Navigation Links
New depression treatments reported
Date:2/14/2014

MAYWOOD, IL New insights into the physiological causes of depression are leading to treatments beyond common antidepressants such as Prozac and Zoloft, researchers are reporting in the in the journal Current Psychiatry.

Depression treatments on the horizon include new medications, electrical and magnetic stimulation of the brain and long-term cognitive behavioral therapy for stress management.

Authors are Murali Rao, MD, and Julie M. Alderson, DO. Rao is professor and chair of the Department of Psychiatry and Behavioral Neurosciences at Loyola University Chicago Stritch School of Medicine, and Alderson is a resident at East Liverpool City Hospital in East Liverpool, Ohio.

For more than 50 years, depression has been studied and understood as a deficiency of chemical messengers, called neurotransmitters, that carry signals between brain cells. Commonly used antidepressants are designed to either increase the release or block the degradation of three neurotransmitters dopamine, norepinephrine and serotonin.

But drugs that target neurotransmitters, such as Prozac, Zoloft and Paxil, succeed in inducing the remission of depression in fewer than half of patients. This has prompted researchers "to look beyond neurotransmitters for an understanding of depressive disorders," Rao and Alderson write.

New theories of depression are focusing on differences in neuron density in various regions of the brain; on the effect of stress on the birth and death of brain cells; on the alteration of feedback pathways in the brain and on the role of inflammation evoked by the stress response.

Chronic stress is believed to be the leading cause of depression, the authors write. Long-term stress harms cells in the brain and body. Stressful experiences are believed to be closely associated with the development of psychological alterations and, thus, neuropsychiatric disorders. In conditions of chronic stress exposure, nerve cells in the hippocampus begin to atrophy. (The hippocampus is a part of the brain involved with emotions, learning and memory formation.)

The new depression theories "should not be viewed as separate entities because they are highly interconnected," Rao and Alderson write. "Integrating them provides for a more expansive understanding of the pathophysiology of depression and biomarkers that are involved."

Such biomarkers are molecules in the body that can be indicators of depression. The authors identify more than a dozen potential biomarkers depression, including monoamine regulators; proinflammatory cytokines and other inflammatory mediators; mediators of glutaminergic activity and GABAergic activity; and regulators of neurogenesis.

Depression treatments currently offered or on the horizon include corticotropin-releasing hormone antagonists; dexamethasone; partial adrenalectomy; long-term cognitive behavioral therapy; ketamine and other NMDA antagonists; benzodiazepines; anesthetics; deep brain stimulation; transcranial magnetic stimulation; exogenous brain-derived neurotrophic factor; selective serotonin reuptake inhibitors; tricyclic antidepressants; atypical antidepressants; reduction in inflammation; and anti-inflammatory drugs.

It can take several months to recover from depression. Thus, Rao and Alderson write, current depression treatment programs that average six weeks "are not long enough for adequate recovery."


'/>"/>

Contact: Jim Ritter
jritter@lumc.ede
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. Studies find new links between sleep duration and depression
2. USF psychologist: Childhood depression may increase risk of heart disease by teen years
3. Depression Free Method Review
4. How This Program Helps People Manage Their Stress and Anxiety Easily – HealthReviewCenter
5. Conquer Stress Forever Review – How To Reduce Stress, Anxiety and Depression Quickly Without Using Medication – Vinamy
6. Contractors who worked in conflict zones suffer high rates of PTSD, depression
7. How a concussion can lead to depression years later
8. Depression, Heart Disease a Two-way Street, from the December 2013 Harvard Heart Letter
9. Depression in pregnant mothers may alter the pattern of brain development in their babies
10. Vitamin D decreases pain in women with type 2 diabetes and depression
11. Upcoming Praeclarus Press Webinar Teaches How to Create a Comprehensive Safety Net for All Mothers Experiencing, or at Risk of Experiencing, Postpartum Depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... ... May 22, 2017 , ... An inventor from Columbia, S.C., wants to ... wife’s hand was damaged in a firework accident, so she couldn’t grip a pen ... problems." , He then designed and created a prototype for the HELPEN HAND, a ...
(Date:5/22/2017)... ... May 22, 2017 , ... Faithfully following pop culture, people today are forever ... and shaped through fitness programs. It carries on to skin nourished, pampered and nurtured ... irresistible, radiant smile. CDA has found that just like a perfectly cut ...
(Date:5/21/2017)... ... ... 52, was found dead on the night of Wednesday, May 17, 2017. It can be ... rock industry would take his own life, but the extremely talented and admired singer ... role in the death of Chris Cornell . , Depression and Drug Use , ...
(Date:5/21/2017)... ... May 20, 2017 , ... ... text designs created specifically for use in Final Cut Pro X. The business-oriented ... media productions. Pixel Film Studios’ ProParagraph Corporate will deliver a professional and distinguished ...
(Date:5/21/2017)... ... May 21, 2017 , ... Florida Pain Relief Group, ... of its newest location at 109 Silver Palm Ave., Melbourne, on Monday, May 22. ... With the opening of the Melbourne practice, PPOA operates 23 pain management clinics in ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)... , May 18, 2017  Two Bayer U.S. ... Association (HBA) during its recent 28 th ... City.  The event showcases HBA,s longstanding mission of furthering ... of healthcare. Cindy Powell-Steffen , senior ... U.S. Radiology division, and Libby Howe , a ...
(Date:5/15/2017)... ATLANTA , May 15, 2017  Amy Baxter ... the industry leader in noninvasive pain relief, was awarded ... MM&M magazine. Baxter was recognized at the MM&M ... New York City on May 10, ... helping the biopharma industry go "beyond the pill."  ...
(Date:5/12/2017)... May 12, 2017  The China and Canada ... that consumes less water, energy and detergent, and features a powerful ... LaughingU, a shoebox-sized washing machine that washes and sanitizes women,s panties ... ... is compact, and does not require an external water inlet. ...
Breaking Medicine Technology: