Review
4. How This Program Helps People Manage Their Stress and Anxiety Easily – HealthReviewCenter
5. Conquer Stress Forever Review – How To Reduce Stress, Anxiety and Depression Quickly Without Using Medication – Vinamy
6. Contractors who worked in conflict zones suffer high rates of PTSD, depression
7. How a concussion can lead to depression years later
8. Depression, Heart Disease a Two-way Street, from the December 2013 Harvard Heart Letter
9. Depression in pregnant mothers may alter the pattern of brain development in their babies
10. Vitamin D decreases pain in women with type 2 diabetes and depression
11. Upcoming Praeclarus Press Webinar Teaches How to Create a Comprehensive Safety Net for All Mothers Experiencing, or at Risk of Experiencing, Postpartum Depression
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... ... of telemedicine programs in communities throughout Georgia, along with affiliate organizations, Alabama Partnership ... for their regional telehealth summits for Fall 2015. , Each of the ...
(Date:10/13/2015)... FL (PRWEB) , ... October 13, 2015 , ... ... the Driveway Snow Blanket, a snow melting invention that helps people in clearing snow ... billion and will continue to grow at 3.8% per year," says Scott Cooper, CEO ...
(Date:10/13/2015)... ... October 13, 2015 , ... Breathing ... people do not breathe correctly. According to T’ai Chi (also spelled “Taiji”) and ... to breathe correctly, in concert with the 7,000 year old tradition they teach, ...
(Date:10/13/2015)... ... October 13, 2015 , ... CVS/pharmacy, the retail division ... for enrolling and serving insurance consumers who do not have a bank account, ... monthly premiums. In “Health Plan Engagement Strategies: The ABCs of Serving Consumers Who ...
(Date:10/13/2015)... Baltimore, MD (PRWEB) , ... October 13, 2015 ... ... and retailing sustainable and eco-friendly home furnishings and décor, today announced it closed ... growth equity investor. The funds will be used to support the Company’s continued ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... ROSEMONT, Ill. , Oct. 12, 2015  To ... the American Academy of Orthopaedic Surgeons (AAOS) ... increase and improve physician, caregiver and patient education; the ... pain management; and support for more effective opioid abuse ... a member of the AAOS Patient Safety Committee. "The ...
(Date:10/12/2015)... 12, 2015 --> ... the global vital signs monitoring devices market in its upcoming ... and Opportunity Assessment 2015-2025." The global vital signs monitoring devices ... 9.5% and 9.2% in terms of value and volume, respectively, ... offers major insights in detail in this report. ...
(Date:10/12/2015)... Oct. 12, 2015   Royal Philips (NYSE: ... pathology, today announced a collaboration with Genomic Health ... provider of genomic-based diagnostic tests, to leverage Philips digital ... its molecular diagnostic testing processes.    ... of patient tissue samples and plays a crucial role ...
Breaking Medicine Technology: