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New data clarify relationship between diet and disease activity
Date:6/11/2014

respectively).

"We now have a much better understanding of the relationship between disease activity in patients with RA and the Mediterranean diet based on the findings from our 10-year-prospective cohort study TOMORROW," said lead author Mr. Yoshinari Matsumoto of the Department of Medical Nutrition, Graduate School of Human Life Science, Osaka City University, Japan.

A previous study had shown that, by adjusting to a Mediterranean diet, patients with RA could obtain a reduction in inflammatory activity, an increase in physical function, and improved vitality.4 However, this is the first time the key elements within a Mediterranean diet involved in these beneficial effects have been assessed.

"Confirming that daily intake of monounsaturated fatty acids, as a component of the Mediterranean diet, is an independent predictor of remission in patients with RA suggests that monounsaturated fatty acids might actually be suppressing disease activity," Mr. Matsumoto concluded.

In this study, data was collected from 208 consecutive patients with RA and 205 age- and gender-matched healthy volunteers. Daily food and nutrient intake status were assessed using a brief, self-administered diet history questionnaire and Mediterranean diet scores were calculated from reference results from the control group. Cholesterol influences disease activity in OA

To further investigate the link between cholesterol and OA pathology, ApoE deficient mice (a model for extremely high systemic LDL cholesterol levels) received a normal or cholesterol-rich diet for 54 days; wild type mice were used as controls. At day 18, experimental OA was induced by intra-articular injection of collagenase.2

While no differences between the two groups of mice fed a normal diet were found at the early time point of the study (day 28), by day 54 (end-point OA) the ApoE deficient mice showed a strong increase of ectopic bone formation, mainly at the medial coll
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Contact: EULAR Press Office
eularpressoffice@cohnwolfe.com
44-078-801-73209
European League Against Rheumatism
Source:Eurekalert

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