Navigation Links
New clues to the structural dynamics of BK channels
Date:7/14/2011

BK channels (large-conductance, Ca2+-dependent K+ channels) are essential for the regulation of important biological processes such as smooth muscle tone and neuronal excitability. New research shows that BK channel activation involves structural rearrangements formerly not understood. The study appears in the August 2011 issue of the Journal of General Physiology.

Previous research pointed to a possible unified theory of activation gating in K+ channels, with the "activation gate" formed by the bundle crossing of four S6 transmembrane helices from the four subunits. Recent studies, however, have suggested a different structure for BK channels, but the exact location of the activation gate remained a mystery.

A new study by Xixi Chen and Richard Aldrich (The University of Texas at Austin) provides important clues to this question. The research identifies a single residue M314, halfway down S6, that appears to change conformation during the opening of the BK channel, rotating its side chain from a position in the closed state not exposed to the hydrophilic pore to one that is so exposed in the open state. The results further show that M314 might not actually form the part of the activation gate that blocks ion passage, but that motions in the deep pore may be required for blocking ion passage elsewhere in the channel.

The findings point to new directions for research regarding the molecular mechanisms of BK channel activation, according to Commentary by Daniel Cox (Tufts University School of Medicine) and Toshinori Hoshi (University of Pennsylvania). Importantly, they say, the study demonstrates that BK channel activation is not an open-and-shut case as previously suspected.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related medicine news :

1. Tiny fruit fly could offer big clues in fight against obesity, researcher says
2. Chickens May Provide Clues to Color Vision
3. New clues found linking larger animals to colder climates
4. New Clues to Lupus Link With Heart Disease
5. Blood Gives Clues to Executive Thinking Problems
6. Clues to pregnancy-associated breast cancer found
7. Clues Found to How Different Flu Vaccines Work
8. New Clues to Pregnancy-Associated Breast Cancer
9. Scientists Find Clues to How the Body Fights Off HIV
10. More Clues Emerge on How HIV Infects Women
11. Lab that probes genetic clues to disease is poised for major expansion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... ... California, will be included in the 2016 “Guide to America’s Top Plastic Surgeons” ... on the amalgamation of their education, experience, and professional associations. , One ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... veterinarian diagnostic imaging systems and the first company to offer robotic ... a Heart at their tradeshow booth # 941 for the American Association of ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... journeys, announced today that it has raised $6.0 million in an initial round ... Clarify Health’s conviction that patients and their caregivers can receive far better care ...
(Date:11/30/2016)... ... November 30, 2016 , ... The ... been designated as a Cigna Infertility Center of Excellence. The Cigna Center of ... , “It’s an honor to be designated a Cigna Infertility Center of Excellence," ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... health treatment has announced the opening of a new residential mental health treatment ... with mental health issues such as severe anxiety, depression, bi-polar disorder, and other ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... , Dec. 2, 2016 The U.S. ... for Jardiance (empagliflozin) to reduce the risk of cardiovascular ... and cardiovascular disease. "Cardiovascular disease is ... 2 diabetes mellitus," said Jean-Marc Guettier , M.D., ... Products in FDA,s Center for Drug Evaluation and Research. ...
(Date:12/2/2016)... December 2, 2016 Persistence Market ... market in its upcoming report titled, "Global Market Study on Cardiac ... CAGR of -1.4% between 2016 and 2024". The global cardiac ... 2015 and this is likely to decline to US$ ... global cardiac pacemaker market is anticipated to exhibit a ...
(Date:12/2/2016)... 2016 According to the latest market ... on Automated Endoscope Reprocessors: Single Basin Automated Endoscope Reprocessors Product ... 2016 and 2024 " the global automated endoscope reprocessors market was valued at ... at a CAGR of 7.2% during an eight-year forecast period ... by 2024. ...
Breaking Medicine Technology: