Navigation Links
New crizotinib side-effect
Date:11/21/2013

A University of Colorado Cancer Center study published today in the journal Cancer shows that using crizotinib to treat ALK positive non-small cell lung cancer (NSCLC) appears to reduce kidney function when assessed by one of the most commonly used clinical methods. Whether this reflects a true effect of crizotinib on kidney function, or only on the accuracy of this particular method for assessing it is being studied. Though kidney function recovered in almost all cases after the crizotinib was stopped, as patients may be on crizotinib for months or even years researchers recommend additional tests of kidney function if they are worried about changes in the standard kidney function test or are concerned about using other drugs that interact with the kidneys concurrently with crizotinib.

"Crizotinib is such a powerfully effective drug for patients with ALK positive lung cancer that approval was fast-tracked by the FDA. This was wonderful: it got the drug into clinics quickly. But it also means that the dataset on side effects available to write the initial instruction booklet on the drug was pretty small at the time. Clinicians in the community starting to use this and other fast-tracked drugs may therefore be the ones tasked with noticing some side-effects for the first time," says Ross Camidge, MD, PhD, director of the thoracic oncology clinical program at the University of Colorado Cancer Center and the senior author of the study.

For another example of a side effect that was not in the original data presented to the FDA, in an earlier study Camidge and colleagues showed that testosterone is reduced by crizotinib in 84 percent of male patients taking the drug.

"These patterns may be right there in front of our eyes, but because they haven't been described before sometimes you can talk yourself out of being the one to discover something new. As anti-cancer drugs enter the pharmacy quicker and quicker, we have to empower the hu
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Not all lung cancer patients who could benefit from crizotinib are identified by FDA-approved test
2. Crizotinib reduces tumor size in patients with ALK positive lung cancer
3. Ganetespib shows potency against ALK-positive lung cancer and overcomes crizotinib resistance
4. Multicenter study confirms low testosterone in 84 percent of lung cancer patients taking crizotinib
5. Targeted investigational therapy potential to overcome crizotinib resistance in lung cancers
6. Lower risk of serious side-effects in trials of new targeted drugs
7. pH-sensitive liposomal cisplatin improves peritoneal carcinomatosis treatment without side-effects
8. Lancet Oncology: Long-term side-effects of targeted therapies in pediatric cancer patients
9. Pradaxa Lawsuit Lawyers at Wright & Schulte LLC Disturbed by New Study Finding that Pradaxa Users Face Significantly Higher Risk of Bleeding Side-Effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... Legislation passed today by the House ... to help prevent inappropriate prescriptions in Medicare Part ... the Integrity of Medicare Act (PIMA), introduced by ... (R-TX) and Ranking Member Jim McDermott (D-WA), recognizes ... epidemic and implement the right policies, said the ...
(Date:2/27/2015)... Dawn Greene Hospice, a 10-bed facility located on the 15th ... East Side, was officially dedicated and blessed at a ceremony ... Cardinal Dolan. , Thomas J. Fahey, Jr., MD, chairman of ... the ArchCare Board of Trustees, presided over the event with ... MMW, and Christina McInerney, president and CEO of The Jerome ...
(Date:2/27/2015)... February 27, 2015 Mediaplanet today announces ... Health,” a campaign that aims to bring blood health ... care conversation. The stories in this edition go beyond ... of clinical care, hard-hitting advocacy, research and technological strides ... According the American Cancer Society, approximately every 3 ...
(Date:2/27/2015)... Healthpointe is now performing arthroscopy ... or diseases affecting the elbow , wrist ... throughout Southern California, and are dedicated in providing ... related to the upper extremities. , Dr. ... board-certified and fully trained in treating an array ...
(Date:2/27/2015)... 27, 2015 Dr. Christopher Saunders, a ... Special at his Chadds Ford, Pa., location. The spring ... 2015, and will be priced at $3,950 with all ... implants, it will include more than $3,000 in MedSpa ... of free Dysport. , Space is very limited, so ...
Breaking Medicine News(10 mins):Health News:PCMA Statement on the ‘Protecting the Integrity of Medicare Act’ 2Health News:The Dawn Greene Hospice Is Officially Dedicated 2Health News:The Dawn Greene Hospice Is Officially Dedicated 3Health News:Know Your Blood: Raising Awareness through Mediaplanet’s “Blood Health” Campaign 2Health News:Healthpointe is Now Performing Arthroscopic Surgery Techniques for Elbow, Hand and Wrist Injuries and Diseases, such as certain Ganglion Cysts 2Health News:Dr. Christopher Saunders Announces Spring Breast Augmentation Special at $3,950 2Health News:Dr. Christopher Saunders Announces Spring Breast Augmentation Special at $3,950 3
... ... Single Sign On Manager to allow complete its Identity Management Suite. Software allows for ... , ... 24, 2010 -- With the release of Enterprise Single Sign On Manager (E-SSO-M), Tools4ever ...
... ... Branding & Website , ... Stafford, VA (PRWeb) February 23, 2010 -- FlexRN, a nurse staffing agency ... and the launch of its new website at www.flexRN.com . The efforts ...
... others , WEDNESDAY, Feb. 24 (HealthDay News) -- ... by the experience, an English study finds. , University ... 270 students, and found little difference between students of ... male students actually had higher productivity following their parents, ...
... ... Mexico from Honeymooners to Business travelers to Spring Break Vacations , ... (PRWEB) -- When in Mexico for spring break, family ... an unforeseen emergency. AssistCare Mexico , a concierge-style health and security service with operations ...
... ... ... , ... , ...
... UK ... magnesium products, including magnesium oil, magnesium gel, and magnesium bath flakes. ... San Ramon, CA ... www.GoodHealthNaturally.com as the exclusive UK distributor of its Ancient Minerals topical magnesium supplements, ...
Cached Medicine News:Health News:Enterprise SSO Manager From Tools4ever Revolutionizes Identity and Access Management 2Health News:Nurse Staffing Agency, FlexRN, Unveils New Corporate Branding & Website 2Health News:Just in Time for Spring Break 2010, AssistCard Mexico Launches Concierge-style Health and Security Services for Travelers to Mexico 2Health News:Just in Time for Spring Break 2010, AssistCard Mexico Launches Concierge-style Health and Security Services for Travelers to Mexico 3Health News:Just in Time for Spring Break 2010, AssistCard Mexico Launches Concierge-style Health and Security Services for Travelers to Mexico 4Health News:Northern Illinois Proton Center on the Verge of Major Medical Breakthrough 2Health News:Northern Illinois Proton Center on the Verge of Major Medical Breakthrough 3Health News:Northern Illinois Proton Center on the Verge of Major Medical Breakthrough 4Health News:Northern Illinois Proton Center on the Verge of Major Medical Breakthrough 5Health News:Northern Illinois Proton Center on the Verge of Major Medical Breakthrough 6Health News:Northern Illinois Proton Center on the Verge of Major Medical Breakthrough 7Health News:Northern Illinois Proton Center on the Verge of Major Medical Breakthrough 8Health News:Ancient Minerals Topical Magnesium Oil Now Available in the UK 2Health News:Ancient Minerals Topical Magnesium Oil Now Available in the UK 3
(Date:2/27/2015)... , Feb. 27, 2015  Bionik Laboratories Corp. (OTC:DWTPD), ... announced today that it acquired Bionik Laboratories, Inc., a ... completed the sale to qualified accredited investors of units ... gross proceeds of approximately $6.2 million. Shares of the ... the OTC Markets under the symbol "DWTPD" until FINRA,s ...
(Date:2/26/2015)... DALLAS , February 27, 2015 ... Review, H2 2014 market research report to its ... the Corneal Ulcers, therapeutic pipeline. The ... information on the therapeutic development for Corneal Ulcers. ... infections that includes bacterial infections, viral infections & ...
(Date:2/26/2015)... MOUNTAIN VIEW, Calif. , Feb. 26, 2015  IRIDEX ... will release its fourth quarter and full year 2014 financial ... 2015.   In conjunction with the release, the Company will ... 5:00 p.m. Eastern Time on Thursday, March 5, ... other business developments. Interested parties may access the ...
Breaking Medicine Technology:Bionik Laboratories Raises $6.2 Million 2Bionik Laboratories Raises $6.2 Million 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 2Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 4Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 5IRIDEX Announces Fourth Quarter and Full Year 2014 Conference Call and Release Date 2
... - Cobalis Corp.,(OTCBB:CLSC), a pharmaceutical development company ... from two Phase III clinical trials for ... moderately severe,seasonal allergic rhinitis, commonly known as ... levels in both placebo and,PreHistin-treated patient groups, ...
... cell lung cancer -, LOS ANGELES, July 09, ... positive Phase III clinical,data published in the July ... that low expression of the biomarker,Excision-Repair Cross-Complementing 1 ... cancer (NSCLC) predicts for,sensitivity to cisplatin-based chemotherapy. ERCC-1 ...
Cached Medicine Technology:Cobalis Reports Phase III Trial Results for PreHistin in Seasonal,Allergic Rhinitis 2Cobalis Reports Phase III Trial Results for PreHistin in Seasonal,Allergic Rhinitis 3Cobalis Reports Phase III Trial Results for PreHistin in Seasonal,Allergic Rhinitis 4Cobalis Reports Phase III Trial Results for PreHistin in Seasonal,Allergic Rhinitis 5Response Genetics Announces Publication of a Phase III Clinical,Trial Demonstrating That Low Levels of ERCC-1 Help to Predict,Likelihood of Response to Cisplatin-Based Therapy in Lung Cancer 2Response Genetics Announces Publication of a Phase III Clinical,Trial Demonstrating That Low Levels of ERCC-1 Help to Predict,Likelihood of Response to Cisplatin-Based Therapy in Lung Cancer 3Response Genetics Announces Publication of a Phase III Clinical,Trial Demonstrating That Low Levels of ERCC-1 Help to Predict,Likelihood of Response to Cisplatin-Based Therapy in Lung Cancer 4
Quick Release buckle apron is user friendly with large support straps crisscrossing the back allowing proper placement of the belt at your waist....
... Our unique velcro design ... for additional support and comfort. ... two velcro flaps aid in ... A comfortable fit is attained ...
This one of a kind design also provides full body protection. Split down each side, like a poncho, this apron is simple to put on and take off. Available with an orthopedic wide belt or buckle belt....
Gonad shields protect the reproductive organs. Available in male and female models. One size fits all....
Medicine Products: