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New crizotinib side-effect
Date:11/21/2013

ndreds and thousands of doctors out there to believe in what they might see in their clinics and report things, leveraging all that experience for the greater good. In the cases of altered measures of kidney function and lowered testosterone with crizotinib, once we notice these side-effects and get the word out, patients can be much more appropriately managed," Camidge says.

The study, conducted by Camidge along with other CU Cancer Center researchers including first author Evelyn Brosnan, MD who was a final year medical student mentored by Dr. Camidge at the time of the research evaluated 38 patients with stage IV ALK positive NSCLC. The team used a simple blood test called creatinine to assess patients' kidney function converting it by a formula into an estimated glomerular filtration rate (GFR) before, during and after crizotinib treatment.

Patients' mean GFR fell by 23.9 percent following the commencement of crizotinib, with the majority of the drop occurring during the first two weeks of treatment before the effects leveled out. Fortunately, in the 16 patients for whom post-crizotinib data were available, all rapidly recovered their estimated kidney function back to 84 percent of their original values or more once the drug was stopped. If a patient's baseline kidney function is good the change in kidney function induced by crizotinib may not shift the estimated GFR outside of the normal range. However, in their paper, Brosnan and colleagues describe an early case of a patient with pre-existing kidney damage whose creatinine-assessed kidney function reduced to a worringly low level with crizotinib, such that a clinical decision was made to discontinue the drug.

"In addition to these data adding to the literature on the side effects of crizotinib, this study was a strong example of the collaboration possible in the university setting and at a comprehensive cancer center," said Dr. Brosnan, now a resident physician in Dartmouth, NH.
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Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

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