Navigation Links
New compounds may treat both alcohol and cigarette addictions
Date:11/3/2010

Researchers at the Ernest Gallo Clinic and Research Center at the University of California, San Francisco, and Pfizer Inc., have determined that two new compounds may be effective in treating both alcohol and nicotine dependence at the same time.

In a paper published in the November 3, 2010 issue of Neuropsychopharmacology, the researchers showed that alcohol consumption in rodents was significantly decreased by two compounds that target neuronal nicotinic acetylcholine receptor (nAChR) subtype 34*.

nAChRs are proteins found in the brain and broader central nervous system that mediate the effects of substances such as nicotine. Recent human genetic studies have shown that the genes encoding the 34* subtype are of significant importance for susceptibility to both alcohol and nicotine dependence.

"The problem has been translating these important genetic findings into more effective medications for people," said co-senior author Selena E. Bartlett, PhD, director of the Preclinical Development group at the Gallo Center. The lead author of the study is Susmita Chatterjee, PhD, of the Gallo Center.

The work was done in collaboration with scientists led by co-senior author Hans Rollema, PhD, in the Neuroscience Research Unit at Pfizer Inc.

One of the new compounds, CP-601932, has been shown in a clinical study to be safe in humans, notes Bartlett. She recommends a clinical study to evaluate the compound's efficacy and potential benefits in treating both alcohol and nicotine dependence.

The other compound is PF-4575180. Both were developed by Pfizer.

"Alcohol and nicotine addiction are often treated as separate disorders," Bartlett says, "despite the fact that 60 to 80 percent of heavy drinkers smoke tobacco. There are very few effective strategies for treating these disorders separately, let alone together. Our data suggest that by targeting specific nAChR subtypes, it may be possible to treat both alcohol and nicotine dependence with one medication."

Significantly, while the compounds had a significant effect on the rodents' alcohol consumption, their intake of sucrose was not affected. "This indicates that unlike currently approved alcohol abuse medications, the compounds do not interfere with the brain's natural reward system in a larger way," says Bartlett.


'/>"/>

Contact: Jennifer O'Brien
jennifer.o'brien@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Related medicine news :

1. Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
2. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
3. Concentration, timing and interactions are key when it comes to dietary compounds
4. New pyrimidine compounds may lead to improved treatments for childhood brain cancer
5. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
6. Breast cancer survivors often rate post-treatment breast appearance only fair
7. Half of Teens Treated for Depression Will Relapse: Study
8. Peptide being tested to treat atherosclerosis inhibits ovarian cancer growth
9. Race may influence uterine cancer recurrence, despite treatment
10. Scientists seek urgent treatment for fatal sleeping sickness
11. Potential new treatment for deadly nipah and hendra viruses identified by Weill Cornell researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... While it’s often important to ... Fortunately, an inventor from Austin, Texas, has identified a solution. , She developed a ... or restricted lighting. As such, it eliminates the need to turn on a light ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Lori R. ... a member of ElderCounsel, a national organization of elder law and special needs planning ... laws and rules. It also provides a forum to network with elder law attorneys ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... Fla. (PRWEB) , ... October 12, 2017 , ... IsoComforter, ... therapy products, announced today the introduction of an innovative new design of the shoulder ... pad so you get maximum comfort while controlling your pain while using cold therapy. ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... West Pharmaceutical Services, Inc. (NYSE: ... drug administration, today announced that it will release third-quarter ... October 26, 2017, and will follow with a conference ... 9:00 a.m. Eastern Time. To participate on the call, ... ID is 94093362. ...
(Date:10/11/2017)... Oct. 11, 2017  Caris Life Sciences ® , ... the promise of precision medicine, today announced that St. ... Precision Oncology Alliance™ (POA) as its 17 th ... St. Jude Crosson Cancer Institute will help develop standards ... of tumor profiling, making cancer treatment more precise and ...
(Date:10/11/2017)... 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... Las Piedras, Puerto Rico , where ... Following a comprehensive ... minor structural damage, temporary loss of power and minimal ... completed, manufacturing operations have resumed, and the company expects ...
Breaking Medicine Technology: