Navigation Links
New computer model may aid personalized cancer care
Date:1/23/2014

BOSTON Dana-Farber Cancer Institute scientists have developed a mathematical model to predict how a patient's tumor is likely to behave and which of several possible treatments is most likely to be effective.

Reporting in the journal Cell Reports, researchers combined several types of data from pre- and post-treatment biopsies of breast tumors to obtain a molecular picture of how the cancer evolved as a result of chemotherapy.

"Better understanding of tumor evolution is key to improving the design of cancer therapies and for truly individualized cancer treatment," said Kornelia Polyak, MD, PhD, a breast cancer researcher in the Susan F. Smith Center for Women's Cancers at Dana-Farber. The model was developed by Polyak and Franziska Michor, PhD, a computational biologist at Dana-Farber.

The study analyzed breast cancer samples from 47 patients who underwent pre-operative chemotherapy to shrink the tumor so it could be removed more easily. The biopsy samples, representing the major types of breast cancer, included specimens taken at diagnosis and again after the chemotherapy was completed.

As has been increasingly recognized, a tumor contains a varied mix of cancer cells and the mix is constantly changing. This is known as tumor heterogeneity. The cells may have different sets of genes turned on and off phenotypic heterogeneity or have different numbers of genes and chromosomes genetic heterogeneity. These characteristics, and the location of different types of cells with the tumor, shape how the cancer evolves and are a factor in the patient's outcome.

In generating their predictive model, Polyak and Michor integrated data on the genetic and other traits of large numbers of individual cells within the tumor sample along with maps of where the cells were located within the tumors.

"We asked two questions how heterogeneity influences treatment outcomes and how treatment changes heterogeneity," s
'/>"/>

Contact: Robbin Ray
robbin_ray@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Expert Project Manager Joins TERIS, a National Leader in eDiscovery, Information Governance, Computer Forensics and Relativity
2. Computer-controlled table could direct radiotherapy to tumours while sparing vital organs
3. Supercomputers help ORNL researchers identify key molecular switch that controls cell behavior
4. Computer model suggests genetic breast cancer screening may benefit those at intermediate risk
5. NSU’s Graduate School of Computer and Information Sciences to Offer Master of Science in Management Information Systems at Regional Campuses
6. HIV virus spread and evolution studied through computer modeling
7. NSU's Graduate School of Computer and Information Sciences to Host 2nd Annual ITPalooza
8. Forget Computers Releases Device Scout 3.0 for Robot Cloud — Manage All Apple Devices Smarter, Faster
9. SC&H Group Donates 84 Refurbished Laptop Computers to Children’s Guild and Arc Baltimore
10. Heated Mouse: Introducing ValueRays® Executive Series Heated Computer Mice
11. Apple IT Consulting Company, Forget Computers, the Developers of Robot Cloud, to Attend Upcoming MacTech Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (PRWEB) January 22, 2015 For over 20 years, ... Oceanside and Vista area has treated just about every ... personal injury circumstances. And for those same twenty-plus years, the ... of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... New York, NY (PRWEB) January 22, 2015 ... American College of Sports Medicine flagship journal Medicine ... supplementation with L-Citrulline before exercise may help reduce ... strenuous exercise. 1 , Participants in the ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative and ... to treat specific body parts and muscle groups. , ... to use patented cold therapy machine with the innovative IsoTube ... muscle injuries. IsoComforter has become the industry leader in ...
(Date:1/22/2015)... EBSCO Information Services (EBSCO) and the American ... effort to further promote visibility and adoption of the top ... AMA journals available via its subscription services, EBSCO will now ... , Long known as both a subscription agency and ...
(Date:1/22/2015)... Compare-autoinsurance.org has released a new blog post presenting ... auto insurance policy . , Some types of vehicles cannot ... the newly released blog post to see if their vehicle qualifies ... vehicles are some of the cars that cannot be covered by ...
Breaking Medicine News(10 mins):Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... further evidence to suggest that an enzyme secreted by the ... for new drugs to combat the deadly infectious disease. ... G (PknG), as a promising drug target back in 2004. ... is the secret weapon that enables the TB bug, Mycobacterium ...
... More bicycle riding and other lifestyle changes are urgently needed ... health and could also threaten the economy, the World Health ... indirectly to about 77,000 deaths per year in the region, ... is on the health of the people. If the trend ...
... have announced the birth of the first baby to be produced ... then frozen and defrosted for later use. ,The ... or who cannot be administered drugs that help egg maturation in ... around one year old, was born in Canada after work at ...
... advocates called Monday for tougher regulations on tobacco, as ... ways of boosting global efforts to stop smoking. ... Health Organisation (WHO) aims to find ways of harmonising ... advertising and protection from second-hand smoke. ,Hatai ...
... sleeping under insecticide-treated bed nets might protect older children ... transmission originates from adults and children over five years ... and are more attractive to mosquitoes. ,Current ... children and pregnant women in order to achieve over ...
... recognizing familiar smells could be experiencing an early sign of ... ,Scientists already know that the first lesions of the ... of the brain that is home to olfactory senses. ... tested 589 people aged between 54 to 90, and asked ...
Cached Medicine News:Health News:Structure of TB Enzyme Points the Way to New Drugs: Study 2Health News:UN Calls for Pedal Power to Reduce Environmental Damage 2Health News:First Baby Born from Eggs Matured and Frozen in the Lab 2Health News:Tougher Tobacco Rules Urged at Global Anti-smoking Talks 2
(Date:1/23/2015)... WASHINGTON , Jan. 23, 2015  A new analysis ... Part D 2015 enrollment data shows that 81 percent ... convenient access and extra discounts at certain pharmacies. The ... "Preferred pharmacy plans are now the foundation of ...
(Date:1/23/2015)... /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) is investigating potential ... ("Advaxis" or the "Company") (NASDAQ: ADXS ), ... to shareholders. On January 21, 2015, an ... Advaxis had misrepresented the clinical data for its ADXS-HPV ...
(Date:1/23/2015)... Jan. 23, 2015  Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT), announced ... trial of Lixte,s lead compound, LB‑100, is being conducted, has ... John S. Kovach , M.D., the founder and President of ... completed at a single site. Accrual of patients, however, was ...
Breaking Medicine Technology:New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3
... 3 CareFusion Corporation (NYSE: CFN ), a leading, ... the spinoff of Cardinal Health,s clinical and medical products businesses, ... host a conference call on Thurs., Nov. 5, 2009 at ... , The company is changing the date of its earnings ...
... (OTC Bulletin Board: CONX), a worldwide developer and marketer ... on Thursday, November 12, 2009, at 4:00 PM EST ... the first quarter ended September 30, 2009, and the ... , Corgenix invites all those interested in hearing management,s ...
Cached Medicine Technology:CareFusion Moves First Quarter Earnings Announcement to November 5 2
Excellent multi purpose agarose Nuclease-free, Gel point (1.5%): 36 1.5 C, EEO: 0.05-0.13 Gel strength (1%): > 1200 g/cm 2 ....
This agarose provides superior resolution of small PCR fragments and primers at lower concentrations than standard agaroses. A 3% gel clearly resolves a 10 bp ladder, and a 4% gel approaches the reso...
The PK TP System utilizes fixed chicken erythrocytes sensitized with components of the pathogenic T. pallidum (Nichols Strain) to perform a qualitative screening of Treponema pallidum in human serum ...
... donors on the PK7200 Automated Microplate System, ... attached to a gelatin particle for the ... of the CMV assay as compared to ... use of a gelatin particle as the ...
Medicine Products: