Navigation Links
New data obtained on liposomes employed in drug encapsulation and gene therapies
Date:2/8/2011

This release is available in Spanish.

University of Granada scientists and the Spanish Higher Institute for Scientific Research (CSIC) have made significant progress in understanding lipid membranes, which are extensively employed in the development of cosmetic and drug products, and which have potential application in the field of nanotechnology.

Phospholipid vesicles (liposomes) are colloidal systems that arise considerable interest from the pharmaceutical, cosmetic and food industry, since they are biocompatible in protein, nucleic acid, drug, etc encapsulation. Further, from a scientific perspective, liposomes are considered a model system of cell membranes that have been implemented in the study of biological transport processes through cell membranes, as well as in the study of aggregation processes induced by biological substances, etc.

To develop products of biotechnological interest, understanding thoroughly the electrostatic properties of these membranes is necessary. This was the purpose of Alberto Martn Molina and Csar Rodrguez Beas, from the Department of Applied Physics of the University of Granada, and Jordi Faraudo from the Instituto de Ciencias de Materiales in Barcelona (CSIC), authors of a study recently published in the journal Physical Review Letters (Vol. 104; pp 168103 (2010). 104, pp 168103 (2010)).

Inverting its Electrostatic Charge

This study discloses why certain lipid membranes can invert their surface electrostatic charge, that is, why these membranes have negative charge, but they can function as positive charge material in specific circumstances. This type of membranes are extensively employed in gene therapies.

Such behaviour is due to the fact that the interphase of these membranes in water is soft, permeable and highly hydrated. "Such environment attracts small objects with significant electric charge. These membranes tend to gather in large groups acquiring electric charge", researchers state. For the purpose of this study, electrophoresis experiments and computer-based simulations were conducted. Such trials were made using a supercomputer belonging to the Spanish Supercomputing Centre, since these trials required a long time and high calculation performance.

After a sustained period of several months, researchers obtained revealing results from simulations, which allowed them to prepare a new inversion mechanism for their experimental system. This mechanism is as follows: phospholipid membranes have the ability to absorb lanthanum cations, which go from being associated to the solution water molecules to associating to the membrane atoms.


'/>"/>

Contact: Alberto Martn Molina
almartin@ugr.es
34-958-240-025
University of Granada
Source:Eurekalert

Related medicine news :

1. New clue in leukemia mystery: Researchers identify poison employed by deadly enzyme mutations
2. Immigrants with disabilities more frequently employed than US-born persons with disabilities
3. CED Solutions Offers Free 3-Day Technical Windows 7 Certification Course for Unemployed Individuals
4. Generic drug may improve the effectiveness of cancer nanotherapies
5. New Therapies Offer Insight Into Battling Deadly Melanomas
6. Many U.S. Hospices Provide Alternative Therapies: Report
7. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
8. Many Brain Tumor Patients Turn to Alternative Therapies
9. John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers
10. New therapies and gene target advance the treatment and understanding of hard-to-treat leukemias
11. Alternative therapies may leave asthmatics gasping
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... ... Viewers who like to educate themselves on current issues and who enjoy ... societal issues tend to appreciate and love the "Informed" series, hosted by Rob Lowe. ... for causes around the world. , Running for charity has become a ...
(Date:3/24/2017)... ... March 24, 2017 , ... “Finding Christ ... #TruthwithGrace”: a devotional journal chronicling the writer’s path toward true communion with God. ... with God #TruthwithGrace” is the creation of published author Lea Michelle Johnson, a ...
(Date:3/24/2017)... , ... March 24, 2017 , ... “The Adventures of ... smart and silly dog who lives his life to the fullest, as God intended. ... published author Patti Holmgren, a mother and grandmother pursuing her passion for writing, especially ...
(Date:3/23/2017)... Alexandria, Virginia (PRWEB) , ... March 23, 2017 ... ... quality public health services to their communities, 16 more public health departments have ... This week’s decisions bring another 4.5 million people into the expanding network of ...
(Date:3/23/2017)... ... March 23, 2017 , ... The MBI “Hall of Fame” recognizes the contributions of those ... a significant impact on the careers of all others involved. , On Monday, ... into the MBI’s Hall of Fame. The induction took place during the World of ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... 2017  Zymo Research Corp., also known ... Inc., who designs, manufactures and distributes liquid ... teams Zymo Research,s DNA methylation detection and ... products with Hamilton,s high-throughput automation platforms. Zymo ... microbiomics and RNA isolation for use on ...
(Date:3/24/2017)... 24, 2017 ShangPharma, a leading ... cost-effective drug development and discovery services, technology, ... industry, announced today the intent for a ... be consolidating the Contract Research Organizations (CRO) ... ChemPartner. These entities include ChemPartner Shanghai, ChemPartner ...
(Date:3/24/2017)... A ReportsnReports.com report says, over the recent years, global ... sales of Adcetris and Kadcyla have been witnessing rapid growth after ... is driven by large number of ADC drugs in pipeline, rise ... ADCs. ... Tables and 94 Figures, 10 Major Company Profiles, spread across 154 ...
Breaking Medicine Technology: