Navigation Links
New data obtained on liposomes employed in drug encapsulation and gene therapies

This release is available in Spanish.

University of Granada scientists and the Spanish Higher Institute for Scientific Research (CSIC) have made significant progress in understanding lipid membranes, which are extensively employed in the development of cosmetic and drug products, and which have potential application in the field of nanotechnology.

Phospholipid vesicles (liposomes) are colloidal systems that arise considerable interest from the pharmaceutical, cosmetic and food industry, since they are biocompatible in protein, nucleic acid, drug, etc encapsulation. Further, from a scientific perspective, liposomes are considered a model system of cell membranes that have been implemented in the study of biological transport processes through cell membranes, as well as in the study of aggregation processes induced by biological substances, etc.

To develop products of biotechnological interest, understanding thoroughly the electrostatic properties of these membranes is necessary. This was the purpose of Alberto Martn Molina and Csar Rodrguez Beas, from the Department of Applied Physics of the University of Granada, and Jordi Faraudo from the Instituto de Ciencias de Materiales in Barcelona (CSIC), authors of a study recently published in the journal Physical Review Letters (Vol. 104; pp 168103 (2010). 104, pp 168103 (2010)).

Inverting its Electrostatic Charge

This study discloses why certain lipid membranes can invert their surface electrostatic charge, that is, why these membranes have negative charge, but they can function as positive charge material in specific circumstances. This type of membranes are extensively employed in gene therapies.

Such behaviour is due to the fact that the interphase of these membranes in water is soft, permeable and highly hydrated. "Such environment attracts small objects with significant electric charge. These membranes tend to gather in large groups acquiring electric charge", researchers state. For the purpose of this study, electrophoresis experiments and computer-based simulations were conducted. Such trials were made using a supercomputer belonging to the Spanish Supercomputing Centre, since these trials required a long time and high calculation performance.

After a sustained period of several months, researchers obtained revealing results from simulations, which allowed them to prepare a new inversion mechanism for their experimental system. This mechanism is as follows: phospholipid membranes have the ability to absorb lanthanum cations, which go from being associated to the solution water molecules to associating to the membrane atoms.


Contact: Alberto Martn Molina
University of Granada

Related medicine news :

1. New clue in leukemia mystery: Researchers identify poison employed by deadly enzyme mutations
2. Immigrants with disabilities more frequently employed than US-born persons with disabilities
3. CED Solutions Offers Free 3-Day Technical Windows 7 Certification Course for Unemployed Individuals
4. Generic drug may improve the effectiveness of cancer nanotherapies
5. New Therapies Offer Insight Into Battling Deadly Melanomas
6. Many U.S. Hospices Provide Alternative Therapies: Report
7. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
8. Many Brain Tumor Patients Turn to Alternative Therapies
9. John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers
10. New therapies and gene target advance the treatment and understanding of hard-to-treat leukemias
11. Alternative therapies may leave asthmatics gasping
Post Your Comments:
(Date:10/13/2015)... MA (PRWEB) , ... October 13, 2015 , ... Protein ... of the body, including muscle, bone, and blood. But how much protein does the ... complicated than it might seem, according to the October 2015 issue of Harvard ...
(Date:10/13/2015)... ... October 13, 2015 , ... T-System and Centegra ... than 59,000 emergency department visits per year, today announced the successful and rapid ... improve clinical, operational and financial outcomes. , In less than four ...
(Date:10/13/2015)... ... October 13, 2015 , ... World Patent Marketing , a vertically ... melting invention that helps people in clearing snow away from the streets and driveways. ... at 3.8% per year," says Scott Cooper, CEO and Creative Director of World Patent ...
(Date:10/13/2015)... ... October 13, 2015 , ... Thermi, ... the newest professional to introduce the latest development, ThermiVa® temperature controlled radiofrequency to ... leading professional in Obstetrics and Gynecology and a pioneer in the field of ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... and the Florida Apartment Association (FAA) has partnered with the Florida Department of ... the demand. , The FAA Smoke-Free Multifamily Housing Program launched last week ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE:  WX), a ... serving the pharmaceutical, biotechnology, and medical device industries, ... version of OncoWuXi, the first App in the ... and data on the go.  The OncoWuXi App ... to identify relevant tumor models for use in ...
(Date:10/13/2015)... Oct. 13, 2015  The Wyss Institute ... today announced the launch of its latest ... will introduce imaging reagents providing super-resolution capabilities ... of expensive specialized instruments. The announcement follows ... Office of Technology Development (OTD) and ...
(Date:10/13/2015)... -- --> --> Opportunities ... the Asthma and COPD Therapies market? Which areas are going ... new report shows you potential revenues to 2025, assessing data, ... 260 tables, charts, and graphs. Discover the most lucrative areas ... study lets you assess forecasted sales at overall world market ...
Breaking Medicine Technology: