Navigation Links
New clues uncover how 'starvation hormone' works, investigators at UT Southwestern report
Date:12/27/2010

DALLAS Dec. 26, 2010 New findings by UT Southwestern Medical Center researchers may solve a 17-year-old mystery about how the so-called "starvation hormone" affects multiple biological systems, including preventing insulin sensitivity and promoting cell survival.

The results connect multiple observations about how the hormone adiponectin functions and eventually could lead to new treatments for conditions ranging from diabetes and weight loss to heart disease and cancer.

"Until now, there wasn't really an obvious connection between all these different phenomena," said Dr. Philipp Scherer, professor of internal medicine and cell biology and senior author of the study appearing online today and in a future edition of Nature Medicine.

In this study, the researchers used models of inducible cell suicide in both pancreatic beta cells, which produce insulin, and cardiomyocytes, which are specific muscle cells located in a part of the heart known as the myocardium, to determine how the single hormone could exert such different influences.

"This paper shows that the common theme among all these different activities relies on adiponectin's interaction with a specific subset of lipids known as ceramides," said Dr. Scherer, who directs the Touchstone Center for Diabetes Research.

Ceramides are a family of lipid molecules known to promote cell suicide, or apoptosis. High levels of ceramides have been shown to promote diabetes by sabotaging signaling pathways induced by insulin and killing beta cells.

When the researchers introduced adiponectin into cells, they found that the hormone triggers the conversion of ceramides from a destructive force into one that helps cells survive and inhibits cell death.

"Adiponectin essentially provides a makeover of this ugly cousin," Dr. Scherer said.

Dr. William Holland, lead author and postdoctoral fellow in internal medicine, said the new findings ha
'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. CHOP experts collaborate in gene survey of childhood brain cancer; intriguing clues found
2. Fat yet muscular mouse provides clues to improving cardiovascular health
3. New 3-D model of RNA core domain of enzyme telomerase may offer clues to cancer, aging
4. New Clues to Possible Genetic Basis for ADHD
5. New Clues to Treating Ovarian Cancer Relapse
6. Hurts so good -- neural clues to the calming effects of self-harm
7. Long-Term Type 1 Diabetes Survivors Give Clues to the Disease
8. More Clues To Fibromyalgia Pain
9. Gene Mutation Offers Clues to Tamoxifen-Blood Clot Link
10. New Clues for Treating Ulcerative Colitis
11. Gene Mutations Offer Clues to Autoimmune Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... 2014 Natural Clear Vision , a ... his own vision from legally blind to perfect 20/20 vision ... review. , “There is a huge portion of the ... function, and most people just think that’s the way it ... that can be pretty risky at times,” reports Michaels. “This ...
(Date:8/22/2014)... deletion in advanced non-small cell lung cancer (NSCLC) ... in epidermal growth factor receptor (EGFR) tyrosine kinase ... BIM deletion independently predicts overall survival (OS) of ... activate the programmed cell death also known as ... been detected in 12.8% of the Asian population ...
(Date:8/22/2014)... (RA), a complex autoimmune disease that affects 1 ... not only cope with pain, disability and joint ... work, family life and marital functioning. While many ... and disability is common. In addition, some patients ... or side effects. Because of this, there is ...
(Date:8/22/2014)... London, UK (PRWEB) August 22, 2014 ... more magnetic for some clinical applications due to ... of the emerging innovations in ultrasound, such as ... imaging, are expected to keep the market moving ... as increasing mobility can enhance not only the ...
(Date:8/22/2014)... Wisconsin (PRWEB) August 22, 2014 Mueller ... for Plantar Fasciitis, an exciting new product that provides ... you to stay active while you heal. The package ... is truly a new technology – it is not ... , FasciaDerm® PFTape™ System for Plantar Fasciitis ...
Breaking Medicine News(10 mins):Health News:Natural Clear Vision: Review Exposes Kevin Richardson’s Program for Restoring Vision Naturally 2Health News:Deletion predicts survival in advanced non-small cell lung cancer 2Health News:Study shows cognitive-behavioral coping skills training has positive effects on rheumatoid arthritis 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 3Health News:Mueller Introduces FasciaDerm® PFTape™ System for Plantar Fasciitis 2
... BASKING RIDGE, N.J., Oct. 19 Hooper Holmes,Inc. ... a proven, standard,method for acquiring the additional health ... applicants. Mature Assessment reflects the trend of ... increased willingness to insure them.,To address these customers, ...
... Skin Treatment to Treat All ... BARRINGTON, Ill., Oct. 19 Steroids have been in ... must be reasons why,people use steroid products on a regular ... of the human body, and it needs to stay healthy. ...
... Host Conference Call and Webcast Same Afternoon, DENVER, ... of functional foods, beverages and nutritional,supplements, today announced that ... the three and nine months, ended September 30,2007, on ... a teleconference the same afternoon beginning at,4:15 PM Eastern ...
... XI,AN, China, Oct. 19 /Xinhua-PRNewswire-FirstCall/ -- Mr. Weibing ... (OTC,Bulletin Board: SKBI) ("Skystar") will be featured in ... 24, 2007, at 10:30 a.m.,EST. The interview will ... p.m. EST on,October 24. The interview will ...
... drug is given just once per month, experts say , ... treating anemia in patients with severe kidney disease could help ... , Compared with conventional therapy, giving patients an anti-anemia drug ... concluded Dr. Nathan Levin, of the Renal Research Institute in ...
... ... at TCT 2007 ... Oct. 19 Stereotaxis, Inc. (Nasdaq:,STXS) announced today that it will ... at the,Transcatheter Cardiovascular Therapeutics (TCT) symposium in Washington,D.C., October 20 to ...
Cached Medicine News:Health News:Hooper Holmes Introduces Mature Assessment 2Health News:Steroids Are Abused for Skin, Not Just Muscles 2Health News:XELR8 Holdings to Announce 2007 Third Quarter Results on Wednesday, October 31, 2007 2Health News:XELR8 Holdings to Announce 2007 Third Quarter Results on Wednesday, October 31, 2007 3Health News:Skystar Bio-Pharmaceutical Announces Upcoming Interview With WallSt.net ( www.wallst.net ) 2Health News:Simpler Anemia Treatment May Help Kidney Patients 2Health News:Stereotaxis Showcases Interventional Cardiology Capabilities of Niobe Magnetic Navigation System 2Health News:Stereotaxis Showcases Interventional Cardiology Capabilities of Niobe Magnetic Navigation System 3Health News:Stereotaxis Showcases Interventional Cardiology Capabilities of Niobe Magnetic Navigation System 4
(Date:8/21/2014)... 2014   Memorial Hermann Health System and ... announced a new partnership to provide a new level of ... centers in the greater Houston area. ... the exclusive provider of professional breast radiology services for five ... City, The Woodlands , Northeast, Southwest and ...
(Date:8/21/2014)... Aug. 21, 2014 Nektar Therapeutics (NASDAQ: ... today announced positive results from its Phase 3 ... extended half-life recombinant factor VIII (rFVIII) treatment for ... which met its primary endpoint in reducing annualized ... to the on-demand arm. Top-line results ...
(Date:8/21/2014)... , Aug. 21, 2014 The spinal column ... the human body. Signals carried to and from the brain ... skills and nervous system. Injury or ailment here can be ... with a loss of control over their body. Though back ... a person,s life, there are more options available to make ...
Breaking Medicine Technology:Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2
... CHAPEL HILL, N.C., Sept. 24 As the bio-pharmaceutical ... area of Oncology are tailoring their market education strategies ... their therapeutic area. Leading organizations have found that a ... product launch as KOLs, physicians, and payers in the ...
... WASHINGTON, Sept. 24 OrbusNeich today announced at the ... of patient enrollment in the randomized clinical trial of ... 183 patients included at sites in Asia, Australia, Europe ... this study represents a significant milestone as we look ...
Cached Medicine Technology:Effectively Educating the Marketplace to Support a Successful New Oncology Product Launch 2Patient Enrollment Completed in First Randomized Clinical Study of OrbusNeich's Combo™ Bio-engineered Sirolimus Eluting Stent 2Patient Enrollment Completed in First Randomized Clinical Study of OrbusNeich's Combo™ Bio-engineered Sirolimus Eluting Stent 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: