Navigation Links
New data obtained on liposomes employed in drug encapsulation and gene therapies
Date:2/8/2011

This release is available in Spanish.

University of Granada scientists and the Spanish Higher Institute for Scientific Research (CSIC) have made significant progress in understanding lipid membranes, which are extensively employed in the development of cosmetic and drug products, and which have potential application in the field of nanotechnology.

Phospholipid vesicles (liposomes) are colloidal systems that arise considerable interest from the pharmaceutical, cosmetic and food industry, since they are biocompatible in protein, nucleic acid, drug, etc encapsulation. Further, from a scientific perspective, liposomes are considered a model system of cell membranes that have been implemented in the study of biological transport processes through cell membranes, as well as in the study of aggregation processes induced by biological substances, etc.

To develop products of biotechnological interest, understanding thoroughly the electrostatic properties of these membranes is necessary. This was the purpose of Alberto Martn Molina and Csar Rodrguez Beas, from the Department of Applied Physics of the University of Granada, and Jordi Faraudo from the Instituto de Ciencias de Materiales in Barcelona (CSIC), authors of a study recently published in the journal Physical Review Letters (Vol. 104; pp 168103 (2010). 104, pp 168103 (2010)).

Inverting its Electrostatic Charge

This study discloses why certain lipid membranes can invert their surface electrostatic charge, that is, why these membranes have negative charge, but they can function as positive charge material in specific circumstances. This type of membranes are extensively employed in gene therapies.

Such behaviour is due to the fact that the interphase of these membranes in water is soft, permeable and highly hydrated. "Such environment attracts small objects with significant electric charge. These membranes tend to gather in large groups acquiring electric charge", researchers state. For the purpose of this study, electrophoresis experiments and computer-based simulations were conducted. Such trials were made using a supercomputer belonging to the Spanish Supercomputing Centre, since these trials required a long time and high calculation performance.

After a sustained period of several months, researchers obtained revealing results from simulations, which allowed them to prepare a new inversion mechanism for their experimental system. This mechanism is as follows: phospholipid membranes have the ability to absorb lanthanum cations, which go from being associated to the solution water molecules to associating to the membrane atoms.


'/>"/>

Contact: Alberto Martn Molina
almartin@ugr.es
34-958-240-025
University of Granada
Source:Eurekalert

Related medicine news :

1. New clue in leukemia mystery: Researchers identify poison employed by deadly enzyme mutations
2. Immigrants with disabilities more frequently employed than US-born persons with disabilities
3. CED Solutions Offers Free 3-Day Technical Windows 7 Certification Course for Unemployed Individuals
4. Generic drug may improve the effectiveness of cancer nanotherapies
5. New Therapies Offer Insight Into Battling Deadly Melanomas
6. Many U.S. Hospices Provide Alternative Therapies: Report
7. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
8. Many Brain Tumor Patients Turn to Alternative Therapies
9. John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers
10. New therapies and gene target advance the treatment and understanding of hard-to-treat leukemias
11. Alternative therapies may leave asthmatics gasping
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... a whole new perspective by using the title layers in ProSlice Levels to ... ProSlice Levels contains over 30 Different presets to choose from. FCPX users ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 Story Highlights: ... within the health care industry is causing providers to ... , Deloitte offers a suite of solutions for health ... efficient cost optimization: labor resource analysis, revenue cycle optimization ... better outcomes and better economics ...
(Date:6/24/2016)... Dublin - ... " Global Markets for Spectroscopy Equipment" report ... This report focuses on the global market of ... applications in various applications. The report deals with spectroscopy ... industries: pharmaceutical and biotechnology, food and beverage, and environmental ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology: