Navigation Links
New culprit discovered in T-cell acute lymphoblastic leukemia
Date:1/12/2012

A new study published in the journal Nature Medicine by NYU Cancer Institute researchers, shows how the cancer causing gene Notch, in combination with a mutated Polycomb Repressive Complex 2 (PRC2) protein complex, work together to cause T- cell acute lymphoblastic leukemia (T-ALL).

T-ALL is an aggressive blood cancer, predominately diagnosed in children. It occurs when one lymphoblast, an immature white blood cell, turns malignant, multiplying uncontrollably and spreading rapidly throughout the body. If left untreated, the disease can be fatal in a few weeks. Cancer-causing Notch mutations in T-ALL are well established, yet the detailed molecular mechanism mediating this Notch-induced cancer cell transformation was unknown until now.

"Our study presents new insight into how Notch acts in an antagonistic mode with PRC2 to promote T-ALL," said senior author, Iannis Aifantis, PhD, associate professor in the Department of Pathology and a member of the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center. "Moreover, our study shows frequent genetic inactivation on the genetic loci encoding for PRC2 components, inhibits its normal role as a gene expression regulator and further proves the tumor suppressor role of the complex in this disease."

The study shows a new dynamic interplay between Notch and PRC2 function. In the study, researchers analyzed Notch-driven epigenetic gene expression regulation changes in T-ALL. Findings show a clear loss of PRC2 function from the sites of Notch1 binding. In addition, researchers found recurrent gene mutations and deletions of the components of PRC2 in T-ALL patient samples. In the study, loss of PRC2 function fueled the Notch mutation. This provides evidence for a central role of deregulation of PRC2 in Notch-induced T-ALL.

"The inactivation of PRC2 complex due to Notch in T-ALL constitutes an important pathogenetic event in the formation of this
'/>"/>

Contact: Lauren Woods
lauren.woods@nyumc.org
212-404-3555
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers discover new culprit in atherosclerosis
2. Extra Calories, Low Protein Are Culprits in Weight Gain
3. Expert Panel Pinpoints Environmental Culprits in Breast Cancer
4. New culprit found in Lou Gehrigs disease
5. Researchers search for culprit behind dry eyes, mouths and more
6. Key culprit identified in breast cancer metastasis
7. Lung cancer culprit could offer target for therapy, UT Southwestern researchers report
8. Researchers identify breast cancer culprits
9. Gene discovered for Weaver syndrome
10. Dual-acting class of antimalarial compounds discovered by Novartis with potential to prevent and treat malaria
11. A better way to count molecules discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... DiaSorin has announced that their new webinar , ... guest speaker Dr. Gregory A. Plotnikoff, a physician and ... Integrative Medicine. Dr. Plotnikoff serves as an integrative medicine ... Healing and as Senior Consultant, Center for Health Care ... as a co-editor of the new journal Global Advances ...
(Date:8/27/2014)... August 28, 2014 National Resident ... in the Association for Medical Education in Europe (AMEE) ... Milan, Italy August 30 – September 3, 2014. ... the international medical education community, share the benefits of ... strengthen resident physician placement in countries throughout the world. ...
(Date:8/27/2014)... Delta, a reliable supplier of high quality ... D7R Dozers to its used bulldozer collection. ... that all these items are offered with deep discounts. ... Delta’s market share in the coming September. , ... offer; he has much confidence in the discounted Used ...
(Date:8/27/2014)... Philadelphia, PA. Inc. magazine ranked Holganix as ... an exclusive ranking of the nation’s fastest-growing privately held ... the most important segment of the economy - America’s ... as members of the Inc. 500 list include Dell, ... of world’s greatest companies have had their start on ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Reviewing the ... will now be easier for the public when using ... that are promoted in all 50 states in the ... , The different insurers that are generating the rates ... possible for adults to use the programmed system without ...
Breaking Medicine News(10 mins):Health News:DiaSorin Announces New Webinar in Their Annual Vitamin D Series 2Health News:DiaSorin Announces New Webinar in Their Annual Vitamin D Series 3Health News:National Resident Matching Program International (NRMPI) to Exhibit at the 2014 AMEE Conference 2Health News:Reliable Supplier Delta Adds New Items To Its Used Bulldozer Collection 2Health News:Inc Magazine Unveils 33rd Annual List of America's Fastest-Growing Private Companies - the Inc. 500 2Health News:Home Insurance Prices for All 50 States Now Supplied at Consumer Insurance Portal Online 2
... Pacific Dental Services (PDS(TM)) provided dentistry to the Community of ... Los Angeles , Over 250 employees, affiliated dentists and family members helped those ... in need , World Impact, Inc.(C) was a ... ...
... obesity epidemic in explaining the troubling trend , , TUESDAY, ... pronounced reduction in risk factors for heart disease is ... that the trend has flattened, starting at the beginning ... date back a fair amount of time, but now ...
... 11 The number of heart attack patients,admitted to ... smoking ban were implemented, according to a Henry Ford,Hospital ... hospital admissions from,1999-2006 in Michigan for what is known ... a smoking ban could lead to 3,340 fewer,admissions annually., ...
... Anthem Blue Cross and,Blue Shield in Maine is ranked ... according to the current (Nov. 17) issue of U.S. ... recognition as,one of the nation,s best health plans is ... member satisfaction and NCQA,accreditation., "We work hard to ...
... in Thermotherapy, ALAMEDA, Calif. and PITTSBURGH, Nov. ... today the introduction of ReBound, a new and,innovative ... and joint contractures using radio frequency (RF) diathermy. ... treatment systems,to the physical therapy and athletic training ...
... and prevention, new report finds , , TUESDAY, Nov. 11 ... of educational materials, and meager data collection are hindering ... driving in the United States and aggressively tackle the ... Foundation (NSF) released its findings Tuesday as part of ...
Cached Medicine News:Health News:Watts Powerhouse Church Receives a Facelift Through the Volunteers of Pacific Dental Services(R) 2Health News:Watts Powerhouse Church Receives a Facelift Through the Volunteers of Pacific Dental Services(R) 3Health News:After Decades, Decreases in Heart Risk Factors Level Off 2Health News:Study: Smoking Ban Would Help Reduce Heart Attack Admissions 2Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 2Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 3Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 4Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 5Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 6Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 7Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 8Health News:Anthem Blue Cross and Blue Shield in Maine Among Top Insurers on U.S. News & World Report/National Committee for Quality Assurance America's Best Health Plans List 9Health News:Game Ready(TM) and ReGear Life Sciences(TM) Bring Innovative New Heat Therapy to Market 2Health News:Game Ready(TM) and ReGear Life Sciences(TM) Bring Innovative New Heat Therapy to Market 3Health News:States Asleep at the Wheel in Fighting Drowsy Driving 2
(Date:8/27/2014)... Research and Markets  has announced the addition of ... report to their offering. The Global ... in-depth study on the current state of the global ... basic overview of the industry including definitions, classifications, applications ... is provided for the international markets including development trends, ...
(Date:8/27/2014)... Aug. 27, 2014 Decision Resources Group finds ... Memphis health system and hospital ... integration, with rivals Methodist Le Bonheur Healthcare and Baptist ... to coordinate patient care. In addition, a national contract ... most health plan enrollment in the Memphis ...
(Date:8/27/2014)... , August 27, 2014 ResearchMoz ... States  Laparoscopes Market Outlook to 2020. New report, ... market data on the United States Laparoscopes market ... dollars, volume (in units) and average prices (in US ... Laparoscopes and Flexible Tip Video Laparoscopes), Robotic Surgical Systems ...
Breaking Medicine Technology:Global Pulse Oximeter Industry Report 2014 2Memphis-area Health Systems Turn Attention to Clinical Integration 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 3United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 4United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 5
... Saturday, August 20, veterinary cardiologists are going to the ... Heart Health Tour will stop with a soundproof medical ... Dog Park. (Photo:   http://photos.prnewswire.com/prnh/20110815/CG52446 ) ... veterinarians will be available to answer questions for dog ...
... 2011 For the first time, the U.S. ... clarifying how benefit-risk determinations are made during premarket ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) Released today, the ... regulatory pathway for high-risk medical devices. The recommendations ...
Cached Medicine Technology:Free Dog Heart Health Screenings Available August 20 in Providence 2FDA Proposes Guidelines That Clarify Benefit-Risk Determinations for Medical Devices 2
For the quantitative determination of aspartate aminotransferase (AST) in human serum. The reagents are used in routine examination and monitoring of therapy and relapses....
Intended for the quantitative determination of aspartate aminotransferase activity in serum or plasma. Reaction: Kinetic. Wavelength: 340 nm. Linearity: 440 U/L at 30C. Liquid buffer and dry powder r...
The Midas II Stainer is an automated slide stainer designed for use in hematology and microbiology laboratories....
... 44 is an "assembly-line worker" for routine ... cytology laboratories. It automatically stains big quantities ... increased large number of reagent stations in ... a high throughput. Up to 12 baskets ...
Medicine Products: