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New compound improves cognitive decline, symptoms of Alzheimer's disease in rodents
Date:1/12/2010

rules are categorized under the broad umbrella of cognition called "executive function" in humans. Examples of executive function such as planning, multitasking and activities of daily living, like cooking and getting dressed, are all capabilities that slip away as Alzheimer's disease progresses.

"In older people and in Alzheimer's disease patients, we call it flexible learning," Nicolle said. "They learn one rule, and they don't want to change the rule to get to the end goal."

Treatment with BQCA in mice allowed a previously learned rule to be replaced with a new one.

Because of the early indications that the compound could treat the behavioral symptoms associated with Alzheimer's, the researchers also believe BQCA could be targeted for treatment of schizophrenia. However, the compound will need further testing in the laboratory before it is ready for clinical trials with human participants.


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Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

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