Navigation Links
New compounds may treat both alcohol and cigarette addictions
Date:11/3/2010

Researchers at the Ernest Gallo Clinic and Research Center at the University of California, San Francisco, and Pfizer Inc., have determined that two new compounds may be effective in treating both alcohol and nicotine dependence at the same time.

In a paper published in the November 3, 2010 issue of Neuropsychopharmacology, the researchers showed that alcohol consumption in rodents was significantly decreased by two compounds that target neuronal nicotinic acetylcholine receptor (nAChR) subtype 34*.

nAChRs are proteins found in the brain and broader central nervous system that mediate the effects of substances such as nicotine. Recent human genetic studies have shown that the genes encoding the 34* subtype are of significant importance for susceptibility to both alcohol and nicotine dependence.

"The problem has been translating these important genetic findings into more effective medications for people," said co-senior author Selena E. Bartlett, PhD, director of the Preclinical Development group at the Gallo Center. The lead author of the study is Susmita Chatterjee, PhD, of the Gallo Center.

The work was done in collaboration with scientists led by co-senior author Hans Rollema, PhD, in the Neuroscience Research Unit at Pfizer Inc.

One of the new compounds, CP-601932, has been shown in a clinical study to be safe in humans, notes Bartlett. She recommends a clinical study to evaluate the compound's efficacy and potential benefits in treating both alcohol and nicotine dependence.

The other compound is PF-4575180. Both were developed by Pfizer.

"Alcohol and nicotine addiction are often treated as separate disorders," Bartlett says, "despite the fact that 60 to 80 percent of heavy drinkers smoke tobacco. There are very few effective strategies for treating these disorders separately, let alone together. Our data suggest that by targeting specific nAChR subtype
'/>"/>

Contact: Jennifer O'Brien
jennifer.o'brien@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
2. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
3. Concentration, timing and interactions are key when it comes to dietary compounds
4. New pyrimidine compounds may lead to improved treatments for childhood brain cancer
5. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
6. Breast cancer survivors often rate post-treatment breast appearance only fair
7. Half of Teens Treated for Depression Will Relapse: Study
8. Peptide being tested to treat atherosclerosis inhibits ovarian cancer growth
9. Race may influence uterine cancer recurrence, despite treatment
10. Scientists seek urgent treatment for fatal sleeping sickness
11. Potential new treatment for deadly nipah and hendra viruses identified by Weill Cornell researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... 2015 Memphis, TN: MedixSafe has retracted ... a new security reader named Guardian 2. The ... a new biometric scanner that significantly increases the ... the new biometric scanner provides fast and easy ... MedixSafe narcotics lockers with Vanguard technology ...
(Date:2/28/2015)... Angeles, California (PRWEB) February 28, 2015 ... fully supported and showcased emerging brand at Houston ... held in Las Vegas sending its executive delegates ... Director of Business Development and Training Randolph Clarito. ... Association (IFA), was held last February 4-7 and ...
(Date:2/27/2015)... CA (PRWEB) February 27, 2015 ... Devices (IPD), has introduced miniature, wire bondable, silicon ESD ... Power LED markets. The ESD88NP and ... currents away from sensitive LED and IC products. ... Multilayer Varistors (MLV). All devices meet the requirements ...
(Date:2/27/2015)... 2015 Those who self-injure, ... misunderstood, misdiagnosed and therefore aren’t receiving effective ... Jacksonville-based addiction treatment center Lakeview Health ... acclaimed Lakeview Professional Lecture Series to counselors, ... this complicated condition. , “Self-injurious ...
(Date:2/27/2015)... Clinovo, a leading provider of cloud-based eClinical software, ... at the CALBIO2015 conference taking place in ... at Booth # 141. , ClinCapture ... builder allowing Clinical Trials Managers to create CRFs and ... programming experience. Clinovo’s new pricing model offers a free ...
Breaking Medicine News(10 mins):Health News:New Name Announced For Newest MedixSafe Readers – MedixSafe Vanguard 2Health News:1Heart Caregiver Services Showcases Emerging Brand at Franchise Expo South and IFA Annual Convention 2Health News:1Heart Caregiver Services Showcases Emerging Brand at Franchise Expo South and IFA Annual Convention 3Health News:OnChip Introduces New Series of Space Saving Bare-die Zener Diodes for Transient Voltage Suppression 2Health News:OnChip Introduces New Series of Space Saving Bare-die Zener Diodes for Transient Voltage Suppression 3Health News:Lakeview Health to Host Important Workshop Tackling the Rising Issue of ‘Cutters’ on March 27 2Health News:Clinovo to Demo Its Self-Service, Cloud-Based EDC Solution at CALBIO2015 on March 2nd and 3rd, 2015 2
... Germany has spawned a major scientific debate by claiming ... the atmosphere every year exacerbating the greenhouse effect. ... Planck Institute for Chemistry has reaffirmed findings by his ... had detected methane exhaled from living plants. ...
... unfairly not only makes your blood boil in anger, but as ... of having a heart attack. ,Researchers base their ... British government in London. ,As a part of the ... responses to the statement: "I often have the feeling that I ...
... the horizontally inclined. An American inventor has come out ... lose weight , while working at the computer. ... who designed the standup "walk-and-work" desk, suggest it could ... are traditionally sit-down tasks. The workstation can be locked ...
... States, anxiety appears to increase the risk of heart attacks and ... ,Coronary artery disease is caused by plaque build-up on the inside ... heart. This causes them to harden and narrow. ... and other serious complications. , According to a report ...
... from grains and cereals and of magnesium may each be ... to a report and meta-analysis in the issue of ... number of people diagnosed with diabetes worldwide may increase from ... to background information in the article. The associated illness, death ...
... In a recent survey, scientists have identified 216 compounds in ... ,The most inclusive survey till date of environmental chemicals linked ... are frequently experienced by most women. ,The extensive ... a long list of chemicals in our food, air and ...
Cached Medicine News:Health News:Scientists Saying Against Trees Sparks Debate 2Health News:Heart Attack Risk Increased by Unfair Treatment 2Health News:Stand Up And Get Back To Work! 2Health News:Dont Worry- Be Good To Your Heart 2Health News:Risk of Diabetes is Reduced by Intake of Grain Fiber and Magnesium 2Health News:List of Compounds That Causes Breast Cancer Identified 2
(Date:2/27/2015)... 2015  Pomerantz LLP is investigating claims on behalf ... "Company") (NASDAQ: VTAE ).  Such investors are ... rswilloughby@pomlaw.com or 888-476-6529, ext. 237. ... officers and/or directors have violated Sections 10(b) and 20(a) ... On February 27, 2015, the Company announced that ...
(Date:2/27/2015)... Securities lawyers at Dunnam & Dunnam ... (NASDAQ: SLXP ) in connection with a ... are encouraged to contact attorney Hamilton Lindley by ... upon the shareholder value of the transaction. Under terms ... $158.00 per share in cash. At least one analyst ...
(Date:2/27/2015)... , February 27, 2015 Report ... study showing you trends, R&D progress, and predicted revenues ... heading? What are the commercial prospects for this market ... potential revenues and other trends to 2025, discussing data, ... lets you assess regenerative medicine : cell-based therapies ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Vitae Pharmaceuticals, Inc. - VTAE 2Translational Regenerative Medicine: Market Prospects 2015-2025 2Translational Regenerative Medicine: Market Prospects 2015-2025 3Translational Regenerative Medicine: Market Prospects 2015-2025 4Translational Regenerative Medicine: Market Prospects 2015-2025 5Translational Regenerative Medicine: Market Prospects 2015-2025 6Translational Regenerative Medicine: Market Prospects 2015-2025 7Translational Regenerative Medicine: Market Prospects 2015-2025 8
... WarmAir® system from CSZ safely provides effective ... of the unique patented design of our ... lower velocity blower which supplies gently moving, ... that may spread contaminants to your patient ...
Since 1964, in its plants of Sesto Fiorentino, Sbisà produces a wide and qualified range of instruments for ophthalmology and optometry....
Inquire...
Inquire...
Medicine Products: