Navigation Links
New data demonstrate potential for early detection of Alzheimer's disease
Date:6/16/2009

MONTREAL, CANADA, JUNE 16, 2009 Data published in the June issue of the Journal of Alzheimer's Disease demonstrated that minimally-invasive biospectroscopy was able to identify changes in oxidative stress (OS) levels in blood plasma, which may prove to be a useful biomarker in the early detection of Alzheimer's disease. There is currently no accepted laboratory test for diagnosing Alzheimer's disease.

Researchers at McGill University and the Lady Davis Institute for Medical Research (LDI) at the Jewish General Hospital (Montreal, Canada), have shown that near-infrared (NIR) biospectroscopy can identify a chemical signature, or biomarker, in blood that distinguishes Alzheimer's disease from normal aging and possibly other neurodegenerative conditions. Diagnosis of Alzheimer's disease is currently based solely on a patient's medical history and neurological examination, is labor-intensive and expensive, and often inconclusive in early stages of the illness. The availability of a biologic marker that reliably differentiates Alzheimer's disease from normal aging and other dementing conditions would represent a major achievement in the management of this common neurodegenerative disorder.

"There is an urgent need for an accurate diagnostic test to aid in the early diagnosis and management of Alzheimer's disease," said Hyman M. Schipper, MD, PhD, FRCPC, lead author of the study and Professor of Neurology and Medicine at McGill University. Dr. Schipper is also Founding Director of the Centre for Neurotranslational Research and a member of the Bloomfield Centre for Research in Aging at the LDI. "Our observations give us hope that biospectroscopy will offer a new approach to the early diagnosis of Alzheimer's disease and other neurodegenerative disorders." Dr. Schipper is a noted expert in brain aging and neurodegeneration. Dr. David Burns of the Department of Chemistry at McGill University, an experienced biospectroscopist, was a co-investigator of the study.

In this study, an NIR biospectroscopy analysis was conducted on blood plasma samples from a total of 63 subjects, 19 with Alzheimer's disease, 27 with mild cognitive impairment (a frequent indication of Alzheimer's disease) and 17 normal elderly controls, to measure the degree of oxidative stress in plasma. OS is caused by a chemical imbalance that can damage critical components of cells and biofluids, including proteins, lipids and DNA. OS is known to be involved in many neurological diseases, including Alzheimer's and Parkinson's disease.

In differentiating Alzheimer's disease patients from the normal elderly control group, NIR achieved a sensitivity of 80% and specificity of 77%. Fifteen and twelve patients with mild cognitive impairment were classified with the normal elderly control group and Alzheimer's disease groups, respectively.

"These results demonstrate the potential for NIR biospectroscopy to differentiate mild, and possibly pre-clinical, Alzheimer's disease from normal aging with high accuracy," Dr. Schipper added. "We are very encouraged by these data and look forward to testing this potential diagnostic tool in larger-scale studies."

"Near-Infrared Spectroscopy of Blood Plasma for Diagnosis of Sporadic Alzheimer Disease," was published in Journal of Alzheimer's Disease, 17:2 (June 2009).

Near-infrared spectroscopy is commonly used in medical diagnostics, food and agrochemical quality control, as well as combustion research.

This technology has been licensed to Molecular Biometrics, Inc., a metabolomics company specializing in the development of minimally-invasive biomarkers for Alzheimer's disease, Parkinson's disease and assisted reproduction.


'/>"/>

Contact: Gina Cella
ginacella@comcast.net
781-334-4692
IOS Press
Source:Eurekalert

Related medicine news :

1. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
2. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
3. Justice Department to Hold Media Event to Demonstrate New Database for Matching Unidentified Remains and Missing Persons Information
4. EHRVA Members Collaborate to Demonstrate Interoperability Success at NCHICA
5. Highmarks Hospital Pay-for-Performance Program Demonstrates Impressive Results
6. Facet Solutions AFRS(TM) Implant Demonstrates Positive Clinical Results After One Year Follow Up
7. STA Travel and Keep a Child Alive Ask College Students to Demonstrate Their Good Cents
8. LIALDA demonstrates prolonged release of mesalamine in an in vitro study using a simulated colon
9. ENDEAVOR IV achieves primary endpoint, demonstrates similar safety profile compared to Taxus stent
10. Real-World Studies of Carotid Artery Stenting Demonstrate Results Comparable to Guidelines for Patients Treated With Surgery
11. New Study Data Published in British Journal of Urology Demonstrates Cryoablation Effective for Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... Sherly Sulaiman, certified ... series of therapeutic sessions to help Los Angeles-area actors cope with rejection, improve ... The series, known as “Mindfulness for Actors and Artists,” has been featured in ...
(Date:2/10/2016)... ... February 10, 2016 , ... LaserShip, a regional parcel carrier that services ... of Eastern Michigan last Friday in order to aid in the Flint water crisis. ... include a facility located in Clio, only 15 miles away from Flint. , “We ...
(Date:2/10/2016)... California (PRWEB) , ... February 10, 2016 , ... ... are working together to expand dental health services to the developmentally disabled in ... We Care Dental’s operations to a new facility at 71-949 Highway 111, Suite ...
(Date:2/10/2016)... ... 10, 2016 , ... As part of its ongoing series of aquatic therapy ... webinar features a dynamic expert and thoughtful presentation to give attendees a better sense ... Both events are free to attend, but registration is required. , Rehabilitation ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... American Academy of Emergency Medicine , an emergency medicine professional association, ... practice management services . , The American Academy of Emergency Medicine, or AAEM, ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... YORK , Feb. 10, 2016 Immune ... biopharmaceutical company, announced today that it has filed a ... Leukemia and other cancers. --> ... treating cancer by administration of Ceplene (histamine dihydrochloride) in ... provides methods of predicting the efficacy of Ceplene and ...
(Date:2/10/2016)... , Feb. 10, 2016  The ALS Association, in partnership ... Grand Challenge to generate a biomarker to track TDP43 aggregation. ... up to a $1 million investment. ... disease that affects nerve cells in the brain and the ... initiate and control muscle movement, which often leads to total ...
(Date:2/10/2016)... 10, 2016 Convergence scenarios are ... various technologies that results in diverse solutions ... opportunities create a cyclical system where technology ... the development of new technologies. ... technology convergences, which are constantly fostering new ...
Breaking Medicine Technology: