Navigation Links
New combo lung cancer therapy improves survival over single-line treatment
Date:12/15/2010

nhibitors such as erlotinib. In this study, the combination of erlotinib and the HDAC inhibitor entinostat lead to a small but not statistically significant improvement in survival in unselected patients but a large and statistically significant improvement in survival in patients with high expression of Ecadherin ( 9.4 months vs.5.4 months). While extremely promising, these results will need to be confirmed in a larger randomized phase III trial."

"Using a biomarker to select patients based on the tumor biology can improve patient outcomes versus treating an unselected patient population," said University of Colorado Cancer Center researcher Fred Hirsch, MD, PhD, professor of medical oncology at the CU medical school.

Data from the phase 2 trial, led by Robert Jotte, MD, PhD, of Denver's Rocky Mountain Cancer Center, was presented recently at the ASTRO 2010 Chicago Multidisciplinary Symposium in Thoracic Oncology, co-sponsored by the American Society for Radiation Oncology, the American Society of Clinical Oncology, the International Association for the Study of Lung Cancer and The University of Chicago.

"The data presented suggest that NSCLC patients with elevated E-cadherin levels can do better when treated with entinostat and erlotinib," said Joanna Horobin, MD, president and chief executive officer of Syndax, the company that holds worldwide rights to entinostat.

Syndax holds rights to the CU intellectual property related to this type of combination therapy which includes the use of E-cadherin to predict responsiveness to the therapy.

"Syndax has been a model commercial partner for the University, and we are both encouraged and excited by the Phase 2 results," said David Poticha, senior licensing manager at the CU Technology Transfer Office.


'/>"/>

Contact: Lindsay Lennox
lindsay.lennox@cu.edu
303-735-5518
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Exercise Combo Best for Type 2 Diabetes
2. Binge Drinking, Hypertension a Deadly Combo
3. Drug Combo Staves Off Type 2 Diabetes
4. Bone Marrow Cancer Patients May Benefit From Drug Combo
5. Short-Term Drug Combo May Help Prevent Colon Cancer
6. Novel therapy for metastatic kidney cancer developed at VCU Massey Cancer Center
7. Nanoscale gene ignition switch may help spot and treat cancer
8. Gene Research Sheds Light on Lung Cancer Survival Time
9. UNC scientists discover potential strategy to improve cancer vaccines
10. Breast inflammation is key to cancer growth, Kimmel Cancer Center researchers say
11. Gene information predicts survival time, possible new treatment options for lung-cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... 2014 Mirena lawsuits ( http://www.mirenalawsuit2014.com/ ... New Jersey’s Bergen County Superior Court, where the ... there is quickly approaching 1,300, Bernstein Liebhard LLP ... shows 1,293 lawsuits now pending in the consolidated ... complications resulting from spontaneous migration of the birth ...
(Date:11/28/2014)... Walder, one of South Florida’s top cosmetic dermatologists , ... that is designed to help her patients reduce unwanted fat ... has been praised by patients as being permanent, painless, and ... types of external fat reduction. , “If you can pinch ... According to Dr. Walder, Ultrashape works by targeting subcutaneous fat, ...
(Date:11/28/2014)... Texas (PRWEB) November 28, 2014 Dr. Paul Vitenas, ... will hold a Glitter & Glow Holiday Event for those in ... treatments offered at his practice. Glitter & Glow will take place ... Dr. Vitenas’ new location in the heart of Houston at 4208 ... of holidays and hope that you will come and celebrate the ...
(Date:11/28/2014)... 28, 2014 Secura Consultants, based ... insurance marketing organizations in the country focused on ... protection marketplace. Secura Consultants is proud to offer ... Financial Group, a leading global financial company. , ... With the ownership interest comes the need for ...
(Date:11/28/2014)... Celebration can quickly turn to tragedy if popular turkey ... Over the last decade, more than 141 serious fires ... turkey fryers, according to the U.S. Consumer Product Safety ... who tried to deep fry the turkey indoors, which ... Arthur Sanford, a burn surgeon at Loyola University Health ...
Breaking Medicine News(10 mins):Health News:Nearly 1,300 Mirena Lawsuits Now Filed in Consolidated New Jersey Litigation, Bernstein Liebhard LLP Reports 2Health News:Nearly 1,300 Mirena Lawsuits Now Filed in Consolidated New Jersey Litigation, Bernstein Liebhard LLP Reports 3Health News:Dr. Diane Walder Introduces New Fat Reduction Treatment Called Ultrashape 2Health News:Dr. Diane Walder Introduces New Fat Reduction Treatment Called Ultrashape 3Health News:Cosmetic Surgeon Dr. Paul Vitenas to Host Glitter & Glow Holiday Event 2Health News:Cosmetic Surgeon Dr. Paul Vitenas to Host Glitter & Glow Holiday Event 3Health News:Secura Consultants Offers Complimentary Buy-Sell Agreement Reviews 2Health News:Turkey Fryer Mishaps Can Cause Serious Burns 2
... MONDAY, May 23 (HealthDay News) -- Women who gained 18 or ... three times more likely to develop gestational diabetes during their second ... the study, published in the May 23 online issue of ... to shed six or more pounds between babies cut their risk ...
... primary care specialty of internal medicine has identified common clinical ... care and better use of finite clinical resources. ... activities appears online in the Archives of Internal Medicine ... list of best practices via consensus from actual practitioners, said ...
... 23 (HealthDay News) -- Researchers report that they,ve discovered a ... a finding that might provide insight into how the germ ... About 200 million people around the world are thought ... chronically infected people in the United States. Many don,t know ...
... , NEW YORK, May 23, 2011More than eight of ... believe states should be allowed to implement key provisions ... support, ahead of the timeline outlined in the law. ... more low-income families and creating insurance exchanges with premium ...
... , MONDAY, May 23 (HealthDay News) -- Undercover research ... to provide emergency care to children with private insurance ... Posing as mothers of a fictional 10-year-old boy ... 85 dental practices twice, four weeks apart, to determine ...
... is a reasonably safe and accurate method for the initial ... April issue of the Journal of the American College ... shave biopsies for not providing accurate T (tumor) stage information, ... to determine the impact of shave biopsies on the initial ...
Cached Medicine News:Health News:Losing Baby Weight Cuts Odds of Pregnancy-Linked Diabetes 2Health News:'Top 5' list helps primary care doctors make wiser clinical decisions 2Health News:'Top 5' list helps primary care doctors make wiser clinical decisions 3Health News:Researchers Find Cousin of Hepatitis C Virus in Dogs 2Health News:States should be allowed to implement key health reform law provisions early, experts say 2Health News:States should be allowed to implement key health reform law provisions early, experts say 3Health News:Some Dentists Reluctant to Treat Kids on Medicaid: Study 2Health News:Some Dentists Reluctant to Treat Kids on Medicaid: Study 3Health News:Shave biopsy is a safe and acceptable method for initial evaluation of melanoma 2
(Date:11/26/2014)... , November 26, 2014 A ... of the organ protrudes through the wall of a weak ... area at birth are some of the causes of hernias. ... hiatal, femoral, and incisional. An inguinal hernia is when part ... umbilical hernia is found in the area of the umbilicus. ...
(Date:11/26/2014)... , Nov. 26, 2014  Aridis Pharmaceuticals, ... produce novel therapies for infectious diseases, announced today ... an internationally recognized key opinion leader in the ... scientific advisory board. Founder and Chief ... "We believe Dr. Opal,s extensive experience investigating bacterial ...
(Date:11/26/2014)... 25, 2014 According to ... Power Source (Electric, Battery, Pneumatic), by Product (Drill, ... Cart), by Application (Orthopedic, ENT, Oral, Thoracic, Neurology) ... global Powered Surgical Instruments Market is estimated to ... 2014 and is expected to grow at a ...
Breaking Medicine Technology:Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 2Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 3Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 4Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4
... Arena Pharmaceuticals, Inc. (NASDAQ: ARNA ) announced ... the Citi 2012 Global Health Care Conference on Wednesday, February ... Time) at the Waldorf=Astoria in New York City. Jack Lief, ... a corporate overview. A live audio webcast of ...
... Switzerland, Feb. 23, 2012  Auxilium Pharmaceuticals, Inc. ... Pharmaceuticals Ltd. (SWX: ATLN.S) announced today that ... for the development, supply and commercialization of ... biologic for the potential treatment of Dupuytren,s ...
Cached Medicine Technology:Arena Pharmaceuticals to Present at the Citi 2012 Global Health Care Conference 2Arena Pharmaceuticals to Present at the Citi 2012 Global Health Care Conference 3Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 2Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 3Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 4Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 5Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 6
These are the Reusable Components (minus cannula), to be used with the VersaStep™ Plus Reposable Short System....
The VersaStep™ 5 mm and VersaStep™ PLUS Reposable system components for creating each access port are supplied in separate packages....
VersaStep™ Reposable Sterilization Trays....
... Instrument for applications in ... ,The VERSASTEP™ Plus instrument ... length is a unique ... radial dilation. It is ...
Medicine Products: