Navigation Links
New criteria for measuring tumor size and progression will help ease workloads in clinical trials
Date:1/19/2009

, and in using the same measures and endpoints, the more reliably we are able to interpret the results from a variety of sources," she said.

Key changes in RECIST 1.1 that will simplify, optimise and standardise the assessment of tumour burden in clinical trials are as follows: A reduction in the number of lesions to be assessed for response from a maximum of ten to five, and from five to a maximum of two per organ; New guidance on making robust measurements of lymph node involvement; Confirmation of response is required for trials with objective response as a primary endpoint, but is no longer required for randomised studies, since the control arm of these studies provides appropriate means for interpreting results of the experimental arm; The definition of disease progression has been refined so that it not only includes a 20% increase in the size of the lesion, but also a 5 mm absolute increase as well, so that changes of just a few mms in very small tumours, which may be within the range of measurement error, are not unnecessarily described as disease progression; Guidance on imaging, including its use in the detection of new lesions and the interpretation of FDG-PET scan assessment.

Prof Eisenhauer stressed that the recommendations are evidence-based: "They are grounded in the literature and where such information didn't exist as was the case in some areas we set about generating the evidence to guide and support the changes. The EORTC Data Centre, under the leadership of Jan Bogaerts and Patrick Therasse (co-authors of RECIST 1.1), undertook to create a warehouse of data from clinical trials of solid tumours from both industry and cooperative groups. We were able to test the recommendations on these data to look at the impact of proposed changes and decide whether the evidence supported the change or not."

The database consisted of over 6500 patients with more than 18000 target lesions, and was used to investigate the imp
'/>"/>

Contact: Emma Mason (media enquiries only)
wordmason@mac.com
44-077-112-96986
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. New appropriate use criteria guide treatment of patients with heart blockage
2. Eligibility criteria contribute to racial disparities in hospice use
3. New Criteria Could Expand Number of Liver Transplant Candidates
4. How Patients Can Meet the Criteria for Insulin Pump Therapy
5. New Rhode Island Hospital study shows inadequate diagnostic criteria for eating disorders
6. Capital BlueCross CEO Says Meaningful Statewide Competition Must Be Key Criteria in Pennsylvanias Review of Proposed Highmark-IBC Merger
7. Landmark Articles Published by QualityMetric Scientists Report Improvements in Short Form Health Status Measures and Establish Criteria for Future Development
8. BMI criteria for obesity surgery should be lowered, UT Southwestern researchers suggest
9. Criteria Predict Womens 5-Year Risk for Fracture
10. New Test Criteria Spots Rheumatoid Arthritis Sooner
11. Health Care Leaders to Use New National Criteria for Patient-Centered Medical Home
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 The ... ) in the U.S. District Court, Southern District of West ... Bard, Inc. in that proceeding’s first bellwether trial. In an ... for a new trial after finding that C.R. Bard had ...
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne ... highest annual revenues in the past three years. Today, the ... dresses. , According to the sales manager of the company, ... them in 2015. This point can be reflected on the ...
(Date:1/22/2015)... 2015 As interest in the value of ... momentum worldwide, Rev. Eric J. Hall , president and ... (HCCN), will be the keynote speaker on January 27 at ... health system. , The conference, “Hope and Resilience: Innovative and ...
(Date:1/22/2015)... USA (PRWEB) January 22, 2015 State ... statewide data management system with support from GEOSYSTEMS, a ... The new solution will leverage Hexagon Geospatial’s ERDAS ... vector data as well as point clouds and documents. ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... provide relief for "tennis elbow" but needs to be ... article in CMAJ ( Canadian Medical Association ... The study, a randomized controlled trial of 48 patients, ... the Tehran University of Medical Sciences that serves patients ...
... HACKENSACK, N.J. (April 26, 2010, 4 p.m. EDT) Myelodysplastic syndromes ... are nearly five times more common in seniors than previously ... John Theurer Cancer Center at Hackensack University Medical Center. ... patients are at much higher risk for heart attack, diabetes ...
... to be good candidates upon death, study finds , ... developed a new tool that may help neurologists identify ... that could potentially boost organ donation rates. , Coma ... for organ donation when they die because their other ...
... high cholesterol or diabetes now widespread, CDC survey finds ... of all American adults have either high blood pressure, ... for heart disease, stroke and other cardiovascular problems, a ... the U.S. National Health and Nutrition Examination Survey (NHANES) ...
... - The American Society of Pediatric Otolaryngology (ASPO) will ... during the 2010 Combined Otolaryngology Spring Meetings (COSM) - ... Vegas, NV. During the ASPO meeting, hundreds ... sessions featuring expert panelists will be presented focusing on ...
... ... book on both sides of the Atlantic. This layman,s account of his interest and research ... self worth, regardless of historical, cultural or religious backgrounds, as it strives to touch all ... Washington, ...
Cached Medicine News:Health News:Botulinum injection provides relief of tennis elbow 2Health News:MDS, a blood cancer, strikes nearly 5 times more Americans than previously thought 2Health News:MDS, a blood cancer, strikes nearly 5 times more Americans than previously thought 3Health News:Test Spots Potential Organ Donors Among Coma Patients 2Health News:Nearly Half of U.S. Adults Have Heart Risk Factors 2Health News:Nearly Half of U.S. Adults Have Heart Risk Factors 3Health News:Scientific meeting will host new research in children's ear, nose and throat health 2Health News:Life Coach and Author Thomas Finn's Highly Anticipated Book, 'A Better Tomorrow- Affirmations and Visualizations the Keys to Success,' Debuts June 15 2
(Date:1/23/2015)... 2015  Now available for sale, The Armor1 Ankle Roll ... ankle sprains by cushioning the ankle from an inversion ... the outside of any shoe type and allows the ... offering protection against sprains. With customers in physical therapy, ...
(Date:1/23/2015)... Cord Blood America, Inc. ( www.cordblood-america.com ) (OTC Bulletin ... a Preliminary Proxy Statement, Schedule 14A, with the U.S. Securities ... update for shareholders detailing why a "YES" vote to increase ... Shareholders, As we reflect upon the 2014 fiscal ...
(Date:1/23/2015)... 2015  Mallinckrodt plc (NYSE: MNK ) announced ... share repurchase program. The open-ended authorization permits the company ... ordinary shares. "Funding additional initiatives and ... we continue to pursue a range of focused growth ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4
... Dyax Corp.,(Nasdaq:DYAX) announced today positive topline results ... its lead product,candidate DX-88 (ecallantide), for hereditary ... data is scheduled for Tuesday,April 17, 2007 ... discovered, recombinant, plasma kallikrein,inhibitor, is in clinical ...
... 2007 - In a late-breaker,presentation at the ... the Study of the Liver (EASL), researchers ... of the PROVE 1 clinical trial,which is ... with,the investigational hepatitis C protease inhibitor telaprevir ...
Cached Medicine Technology:DX-88 for Hereditary Angioedema Meets Primary and Secondary,Endpoints in Phase 3 Trial (EDEMA3) 2DX-88 for Hereditary Angioedema Meets Primary and Secondary,Endpoints in Phase 3 Trial (EDEMA3) 3DX-88 for Hereditary Angioedema Meets Primary and Secondary,Endpoints in Phase 3 Trial (EDEMA3) 4DX-88 for Hereditary Angioedema Meets Primary and Secondary,Endpoints in Phase 3 Trial (EDEMA3) 5Interim Results Presented at EASL from PROVE 1 Clinical Trial of,Investigational Drug Telaprevir in Patients with Genotype 1,Hepatitis C 2Interim Results Presented at EASL from PROVE 1 Clinical Trial of,Investigational Drug Telaprevir in Patients with Genotype 1,Hepatitis C 3Interim Results Presented at EASL from PROVE 1 Clinical Trial of,Investigational Drug Telaprevir in Patients with Genotype 1,Hepatitis C 4Interim Results Presented at EASL from PROVE 1 Clinical Trial of,Investigational Drug Telaprevir in Patients with Genotype 1,Hepatitis C 5Interim Results Presented at EASL from PROVE 1 Clinical Trial of,Investigational Drug Telaprevir in Patients with Genotype 1,Hepatitis C 6Interim Results Presented at EASL from PROVE 1 Clinical Trial of,Investigational Drug Telaprevir in Patients with Genotype 1,Hepatitis C 7Interim Results Presented at EASL from PROVE 1 Clinical Trial of,Investigational Drug Telaprevir in Patients with Genotype 1,Hepatitis C 8
Portex® Blue Line® cuffed endotracheal tubes come in a wide selection of sizes, each with a standard 15 mm ISO connector., ,Portex® Blue Line® endotracheal tubes are recognized world...
... Endotracheal Tube w. FlexiSlip™ Stylet, Murphy eye. Tube ... Rusch endotracheal tube with a preloaded Flexi-Slip Stylet ... storage space. The stylet has a low friction ... with a soft distal tip to reduce the ...
Cuffed pediatric endotracheal tubes, available from 2.5 mm to 4.5 mm inside diameter. Ruschelit® PVC. Magill tip - nasoral. X-ray opaque line. Graduated. Single use. Sterile...
... Ruschelit® PVC. Murphy eye-oral. High ... Graduated. Oral Cuffed Single use. For ... kinking of the tube by incorporating ... low-pressure cuff. Thermosensitive Ruschelit® PVC adapts ...
Medicine Products: