Navigation Links
New combination effective against pancreatic cancer
Date:6/15/2010

The new cancer medication sorafenib looks promising. Sorafenib is used for advanced liver and kidney cancer and also appears to be effective against cancer stem cells in pancreatic cancer. The team led by Professor Dr. Ingrid Herr, Head of the Department of Molecular Oncosurgery, a group of the Department of Surgery at Heidelberg University Hospital, (Managing Director: Professor Dr. Markus W. Bchler) in cooperation with the German Cancer Research Center, tested the new substance in mice and pancreatic cancer cells. It inhibits resistant tumor stem cells and is also especially effective in combination with sulforaphane, an organic compound found in broccoli. The results has been published online in the prestigious medical journal "Cancer Research".

About 12,900 people in Germany develop pancreatic cancer every year. The disease is frequently noticed too late and very few people survive the diagnosis longer than one year. In particular, early precursor cells of the tumor known as cancer stem cells are responsible for uncontrollable growth of the cancer, metastasization to other organs, and recurrence shortly after surgery. They are extremely resistant to conventional therapy and are the focus of new treatment strategies.

Sorafenib is also effective for pancreatic cancer

In their tests on cancer cells and mice, the researchers showed that sorafenib inhibited typical properties of cancer stem cells from pancreas tumors and greatly reduced tumor growth. However, this effect lasted only for a short time and after four weeks, new colonies of cancer stem cells formed that no longer reacted to further treatment with sorafenib. "This resistance is probably related to a certain metabolic pathway, the NF-KB pathway, that is activated by sorafenib," explained Vanessa Rausch, a young researcher at the department of Surgery at Heidelberg University Hospital and first author of the article.

Broccoli reinforces the effect of sorafenib

There are naturally occurring substances that block precisely this undesired NF-KB pathway and thus make the dangerous cells vulnerable: vegetables from the cruciferous family such as broccoli and cauliflower possess a high content of sulforaphane, an anti-cancer compound. The experiments show that sulforaphane prevents the activation of the NF-KB pathway by sorafenib. The combination treatment reinforces the effect of sorafenib without causing additional side effects. The invasive potential of cancer cells was prevented metastasis was completely blocked in cell culture experiments. "We assume that nutrition may be a suited approach to break therapy resistance of cancer stem cells and thus make tumor treatment more effective," Professor Herr suggested.


'/>"/>

Contact: Dr. Ingrid Herr
i.herr@dkfz.de
062-215-637-123
University Hospital Heidelberg
Source:Eurekalert

Related medicine news :

1. Combination treatment regimen not effective against advanced melanoma
2. Combination therapy targets stubborn leukemia stem cells
3. Hair Loss Doctor Overcomes Odds To Produce First Ever Combination Topical Hair Growth Formula
4. Combination antibiotics effective against chlamydia-induced arthritis
5. Leeza Gibbons and ZERONA Equals a Winning Combination
6. Researchers find new chemotherapy combination shows promise in endometrial cancer
7. Combination Treatment May Help Depressed Alcoholics
8. Combination therapy more effective for enlarged prostate
9. WHI data confirm short-term heart disease risks of combination menopausal hormone therapy
10. Free Webinar Series at Aqualipo.com Shows How New Combination Liposuction/Fat Transfer Treatment Helps Patients Slim Down and Reduce Facial Wrinkling
11. New Drugs, New Combinations Fight Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now ... of Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Final Cut Pro X users can now reveal the media of their split ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution ... the emergency ambulance transport experience for the millions of people who require these ... disrupted the taxi industry through the use of technology. Now, SmartEMS has put ...
(Date:6/26/2016)... ... 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment ... Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This ... of the world’s leading providers of cereal and other breakfast foods. Its residents often ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is ... a fitness app. The fitness app plans to fix the two major problems leading the ... one size fits all type program , They don’t eliminate all the reasons ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
Breaking Medicine Technology: