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New data demonstrate potential for early detection of Alzheimer's disease
Date:6/16/2009

or of the study.

In this study, an NIR biospectroscopy analysis was conducted on blood plasma samples from a total of 63 subjects, 19 with Alzheimer's disease, 27 with mild cognitive impairment (a frequent indication of Alzheimer's disease) and 17 normal elderly controls, to measure the degree of oxidative stress in plasma. OS is caused by a chemical imbalance that can damage critical components of cells and biofluids, including proteins, lipids and DNA. OS is known to be involved in many neurological diseases, including Alzheimer's and Parkinson's disease.

In differentiating Alzheimer's disease patients from the normal elderly control group, NIR achieved a sensitivity of 80% and specificity of 77%. Fifteen and twelve patients with mild cognitive impairment were classified with the normal elderly control group and Alzheimer's disease groups, respectively.

"These results demonstrate the potential for NIR biospectroscopy to differentiate mild, and possibly pre-clinical, Alzheimer's disease from normal aging with high accuracy," Dr. Schipper added. "We are very encouraged by these data and look forward to testing this potential diagnostic tool in larger-scale studies."

"Near-Infrared Spectroscopy of Blood Plasma for Diagnosis of Sporadic Alzheimer Disease," was published in Journal of Alzheimer's Disease, 17:2 (June 2009).

Near-infrared spectroscopy is commonly used in medical diagnostics, food and agrochemical quality control, as well as combustion research.

This technology has been licensed to Molecular Biometrics, Inc., a metabolomics company specializing in the development of minimally-invasive biomarkers for Alzheimer's disease, Parkinson's disease and assisted reproduction.


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Contact: Gina Cella
ginacella@comcast.net
781-334-4692
IOS Press
Source:Eurekalert

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