Navigation Links
New clues to molecular understanding of autism
Date:9/12/2011

p>The UB scientists say that this research paves the way toward understanding autism on the molecular level, a critical component that has not yet been sufficiently explored.

"As long as autism is diagnosed by a set of behaviors, it will be an ill-defined condition," explains Rasmusson, who brings to the research a personal understanding of the condition's behavioral aspects, since his son is severely affected by autism spectrum disorder.

"Once we start to determine some definitive biomarkers, possibly, as this research suggests, calcium handling indicators, we will be able to appreciate the differences between how different individuals present with this condition," he says.

That understanding will have implications for treatments, too, because as the researchers point out, while 75 to 80 percent of patients with the mutation were diagnosed with autism, 20 percent did not.

"Once we determine how TS is related to being diagnosed with autism spectrum disorder, we have an opportunity to explore how that 20 percent of individuals manage to override the mutation's effect," says Glenna C.L. Bett, PhD, professor and vice chair of the Department of Gynecology-Obstetrics, professor of physiology and biophysics in the UB medical school and co-author on the PNAS paper. "Those mechanisms are likely to play a key role in developing interventional therapies for autism spectrum disorder."

The research also has the potential to help in modeling and understanding other psychiatric disorders, such as bipolar disorder and substance abuse and dependence.

Bett and Rasmusson were originally conducting research on calcium channels and their effects on heart function when they learned of research published in late 2004 showing that this single mutation in the L-type calcium channel could lead to Timothy Syndrome. At that point, they knew that developing a model of TS would be key to understanding the importance of this calcium channel
'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New X-Rays Offer Clues on Evolution of the Human Brain
2. Mouse Study Could Give New Clues to Fighting Baldness
3. Gene gives clues to self-injurious behavior in rare disorder
4. Early-stage melanoma tumors contain clues to metastatic potential
5. New clues to the structural dynamics of BK channels
6. Gene study offers clues on memory puzzle
7. Research in fish provides new clues about deadly form of liver cancer
8. New clues to the cause of Alzheimers disease
9. Gene Map of Ovarian Cancer Yields New Clues to Treatment
10. Duke team finds new clues to how cancer spreads
11. Stem cell model offers clues to cause of inherited ALS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 20, 2014 With a mere 19 ... Crist made a brief fundraising stop at the ... , Fresh from a debate last night with his ... stage for the first seven minutes because Crist had ... described the incident in one word: "weird." , Before ...
(Date:10/20/2014)... October 20, 2014 T.E.N., a ... firm, announced today that William H. Murray, renowned ... 2014 ISE® Luminary Leadership Award winner. Presented annually, ... of an outstanding leader and industry practitioner for ... in advancing the information security industry. , Formerly ...
(Date:10/20/2014)... Principle Business Enterprises, a family owned company ... absorbent products. The company has recently made efforts ... Tranquility® Premium Protection absorbent products. The company has ... packaging a new look, and is currently working on ... public. , The new website, developed with Thread Marketing ...
(Date:10/20/2014)... Collins, CO (PRWEB) October 20, 2014 ... dGH assays are the only imaging assays capable ... in a single test.  With these three dimensions ... their ability to detect the widest range of ... translocations—mutations usually missed by other genomic tools, including ...
(Date:10/20/2014)... York, NY (PRWEB) October 20, 2014 ... be introduced in the U.S., has a lot to celebrate ... when our country recognizes the achievements and contributions of Americans ... the anniversary for Punzoné, and today it shares its favorite ... take a trip to Italy - even if it is ...
Breaking Medicine News(10 mins):Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:KromaTiD Launches Genome Screening and Discovery Services 2Health News:KromaTiD Launches Genome Screening and Discovery Services 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4
... earlier research involving hormone therapy , , WEDNESDAY, April ... therapy appear to have a 28 percent reduction in ... found. , But researchers don,t yet know why the ... women remains the same: Take hormone replacement therapy at ...
... young baseball playersROSEMONT, Ill., April 22 For generations, baseball ... for kids to get some exercise along with their first ... of Orthopaedic Surgeons ( http://www.aaos.org ) (AAOS) urges ... , ...
... celebritiesParis Hilton, Nicole Ritchie, Michelle Rodriguez and Lindsay Lohanyielded ... any public health context, according to a new report ... Public Health,s Center for Injury Research and Policy. Analyzing ... and the evening news broadcasts from ABC, NBC, CBS, ...
... heavier people produces more greenhouse gases, researchers say , , ... does more than protect your health. It also ... London School of Hygiene & Tropical Medicine say that ... gases, a lean population, such as in Vietnam, consumes ...
... Newly established CandleInTheWindow.org announces a $1,000 scholarship/award for ... pregnant women in need that the bearer of the symbol ... to get beyond the labels of Pro-life and Pro-choice and ... Everyneighborhood, USA there are hundreds of people right ...
... School of Medicine and the Moores UCSD Cancer Center have ... to be part of the first line of defense against ... found that when these cells, known as lymphocytes, make an ... likely to spread to the lungs. , They have ...
Cached Medicine News:Health News:HRT May Protect Women From Colon Cancer 2Health News:Swing That Bat Into Baseball Season, Injury Free 2Health News:Swing That Bat Into Baseball Season, Injury Free 3Health News:Media ignores health consequences of drinking and driving among young celebrities 2Health News:Staying Slim Is Good for the Environment 2Health News:$1000 Scholarship/Award for Best Poster/Ribbon Design That Encourages Needy Pregnant Women to Ask Bearers for Help 2Health News:Instead of fighting breast cancer, immune cell promotes its spread 2
(Date:10/20/2014)... 20, 2014  Luoxis Diagnostics, Inc., a subsidiary ... announced that its academic collaborators will present several ... for its novel RedoxSYS Diagnostic System, a first-in-class ... body in response to injury or illness.  A ... a clinical marker will be presented by ...
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., a ... antibodies, today announced the appointment of Marco ... Londei will lead the preclinical and clinical development ... "We are pleased to welcome Dr. Londei to ... , President and Chief Executive Officer of AnaptysBio. ...
(Date:10/20/2014)... DENVER , Oct. 20, 2014   Mary,s ... Foundation for Caring, is a 4-Star Sponsor of ... providing Veterans with unique products, programs and services to ... our freedom. Key Facts: , ... marijuana is a safe and effective treatment for pain, ...
Breaking Medicine Technology:Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 2Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 3Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 4Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 5AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 3
... -Memory to Host Conference ... and BASEL, Switzerland, May 2 ,Memory Pharmaceuticals Corp. (Nasdaq: ... Roche has exercised its option to further develop and,commercialize ... for neurological and psychiatric disorders. Roche,s,exercise of its option ...
... for More Targeted Asthma Control, MENLO PARK, ... announced today that it has begun shipments of ... March 2008, the Insight eNO,System combines the accuracy, ... provide office-based measurements of exhaled,nitric oxide (eNO). Exhaled ...
Cached Medicine Technology:Roche Exercises its Option to Further Develop and Commercialize Memory Pharmaceuticals' Nicotinic Alpha-7 Agonist, MEM 3454 2Roche Exercises its Option to Further Develop and Commercialize Memory Pharmaceuticals' Nicotinic Alpha-7 Agonist, MEM 3454 3Roche Exercises its Option to Further Develop and Commercialize Memory Pharmaceuticals' Nicotinic Alpha-7 Agonist, MEM 3454 4Apieron, Inc. Begins Customer Shipments of the Insight(TM) eNO System 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: