Navigation Links
New data obtained on liposomes employed in drug encapsulation and gene therapies
Date:2/8/2011

This release is available in Spanish.

University of Granada scientists and the Spanish Higher Institute for Scientific Research (CSIC) have made significant progress in understanding lipid membranes, which are extensively employed in the development of cosmetic and drug products, and which have potential application in the field of nanotechnology.

Phospholipid vesicles (liposomes) are colloidal systems that arise considerable interest from the pharmaceutical, cosmetic and food industry, since they are biocompatible in protein, nucleic acid, drug, etc encapsulation. Further, from a scientific perspective, liposomes are considered a model system of cell membranes that have been implemented in the study of biological transport processes through cell membranes, as well as in the study of aggregation processes induced by biological substances, etc.

To develop products of biotechnological interest, understanding thoroughly the electrostatic properties of these membranes is necessary. This was the purpose of Alberto Martn Molina and Csar Rodrguez Beas, from the Department of Applied Physics of the University of Granada, and Jordi Faraudo from the Instituto de Ciencias de Materiales in Barcelona (CSIC), authors of a study recently published in the journal Physical Review Letters (Vol. 104; pp 168103 (2010). 104, pp 168103 (2010)).

Inverting its Electrostatic Charge

This study discloses why certain lipid membranes can invert their surface electrostatic charge, that is, why these membranes have negative charge, but they can function as positive charge material in specific circumstances. This type of membranes are extensively employed in gene therapies.

Such behaviour is due to the fact that the interphase of these membranes in water is soft, permeable and highly hydrated. "Such environment attracts small objects with significant electric charge. These membranes tend to gather in large groups acquiring electric charge", researchers state. For the purpose of this study, electrophoresis experiments and computer-based simulations were conducted. Such trials were made using a supercomputer belonging to the Spanish Supercomputing Centre, since these trials required a long time and high calculation performance.

After a sustained period of several months, researchers obtained revealing results from simulations, which allowed them to prepare a new inversion mechanism for their experimental system. This mechanism is as follows: phospholipid membranes have the ability to absorb lanthanum cations, which go from being associated to the solution water molecules to associating to the membrane atoms.


'/>"/>

Contact: Alberto Martn Molina
almartin@ugr.es
34-958-240-025
University of Granada
Source:Eurekalert

Related medicine news :

1. New clue in leukemia mystery: Researchers identify poison employed by deadly enzyme mutations
2. Immigrants with disabilities more frequently employed than US-born persons with disabilities
3. CED Solutions Offers Free 3-Day Technical Windows 7 Certification Course for Unemployed Individuals
4. Generic drug may improve the effectiveness of cancer nanotherapies
5. New Therapies Offer Insight Into Battling Deadly Melanomas
6. Many U.S. Hospices Provide Alternative Therapies: Report
7. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
8. Many Brain Tumor Patients Turn to Alternative Therapies
9. John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers
10. New therapies and gene target advance the treatment and understanding of hard-to-treat leukemias
11. Alternative therapies may leave asthmatics gasping
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... June 24, 2017 , ... ... genetic testing for medications in select Florida and Texas doctors' offices and clinics. ... This new application of genetic testing recognizes the role genes play in determining ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode Island Quality Institute ... Alerts and Dashboards, an innovative new service enabling healthcare providers to proactively coordinate ... Alerts and Dashboards provide near real-time data about patients admitted to and/or discharged ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Military Officers Association of America ... secretary of Veterans Affairs, retired Marine Col. Thomas G. Bowman. , Bowman currently serves ... Bowman brings an intimacy with the issues and challenges veterans face with the VA. ...
(Date:6/23/2017)... CA (PRWEB) , ... June 23, 2017 , ... The ... facelift . Dr. Talei has come up with a proprietary technique that he ... and lifts tissues that have dropped. For all ages, patients can expect to look ...
(Date:6/23/2017)... ... , ... PureLife Dental is pleased to announce that California Dental Association (CDA) ... of the amalgam separator endorsement, all CDA members may purchase an ECO II amalgam ... value. This partnership between PureLife and CDA is especially timely as it coincides with ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... June 19, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), will ... webcast on Friday, July 28, 2017, beginning at 7:30 a.m. ... Only Dial-in information: To participate in the conference call, dial ... the call at least 10 minutes prior to the start ... Webcast: A simultaneous ...
(Date:6/16/2017)... , June 16, 2017 Datascope Corp. is voluntarily ... Datascope Corp. for a potential electrical test failure code.     ... PART NUMBER ... IABP CS300 IABP ... ...
(Date:6/14/2017)... 2017  ivWatch LLC, a medical device company focused ... therapy, is pleased to announce it was the Bronze ... Supplies and Equipment at the 2017 Medical Design Excellence ... industry. The award was presented by Medical Device and ... in New York during MD&M ...
Breaking Medicine Technology: