Navigation Links
New depression treatments reported
Date:2/14/2014

MAYWOOD, IL New insights into the physiological causes of depression are leading to treatments beyond common antidepressants such as Prozac and Zoloft, researchers are reporting in the in the journal Current Psychiatry.

Depression treatments on the horizon include new medications, electrical and magnetic stimulation of the brain and long-term cognitive behavioral therapy for stress management.

Authors are Murali Rao, MD, and Julie M. Alderson, DO. Rao is professor and chair of the Department of Psychiatry and Behavioral Neurosciences at Loyola University Chicago Stritch School of Medicine, and Alderson is a resident at East Liverpool City Hospital in East Liverpool, Ohio.

For more than 50 years, depression has been studied and understood as a deficiency of chemical messengers, called neurotransmitters, that carry signals between brain cells. Commonly used antidepressants are designed to either increase the release or block the degradation of three neurotransmitters dopamine, norepinephrine and serotonin.

But drugs that target neurotransmitters, such as Prozac, Zoloft and Paxil, succeed in inducing the remission of depression in fewer than half of patients. This has prompted researchers "to look beyond neurotransmitters for an understanding of depressive disorders," Rao and Alderson write.

New theories of depression are focusing on differences in neuron density in various regions of the brain; on the effect of stress on the birth and death of brain cells; on the alteration of feedback pathways in the brain and on the role of inflammation evoked by the stress response.

Chronic stress is believed to be the leading cause of depression, the authors write. Long-term stress harms cells in the brain and body. Stressful experiences are believed to be closely associated with the development of psychological alterations and, thus, neuropsychiatric disorders. In conditions of chronic stress exposure, nerve cells in the hippocampus begin to atrophy. (The hippocampus is a part of the brain involved with emotions, learning and memory formation.)

The new depression theories "should not be viewed as separate entities because they are highly interconnected," Rao and Alderson write. "Integrating them provides for a more expansive understanding of the pathophysiology of depression and biomarkers that are involved."

Such biomarkers are molecules in the body that can be indicators of depression. The authors identify more than a dozen potential biomarkers depression, including monoamine regulators; proinflammatory cytokines and other inflammatory mediators; mediators of glutaminergic activity and GABAergic activity; and regulators of neurogenesis.

Depression treatments currently offered or on the horizon include corticotropin-releasing hormone antagonists; dexamethasone; partial adrenalectomy; long-term cognitive behavioral therapy; ketamine and other NMDA antagonists; benzodiazepines; anesthetics; deep brain stimulation; transcranial magnetic stimulation; exogenous brain-derived neurotrophic factor; selective serotonin reuptake inhibitors; tricyclic antidepressants; atypical antidepressants; reduction in inflammation; and anti-inflammatory drugs.

It can take several months to recover from depression. Thus, Rao and Alderson write, current depression treatment programs that average six weeks "are not long enough for adequate recovery."


'/>"/>

Contact: Jim Ritter
jritter@lumc.ede
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. Studies find new links between sleep duration and depression
2. USF psychologist: Childhood depression may increase risk of heart disease by teen years
3. Depression Free Method Review
4. How This Program Helps People Manage Their Stress and Anxiety Easily – HealthReviewCenter
5. Conquer Stress Forever Review – How To Reduce Stress, Anxiety and Depression Quickly Without Using Medication – Vinamy
6. Contractors who worked in conflict zones suffer high rates of PTSD, depression
7. How a concussion can lead to depression years later
8. Depression, Heart Disease a Two-way Street, from the December 2013 Harvard Heart Letter
9. Depression in pregnant mothers may alter the pattern of brain development in their babies
10. Vitamin D decreases pain in women with type 2 diabetes and depression
11. Upcoming Praeclarus Press Webinar Teaches How to Create a Comprehensive Safety Net for All Mothers Experiencing, or at Risk of Experiencing, Postpartum Depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
(Date:6/24/2016)... ... , ... National recruitment firm Slone Partners is pleased to announce ... experience, as Vice President of North American Capital Sales at HTG Molecular . ... sales team in the commercialization of the HTG EdgeSeq system and associated reagents in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ANDOVER, Mass. and SAN CLEMENTE, Calif. ... California -based mobile pulmonary function testing company, is now ... portable PFT devices developed by ndd Medical Technologies , Inc. ... PFT testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ... CA , can get any needed testing done in the ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
Breaking Medicine Technology: