Navigation Links
New combo of chemo and well-known malaria drug delivers double punch to tumors
Date:2/18/2012

Vancouver, British Columbia - Blocking autophagy -- the process of "self-eating" within cells -- is turning out to be a viable way to enhance the effectiveness of a wide variety of cancer treatments.

Specifically, blocking the action of an acidic inner cell part, which acts like a stomach and chews up proteins for recycling, is the main attack strategy, says Ravi K. Amaravadi, MD, an assistant professor of Medicine at the Perelman School of Medicine and Abramson Cancer Center at the University of Pennsylvania. Amaravadi will give a presentation on the role of autophagy in fighting cancer at the annual American Association for Advancement of Science meeting in Vancouver, British Columbia.

His lab and others have demonstrated that adding hydroxychloroquine (HCQ) an FDA-approved drug used commonly for malaria and rheumatoid arthritis -- to many cancer therapies, including chemotherapy, targeted therapy, radiation, and immunotherapy, can enhance the antitumor activity of these drugs in laboratory models of treatment-resistant cancers, and ongoing clinical trials.

Autophagy is increased in cancer cells. Normally, it is a survival pathway allowing a cell to recycle damaged proteins when it's under stress and reuse the damaged parts to fuel further growth.

Cancer cells might be addicted to autophagy, since this innate response may be a critical means by which the cells survive nutrient limitation and lack of oxygen commonly found within tumors. And, it is likely to explain how some cancer cells evade chemotherapies by using, essentially, a work around.

Nearly 30 phase I and Phase II clinical trials involving HCQ have been launched or are in planning stages in many different malignancies, including melanoma, multiple myeloma, renal cell carcinoma, colon cancer, prostate cancer, breast cancer, and others.

Preliminary results for most of the trials are encouraging. "Our assays performed on human blood and tissue samples indicate that high doses of HCQ are required to block autophagy in patients, and in some cases, such as in a brain tumor trial, these high doses, in combination with specific anticancer agents, can lead to toxicity for the tumor," says Amaravadi. "As the first phase I trials of HCQ are being completed, it is clear that in most cases the high-dose HCQ, in combination with existing cancer therapy, is well tolerated."

Randomized controlled trials using HCQ combinations to truly determine the effectiveness of the approach are planned. While these are being considered, the team will conduct additional laboratory experiments to identify more potent and specific inhibitors of autophagy and to identify biomarkers that can predict which patients are most likely to respond to this approach. To that end, the Amaravadi lab has identified a compound called Lys05, which is 10-fold more potent than HCQ at blocking the cell from giving the cancer cell a source of raw energy.

"While our knowledge of the role of autophagy in cancer is still in its infancy, the opportunity to learn about autophagy, both at the bench and the bedside, could accelerate the translation of basic advances in this field into clinical benefit for patients with cancer," says Amaravadi.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-459-0544
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. New Drug Combo for Hepatitis C Shows Promise
2. Two New Drug Combos May Fight Advanced Breast Cancers
3. Anti-estrogen combo better than single drug for hormone-sensitive breast cancer
4. Tender Breasts From Combo HRT Linked to Higher Cancer Risk
5. Combo hormone therapy has increased breast cancer risk over estrogen alone
6. New drug combo targets multiple cancers
7. Breast tenderness in women getting combo hormone therapy associated with increase in breast density
8. FDA Approves First Combo Drug for Diabetes, Cholesterol
9. Drug Combo Might Fight Aggressive Breast Cancer More Safely
10. For Some Prostate Cancer Patients, Combo Treatment Improves Survival
11. New Combo Therapy May Prevent TB, Save Lives in People With HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2017)... ... April 30, 2017 , ... TransLiquid Cartoon is a ... X. Editors can pick and choose from a variety of liquid transitions that ... shadows using simple color swabs. Utilize on-screen controls to fully manipulate transitions through ...
(Date:4/29/2017)... Aliso Viejo, CA (PRWEB) , ... April 29, 2017 , ... ... effects. Seamlessly transition from one video to the next without having to set ... bleeding, ripping, and blasting transitions to enhance your video production. , TransDark features dynamic ...
(Date:4/28/2017)... ... 2017 , ... An April 24th article on Yahoo! Beauty discusses the case of ... of a weight loss surgery. The woman, declaring “I will not hate my body anymore!” ... her dramatic weight loss. Dr. Feiz & Associates notes that, while it often refers its ...
(Date:4/28/2017)... ... April 28, 2017 , ... Beginning in 2017, Ridgecrest Herbals will ... begins with the popular ClearLungs Extra Strength formula. To ensure that the effectiveness of ... the following ways:, , Removal of the homeopathic element , ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... . These lamps offer an instant energy-saving solution for F32T8 fluorescent lamps on ... or disconnect ballasts. These 50,000 hour rated lamps utilize the existing electronic ballast, ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... Calif. , April 19, 2017  IRIDEX Corporation ... will release financial results for the first quarter 2017 ... 2017.  The Company,s management team will host a corresponding ... p.m. ET. Investors interested in listening to ... 707-0665 for domestic callers or (703) 326-3030 for international ...
(Date:4/19/2017)... 19, 2017 The Global Effective Microorganisms ... 2022 report has covered and analysed the potential of Global ... market size, shares and growth factors. The report identifies and ... opportunities in the global market. ... Browse 152 Tables and Figures, 6 Major Company Profiles, ...
(Date:4/19/2017)... April 19, 2017  Novartis today announced the ... Heart, Lung, and Blood Institute (NHLBI) of the ... of patients with treatment-naïve severe aplastic anemia (SAA) ... with eltrombopag at the initiation of and concurrently ... evaluated three sequential treatment groups, or cohorts. Cohort ...
Breaking Medicine Technology: