Navigation Links
New combo lung cancer therapy improves survival over single-line treatment
Date:12/15/2010

AURORA, Colo. (Dec. 14, 2010) A combination therapy for treating cancer discovered at the University of Colorado Cancer Center showed improved survival rates in patients with advanced non-small cell lung cancer (NSCLC), according to results from a double-blind, placebo-controlled phase 2 trial run by Syndax Pharmaceuticals.

The phase 2 results show that the combination of entinostat (Syndax's SNDX-275) and erlotinib was more effective in treating NSCLC in patients with elevated levels of the molecular cancer marker E-cadherin than using erlotinib alone. University of Colorado Cancer Center researchers, who are faculty at the University of Colorado School of Medicine, were the first to identify elevated E-cadherin as a targetable cancer marker, the first to develop the biomarker tumor testing process for elevated E-cadherin and the first to test the combined therapy.

About 40 percent of NSCLC patients have elevated E-cadherin levels, making this a significant advance towards highly personalized treatment for lung cancer patients. Entinostat controls expression of genes that can cause resistance to conventional cancer therapies like erlotinib.

"The outcome of patients with advanced lung cancer has been disappointing historically but the identification of new molecular features and new therapies directed at these molecular features has markedly improved outcome for some patients," said Paul Bunn, MD, professor of medical oncology at the CU medical school and principal investigator of the University of Colorado Cancer Center's Specialized Program of Research Excellence in Lung Cancer, funded by the National Cancer Institute.

"Unfortunately, some of the molecular changes are quite rare," said Bunn. "A more common molecular change is the high expression of epithelial markers such as Ecadherin. HDAC inhibitors such as entinostat can increase the expression of epithelial markers and can delay the development of resistance to EGFR i
'/>"/>

Contact: Lindsay Lennox
lindsay.lennox@cu.edu
303-735-5518
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Exercise Combo Best for Type 2 Diabetes
2. Binge Drinking, Hypertension a Deadly Combo
3. Drug Combo Staves Off Type 2 Diabetes
4. Bone Marrow Cancer Patients May Benefit From Drug Combo
5. Short-Term Drug Combo May Help Prevent Colon Cancer
6. Novel therapy for metastatic kidney cancer developed at VCU Massey Cancer Center
7. Nanoscale gene ignition switch may help spot and treat cancer
8. Gene Research Sheds Light on Lung Cancer Survival Time
9. UNC scientists discover potential strategy to improve cancer vaccines
10. Breast inflammation is key to cancer growth, Kimmel Cancer Center researchers say
11. Gene information predicts survival time, possible new treatment options for lung-cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... (PRWEB) July 27, 2014 1-Butene is ... has good solvent properties. 1–Butene can be manufactured either ... from the reaction of ethylene. Linear alpha olefin (alkene) ... to manufacture a number of important chemicals such as ... and so on. , The 1-Butene market is extremely ...
(Date:7/27/2014)... Metachromatic leukodystrophy (MLD, also called Arylsulfatase ... is commonly listed in the family of leukodystrophies ... affects the metabolism of sphingolipids. Leukodystrophies affect the ... which acts as an insulator around nerve fibers ... involves cerebroside sulfate accumulation. Metachromatic leukodystrophy, like most ...
(Date:7/27/2014)... -- Couples aren,t more likely to get divorced if ... research finds. The study only looks at trends ... a direct role in affecting whether couples stay together ... against fears that women,s growing educational advantage over men ... lead author of the study, said in an American ...
(Date:7/27/2014)... 2014 Ticket Down is a ... tickets in Miami, FL at the Sun Life Stadium ... is officially underway. In the opening game, Olympiacos from Superleague ... out to an early lead in their group. Six other ... this mini-tournament including Manchester City, Manchester United, AS Roma, Liverpool ...
(Date:7/27/2014)... (PRWEB) July 27, 2014 The ... a special promotion for fall meetings booked at the ... at this Downtown Denver hotel, just steps away from ... Denver’s central business district, and over 100 restaurants and ... their fall 2014 meetings at the HGI Denver will ...
Breaking Medicine News(10 mins):Health News:North America 1-Butene Market is Expected to Reach $794 million in 2018 - New Report by MicroMarket Monitor 2Health News:North America 1-Butene Market is Expected to Reach $794 million in 2018 - New Report by MicroMarket Monitor 3Health News:North America 1-Butene Market is Expected to Reach $794 million in 2018 - New Report by MicroMarket Monitor 4Health News:Metachromatic Leukodystrophy Therapeutics Clinical Trials Market Review H2 2014 Report Available at LifeScienceIndustryResearch.com 2Health News:Metachromatic Leukodystrophy Therapeutics Clinical Trials Market Review H2 2014 Report Available at LifeScienceIndustryResearch.com 3Health News:Metachromatic Leukodystrophy Therapeutics Clinical Trials Market Review H2 2014 Report Available at LifeScienceIndustryResearch.com 4Health News:Metachromatic Leukodystrophy Therapeutics Clinical Trials Market Review H2 2014 Report Available at LifeScienceIndustryResearch.com 5Health News:Wives' Higher Education May Not Affect Divorce Rate 2Health News:Guinness International Champions Cup Finals Tickets: Ticket Down Slashes Ticket Prices for International Champions Cup Finals in Miami at Sun Life Stadium 2Health News:Guinness International Champions Cup Finals Tickets: Ticket Down Slashes Ticket Prices for International Champions Cup Finals in Miami at Sun Life Stadium 3Health News:Stonebridge Companies’ Hilton Garden Inn Denver Downtown Announces Fall Meeting Promotion 2
... explain why C-section babies seem more likely to develop ... (HealthDay News) -- Babies who are born vaginally pick ... cesarean section, potentially affecting how their immune systems develop, ... provide more insight into why babies born through cesarean ...
... the polycystic ovary syndrome (PCOS), the most common hormone imbalance ... exposure to the chemical bisphenol A (BPA), found in many ... will be presented Sunday at The Endocrine Society,s 92nd Annual ... a known hormone disrupter, is elevated and associated with higher ...
... ... and revenues. In this Social Media Zuberance webinar we will show you how to avoid becoming ... ... (Founder and CEO of Zuberance) for a free interactive webinar at 11 AM PDT/2 ...
... fish that used to be feminized after chemicals, such as ... Treatment Plant and into Boulder Creek, are taking longer to ... process, according to a new study. The results will be ... San Diego. Although the levels of the chemicals that ...
... ... to Doctors, Physicians and Health Care Providers will monetize their time and streamline their patient ... the next sixty days. , ... (PRWEB) June 21, 2010 -- DocGreet.com is so sure that the services available to ...
... mental disorder affecting one in 100 people worldwide. Most cases ... and hallucinations as a teenager or adult. By that time, ... be difficult to treat. In a paper published recently ... at the University of North Carolina at Chapel Hill and ...
Cached Medicine News:Health News:Delivery Method May Determine the Bacteria Babies Acquire 2Health News:Delivery Method May Determine the Bacteria Babies Acquire 3Health News:Women with polycystic ovary syndrome have higher BPA blood levels 2Health News:Avoid Becoming Social Media Roadkill: Top 5 Ways to Combat Negative Word of Mouth (Free Webinar) 2Health News:Avoid Becoming Social Media Roadkill: Top 5 Ways to Combat Negative Word of Mouth (Free Webinar) 3Health News:Chemicals remaining after wastewater treatment change the gender of fish 2Health News:DocGreet Guarantees More Time and Money to Doctors and Health Care Providers 2Health News:Brain signs of schizophrenia found in babies 2
(Date:7/25/2014)...  CVS Caremark Corporation (NYSE: CVS ) ... 5, 2014, at 8:30 a.m. (EDT) with analysts and ... An audio webcast of the conference call ... of the CVS Caremark website for all interested parties.  ... webcast will be archived and available on the web ...
(Date:7/25/2014)... 25, 2014  Solanbridge Group Inc (OTC: SLNX) is ... interest in Buzznbrewz.com and the Letter of Intent issued ... fully executed Purchase Agreement. Charles R. ... proud to have Mr. David Pecoraro and ... in the private sector and developed a tremendous network ...
(Date:7/25/2014)... , July 25, 2014  AMETEK, Inc. (NYSE: ... Kurtis L. Goos as Vice President and General ... and Packaging (EMIP) Division. "I am pleased ... management and business development experience, especially in the medical ... contributions to the continued growth and success of our ...
Breaking Medicine Technology:Solanbridge Group Inc Announces Acquisition of Buzznbrewz.com 2AMETEK Names Kurtis L. Goos, Vice President & General Manager, Engineered Medical Components 2
... Actavis Group, the international generic pharmaceuticals company, ... US Food & Drug Administration to market Losartan Potassium ... 25 mg, 50 mg and 100 mg strength.  Losartan ... Iceland. Losartan Potassium Tablets, USP had US ...
... 12 WPI Holdings d/b/a Woodbury Health Products ("Woodbury"), ... announced today that it has completed the acquisition of ... Wilmington, North Carolina and founded in 1993, WMS is ... focused on urological catheters and sterile kits.  With a ...
Cached Medicine Technology:Actavis Receives Approval of Losartan Potassium Tablets, USP in the U.S. 2WPI Holdings Acquires Wilmington Medical Supply Inc. 2
The Precedent establishes a new generation of revision hip stems....
The Natural-Hip combines the surgical simplicity of a straight stem with many of the best features of an anatomic stem....
Calcar replacement stems provide options for revision and trochanteric fractures. Revision hip surgery and trauma often require prosthetic designs that replace proximal medial calcar bone loss....
... contributes to successful outcomes for your ... and technique, the materials you choose ... patients' outcomes, both short-term and long-term. ... Polyethylene. MARATHON Polyethylene is the first ...
Medicine Products: