Navigation Links
New defense discovered against common hospital-acquired infection
Date:8/21/2011

GALVESTON Researchers have discovered a key mechanism used by intestinal cells to defend themselves against one of the world's most common hospital-acquired bacterial infections a mechanism they think they can exploit to produce a therapy to protect against the effects of the antibiotic-resistant bacteria.

The scientists made their discovery while investigating cellular responses to two powerful toxins generated by the bacteria Clostridium difficile, which can cause symptoms ranging from diarrhea to life-threatening bowel inflammation.

"About one percent of all hospital patients develop a C. difficile infection they're treated with antibiotics to the point that benign gut bacteria are knocked out, and because C. difficile is resistant to antibiotics it's able to proliferate," said University of Texas Medical Branch at Galveston associate professor Tor Savidge, lead author of a paper on the discovery to be published online Aug. 21 in Nature Medicine. "Then it releases these toxins that trigger colonic disease."

The toxins wreak havoc on cell structural proteins and biochemical communications networks, eventually killing the cell. But in order to do this damage, the toxins first have to get into the cell, and that means passing through the protective membrane that surrounds it.

It's there that Savidge and his collaborators a multidisciplinary team of researchers from UTMB, UCLA, Case Western Reserve University, Tufts University and the Commonwealth Medical College may have found a way to stop them.

On the molecular scale, C. difficile toxin proteins are quite large big enough that they have to "cleave" so that a smaller piece can slip through the membrane and into the cell. This cleavage is accomplished by a built-in molecular guillotine called a cysteine protease, which activates when the toxin encounters a molecule called InsP6 that is present at much higher levels inside the cell tha
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Malaria parasites camouflage themselves from the immune defenses of expectant mothers
2. A new line of defense against sexual assault
3. Cooling system may build eggs natural defenses against salmonella
4. Intestinal cell defense mechanism against bacteria
5. US Department of Defense supports study of brain, eye injuries in military personnel
6. Feinstein Institute to share $5M US Department of Defense grant
7. NIH funds advanced development of 3 biodefense vaccines
8. Mice with human bodys defenses
9. Key leukemia defense mechanism discovered by VCU Massey Cancer Center
10. BU School of Medicine researcher receives Department of Defense award
11. Scripps and Trius team up to develop new antibiotics with US Department of Defense grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... (PRWEB) August 20, 2014 Today, ... announced the publication of a new eBook, Affordable ... many small business owners feel uncertain about how ... family, and their bottom line. , The new ... and helps businesses navigate their upcoming health insurance ...
(Date:8/20/2014)... By Dennis Thompson ... -- U.S. teen birth rates fell dramatically during the past ... dollars, a new government report shows. An estimated 4 ... the decline, according to researchers from the U.S. Centers for ... "leapt out at me from the report," said Bill Albert, ...
(Date:8/20/2014)... study of chronic users of codeine-containing cough syrups ... brain white matter and associates these changes with ... used diffusuion tensor imaging (DTI) (an MR imaging ... white matter integrity of chronic CCS users. Deficits ... including the inferior fronto-occipital fasciculus, which other studies ...
(Date:8/20/2014)... WEDNESDAY, Aug. 20, 2014 (HealthDay News) -- Loss of ... help explain why many seniors have trouble falling and ... patients, sleep disruption can be especially severe and often ... researchers. The investigators analyzed data from the Rush ... who enrolled at age 65 and are being followed ...
(Date:8/20/2014)... 20, 2014 Park Cities Pet Sitter ... Presents 4 Pets supply donation drive that benefits the animal ... national campaign that coincides with the Humane Society of the ... 2nd through 8th, 2014. , As part of their participation, ... and monetary donations for the Presents 4 Pets drive from ...
Breaking Medicine News(10 mins):Health News:Teen Birth Rate Has Dropped Dramatically in Last Two Decades: CDC 2Health News:Teen Birth Rate Has Dropped Dramatically in Last Two Decades: CDC 3Health News:Seniors' Sleep Woes May Be Linked to Loss of Brain Cells 2Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 2Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 3Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 4
... blood vessels open to treat heart disease are poorly ... Journal of Interventional Cardiology . A case report ... the Detroit Medical Center Cardiovascular Institute, and her colleagues ... the recently marketed Ion stent (Boston Scientific, Natick, MA) ...
... from the University of Sheffield has found that people are willing ... year, for greener urban spaces. Researchers surveyed the public in ... out how much extra they were willing to pay in council ... They found that people were willing to pay more for greener ...
... Young athletes who routinely take hits to the head could ... a concussion, according to the results of a new preliminary ... (URMC) said their findings could be a red flag for ... young people whose brains are still developing. The study ...
... HealthDay Reporter , WEDNESDAY, Nov. 16 (HealthDay News) ... is better at controlling a serious kidney complication from ... suggests. People taking mycophenolate were about half as ... taking azathioprine (Imuran), according to the researchers. "This ...
... 132,000 Internal medicine physician and medical student members of ... (D-PA) for urging the Joint Select Committee on Deficit ... PHYSICIAN PAYMENT INNOVATION ACT. This proposal repeals the ... better payment systems for physicians providing services to patients ...
... is the recipient of one of Canada,s top awards ... the mammalian immune system, Kubes will accept the 2011 ... Canadian Institutes of Health Research (CIHR) at a ceremony ... Kubes for winning this prestigious award," said the Honourable ...
Cached Medicine News:Health News:Public willing to pay more for greener urban spaces 2Health News:Public willing to pay more for greener urban spaces 3Health News:Routine Head Hits in Sports May Injure Brain, Experts Warn 2Health News:Newer Drug Seems Better at Controlling Lupus Kidney Complication 2Health News:Newer Drug Seems Better at Controlling Lupus Kidney Complication 3Health News:Internists 'applaud' Schwartz Proposal to prevent 'devastating' Medicare cuts 2Health News:University of Calgary researcher named Canada's Health Researcher of the Year 2Health News:University of Calgary researcher named Canada's Health Researcher of the Year 3
(Date:8/20/2014)... 20, 2014 Research and Markets ... "Global Biosimilars/Follow-on-Biologics Market (Technology, Types, Applications, Services and ... report to their offering. A ... and geography) - Size, Share, Global Trends, Company ... and Forecast, 2013 - 2020", suggests that the ...
(Date:8/20/2014)... , August 20, 2014 ... report titled "Monochloroacetic Acid (MCA) Market for Cellulosics, Agrochemicals, ... Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 ... at USD 817.1 million in 2013 and is anticipated ... a CAGR of 3.6% during the forecast period from ...
(Date:8/20/2014)... -- Research and Markets has announced ... Care and Closure Market (Types, Applications, End User ... Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation ... their offering. The new report ... (types, applications, end user and geography) - Size, ...
Breaking Medicine Technology:Global Biosimilars/Follow-on-Biologics Market (Technology, Types, Applications, Services and Geography) - Research Report, 2013 - 2020 2Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 2Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 3Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 4Global Advanced Wound Care and Closure Market (Types, Applications, End User and Geography) - Forecast to 2020 2
... indicates that anti-inflammatory drugs may become a new tool ... leading global cause of death. In investigating a specific ... researchers used the Cardiochip, a gene analysis tool designed ... Center for Applied Genomics at The Children,s Hospital of ...
... March 14, 2012 OncoSec Medical Incorporated ... Medical System (OMS) ElectroOncology therapies to treat solid ... Institute in Santa Monica, CA, and Lakeland Comprehensive ... as enrolling sites, and investigators are screening patients ...
Cached Medicine Technology:Gene Chip, Invented by Children's Hospital of Philadelphia Scientist, Pinpoints New Target to Prevent Heart Disease 2Gene Chip, Invented by Children's Hospital of Philadelphia Scientist, Pinpoints New Target to Prevent Heart Disease 3OncoSec Initiates Two Additional Clinical Sites for Phase II Metastatic Melanoma Trial 2OncoSec Initiates Two Additional Clinical Sites for Phase II Metastatic Melanoma Trial 3OncoSec Initiates Two Additional Clinical Sites for Phase II Metastatic Melanoma Trial 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: