Navigation Links
New culprit discovered in T-cell acute lymphoblastic leukemia
Date:1/12/2012

A new study published in the journal Nature Medicine by NYU Cancer Institute researchers, shows how the cancer causing gene Notch, in combination with a mutated Polycomb Repressive Complex 2 (PRC2) protein complex, work together to cause T- cell acute lymphoblastic leukemia (T-ALL).

T-ALL is an aggressive blood cancer, predominately diagnosed in children. It occurs when one lymphoblast, an immature white blood cell, turns malignant, multiplying uncontrollably and spreading rapidly throughout the body. If left untreated, the disease can be fatal in a few weeks. Cancer-causing Notch mutations in T-ALL are well established, yet the detailed molecular mechanism mediating this Notch-induced cancer cell transformation was unknown until now.

"Our study presents new insight into how Notch acts in an antagonistic mode with PRC2 to promote T-ALL," said senior author, Iannis Aifantis, PhD, associate professor in the Department of Pathology and a member of the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center. "Moreover, our study shows frequent genetic inactivation on the genetic loci encoding for PRC2 components, inhibits its normal role as a gene expression regulator and further proves the tumor suppressor role of the complex in this disease."

The study shows a new dynamic interplay between Notch and PRC2 function. In the study, researchers analyzed Notch-driven epigenetic gene expression regulation changes in T-ALL. Findings show a clear loss of PRC2 function from the sites of Notch1 binding. In addition, researchers found recurrent gene mutations and deletions of the components of PRC2 in T-ALL patient samples. In the study, loss of PRC2 function fueled the Notch mutation. This provides evidence for a central role of deregulation of PRC2 in Notch-induced T-ALL.

"The inactivation of PRC2 complex due to Notch in T-ALL constitutes an important pathogenetic event in the formation of this
'/>"/>

Contact: Lauren Woods
lauren.woods@nyumc.org
212-404-3555
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers discover new culprit in atherosclerosis
2. Extra Calories, Low Protein Are Culprits in Weight Gain
3. Expert Panel Pinpoints Environmental Culprits in Breast Cancer
4. New culprit found in Lou Gehrigs disease
5. Researchers search for culprit behind dry eyes, mouths and more
6. Key culprit identified in breast cancer metastasis
7. Lung cancer culprit could offer target for therapy, UT Southwestern researchers report
8. Researchers identify breast cancer culprits
9. Gene discovered for Weaver syndrome
10. Dual-acting class of antimalarial compounds discovered by Novartis with potential to prevent and treat malaria
11. A better way to count molecules discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... (PRWEB) July 13, 2014 Chromatography ... biological components from various types of biological samples ... separate the sample mixture into two phase, namely ... the mobile phase run over the stationary phase, ... the components that provide the separation of mixture. ...
(Date:7/13/2014)... The North American water storage systems market is ... million by 2018, at a CAGR of 21.0%, from 2013 ... a rapid pace in North America. The U.S. is experiencing ... & wastewater storage and collection, and the increased spending on ... at a healthy rate in Canada, and is rising at ...
(Date:7/13/2014)... Advanced boilers are preferred over conventional boilers ... fuels, produce high-capacity power, emit fewer pollutants, and ... and climate change concerns, many countries have implemented ... and pollutants coming from fossilfuel-based power plants.North America ... boilers market., The global power rental market is ...
(Date:7/13/2014)... July 13, 2014 MarketsandMarkets recently ... [3D Modeling; 3D Scanning; 3D rendering; Layout and ... Analysis (2013 - 2018)”, which analyzes and studies ... North America, Western Europe, Eastern Europe, Middle East ... also draws the competitive landscape of the 3D ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 The Pearland, Texas ... ranging in age from four months to 12 years of ... karate classes to birthday parties and Summer Camps, is now ... Little Gym of Pearland after spending over six years ... roles, including Gym Director. , Berry has over ten ...
Breaking Medicine News(10 mins):Health News:North America Chromatography Systems Market Is Expected to Reach $6593.4 Million by 2018 - New Report by MicroMarket Monitor 2Health News:North America Chromatography Systems Market Is Expected to Reach $6593.4 Million by 2018 - New Report by MicroMarket Monitor 3Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 3Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 2Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 4Health News:The Little Gym of Pearland, TX Now Under New Ownership and Management 2
... and women,s health practitioner, has spoken out against the newest prescription ... bisphosphonates such as Boniva, Actonel, and Fosamax. , ... ... , noted medical researcher and women,s health practitioner, has spoken out ...
... A booster vaccination for parents of new babies and other ... the fatal form of whooping cough in young infants, say ... today. , Whooping cough (pertussis) is a distressing infectious ... and is usually given to infants at two to four ...
... has discovered how an experimental drug unleashes its destructive ... finding could help scientists develop ways to treat dormant ... against other bacteria as well. , A report ... Ph.D., of the National Institute of Allergy and Infectious ...
... announced it has filed,an additional law suit in Miami Dade ... (Genesis) f/n/a Genesis,Technology Group, Inc. (GTEC) and Genesis Equity Partners ... promissory note that became due in August 2008,and for Genesis ... due under,the note. , ...
... November 27 The Committee for Human,Medicinal ... recommending approval,for once-daily dosing of 800 mg ... combination therapy in treatment-naive adults (those who,have ... protease inhibitor, was,developed by Tibotec Pharmaceuticals, and ...
... a third of registered aged care nurses are considering ... says a new University of Melbourne study. , The ... at the University of Melbourne and the Australian Nursing ... sector are "emotionally exhausted" and not committed to their ...
Cached Medicine News:Health News:Susan Lark, MD Speaks Out Against the Newest Osteoporosis Drug, Reclast 2Health News:Susan Lark, MD Speaks Out Against the Newest Osteoporosis Drug, Reclast 3Health News:Susan Lark, MD Speaks Out Against the Newest Osteoporosis Drug, Reclast 4Health News:Parents of new babies should be considered for a whooping cough booster, say experts 2Health News:Experimental TB drug explodes bacteria from the inside out 2Health News:China West II Files Suit Against Genesis Pharmaceuticals and Capital Research Group Inc, Announces Conference Call Details 2Health News:European Committee for Human Medicinal Products (CHMP) Issues Positive Opinion for Once-Daily PREZISTA(R) (Darunavir) as Part of Combination Therapy for Treatment-Naive Adults With HIV-1 2Health News:European Committee for Human Medicinal Products (CHMP) Issues Positive Opinion for Once-Daily PREZISTA(R) (Darunavir) as Part of Combination Therapy for Treatment-Naive Adults With HIV-1 3Health News:European Committee for Human Medicinal Products (CHMP) Issues Positive Opinion for Once-Daily PREZISTA(R) (Darunavir) as Part of Combination Therapy for Treatment-Naive Adults With HIV-1 4Health News:Aged care workers to leave industry en masse due to stress, warns University of Melbourne study 2
(Date:7/11/2014)... July 11, 2014 According ... by Composition of Material, Application (Healthcare, Homeland security, ... Product (Personal Instrument, Hand-Held Instruments, Fixed, and Installed ... to 2013 - 2020", published by MarketsandMarkets, the Scintillator Market ... 5.62% from 2014 to 2020, and reach $479.16 ...
(Date:7/11/2014)... , July 11, 2014  Kindred Hospital Houston ... announce the opening of its new outpatient wound ... services to people with chronic, hard to heal ... can lead to amputation, lower leg wounds related ... delayed closure, and traumatic injury wounds which are ...
(Date:7/11/2014)... 2014 On Thursday, July ... the Dow Jones Industrial Average finished the day 0.42% lower ... 0.41%. The losses were broad based as eight out of ... Health Care Sector Index ended the day at 711.88, down ... one month. Investor-Edge has initiated coverage on the following equities: ...
Breaking Medicine Technology:Scintillator Market will be worth $479.16 Million by 2020 2Scintillator Market will be worth $479.16 Million by 2020 3Scintillator Market will be worth $479.16 Million by 2020 4Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4
... new Mayo,Clinic study found that regular physical exercise ... of the brain that affects nerve cells,involved in ... the,American Academy of Neurology Annual Meeting in Chicago ... impairment can function reasonably well,in everyday activities, but ...
... IND Filing for Novavax,s ... Seasonal Influenza Vaccine Candidate, ROCKVILLE, Md., April 16 ... has received positive results from an,immunogenicity study in ferrets inoculated ... enable Novavax to,complete its planned investigational new drug ("IND") application ...
Cached Medicine Technology:Mayo Clinic Finds Exercise Can Reduce the Risk of Mild Cognitive Impairment 2Novavax Reports Positive Results from Preclinical Studies of its VLP-based Trivalent Seasonal Influenza Vaccine Candidate 2Novavax Reports Positive Results from Preclinical Studies of its VLP-based Trivalent Seasonal Influenza Vaccine Candidate 3
... are offered as 1-piece or modular, in ... instruments may be customized with handles of ... insulation and flush ports. Many standard patterns ... may affect delivery times. , Please ...
... special order products are offered as 1-piece ... lengths. The modular instruments may be customized ... such as ratchets, insulation and flush ports. ... stock. Customer specifications may affect delivery times. ...
... Featured Products are kept ... and are offered as ... regular or extra long ... with insulation, flush ports, ...
... The Featured Products ... at Mediflex and are ... modular in regular or ... come equipped with insulation, ...
Medicine Products: