Navigation Links
New combination effective against pancreatic cancer
Date:6/15/2010

The new cancer medication sorafenib looks promising. Sorafenib is used for advanced liver and kidney cancer and also appears to be effective against cancer stem cells in pancreatic cancer. The team led by Professor Dr. Ingrid Herr, Head of the Department of Molecular Oncosurgery, a group of the Department of Surgery at Heidelberg University Hospital, (Managing Director: Professor Dr. Markus W. Bchler) in cooperation with the German Cancer Research Center, tested the new substance in mice and pancreatic cancer cells. It inhibits resistant tumor stem cells and is also especially effective in combination with sulforaphane, an organic compound found in broccoli. The results has been published online in the prestigious medical journal "Cancer Research".

About 12,900 people in Germany develop pancreatic cancer every year. The disease is frequently noticed too late and very few people survive the diagnosis longer than one year. In particular, early precursor cells of the tumor known as cancer stem cells are responsible for uncontrollable growth of the cancer, metastasization to other organs, and recurrence shortly after surgery. They are extremely resistant to conventional therapy and are the focus of new treatment strategies.

Sorafenib is also effective for pancreatic cancer

In their tests on cancer cells and mice, the researchers showed that sorafenib inhibited typical properties of cancer stem cells from pancreas tumors and greatly reduced tumor growth. However, this effect lasted only for a short time and after four weeks, new colonies of cancer stem cells formed that no longer reacted to further treatment with sorafenib. "This resistance is probably related to a certain metabolic pathway, the NF-KB pathway, that is activated by sorafenib," explained Vanessa Rausch, a young researcher at the department of Surgery at Heidelberg University Hospital and first author of the article.

Broccoli reinforces the effect of sorafenib

There are naturally occurring substances that block precisely this undesired NF-KB pathway and thus make the dangerous cells vulnerable: vegetables from the cruciferous family such as broccoli and cauliflower possess a high content of sulforaphane, an anti-cancer compound. The experiments show that sulforaphane prevents the activation of the NF-KB pathway by sorafenib. The combination treatment reinforces the effect of sorafenib without causing additional side effects. The invasive potential of cancer cells was prevented metastasis was completely blocked in cell culture experiments. "We assume that nutrition may be a suited approach to break therapy resistance of cancer stem cells and thus make tumor treatment more effective," Professor Herr suggested.


'/>"/>

Contact: Dr. Ingrid Herr
i.herr@dkfz.de
062-215-637-123
University Hospital Heidelberg
Source:Eurekalert

Related medicine news :

1. Combination treatment regimen not effective against advanced melanoma
2. Combination therapy targets stubborn leukemia stem cells
3. Hair Loss Doctor Overcomes Odds To Produce First Ever Combination Topical Hair Growth Formula
4. Combination antibiotics effective against chlamydia-induced arthritis
5. Leeza Gibbons and ZERONA Equals a Winning Combination
6. Researchers find new chemotherapy combination shows promise in endometrial cancer
7. Combination Treatment May Help Depressed Alcoholics
8. Combination therapy more effective for enlarged prostate
9. WHI data confirm short-term heart disease risks of combination menopausal hormone therapy
10. Free Webinar Series at Aqualipo.com Shows How New Combination Liposuction/Fat Transfer Treatment Helps Patients Slim Down and Reduce Facial Wrinkling
11. New Drugs, New Combinations Fight Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
Breaking Medicine Technology: