Navigation Links
New clues to healing arthritis caused by traumatic injury
Date:2/22/2009

id Bridgette Furman, research analyst and lead scientist of this study. "We thought, 'if they can regenerate cartilage in the ear, what about cartilage in the knee?' This happened in our pilot study, and we now have taken these results further and learned what happens in terms of inflammation. If you can figure out why the animal is a superhealer and apply that to people, then you may help prevent the development of arthritis."

In the latest experiment, the team got very clear results in the genetic response within injured tissue: the control mice showed a greater than 700-fold increase in the expression of one cytokine, interleukin(IL-1β) in the first four hours after a fracture and 37-fold difference in that cytokine level at 7 days after the fracture. Cytokines are signaling molecules produced by cells in response to injury. Interleukin generally promotes inflammation and an increase in temperature. The superhealer mice showed a similar trend, but in much lower amounts: a 70-fold peak in expression at day 0 down to a 3.5-fold increase by day 7.

A second cytokine, TNF-α, was also expressed at a significantly higher rate in the control mice after the fracture (from a 13-fold peak just after fracture to 5-fold at 7 days), while the superhealer mice showed no change in their levels of TNF-α at all over time.

"Current treatments on the market for rheumatoid arthritist include anakinra (Kineret, an IL-1 receptor antagonist) and etanercept (Enbrel, a tumor necrosis factor blocker)," said Farshid Guilak, Ph.D., study scientist and director of the Orthopaedic Bioengineering Laboratory in the Duke Department of Surgery. "In future studies, we plan to use these rheumatoid arthritis drugs right after a fracture to inhibit inflammatory cytokines in the normal mice. If a reduced inflammatory response is what helps the superhealers, we would like to know whether controlling inflammation in fracture patients can prevent arthritis."


'/>"/>
Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mutant rats offer clues to medical mystery
2. New Clues to Stopping Colitis-Linked Cancer
3. Physics, Math Provide Clues to Unraveling Cancer
4. Worm provides clues about preventing damage caused by low-oxygen during stroke, heart attack
5. Study yields clues about the evolution of epilepsy
6. Mutant Mouse Gene Offers Clues to Hearing Loss
7. Study provides clues to preventing and treating cancer spread
8. Migraine mutations reveal clues to biological basis of disorder
9. Research Uncovers Clues to Lymphoma
10. Finding clues for nerve cell repair
11. Study Offers Clues to Link Between Arrhythmia, Sudden Death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, 2014 (HealthDay ... work commitment is a big reason why, new research suggests. ... Mathias Basner, an assistant professor of sleep and chronobiology in ... A time-use survey of nearly 125,000 Americans, ages 15 ... exchanged for sleep. Short sleepers -- those who slept six ...
(Date:12/15/2014)... December 15, 2014 South Florida’s leading urgent ... holidays can be a daze of hassle, hustle, and bustle ... while decking halls, to burns when making special meals and ... that can happen at any time. To prevent this season ... has made a list of helpful and healthful holiday tips ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Fostering innovation to speed the improvement of health care ... researchers at Cincinnati Children,s Hospital Medical Center. "The ... broken," says Peter Margolis, MD, PhD, co-Principal Investigator of ... our previous successes, is to create a totally new ...
... , , , ... today that it has changed its corporate name to Ocular Therapeutix, ... more clearly articulates our mission in the ophthalmic marketplace as we ... and develop ocular drug delivery therapies." , , ...
... the psychological distress and burnout experienced by many physicians ... Center researchers report in today,s issue of the ... ). The training also can expand a physician,s ... according to the researchers, who were led by Michael ...
... , Former Vermont Governor to sign new book ... Sept. 23 -- Governor Howard Dean will be in Philadelphia, PA and ... and sign copies of his new book, Howard Dean,s Prescription for Real ... at the Philadelphia Free Library for a noon book signing and discussion. ...
... , , , , ... & Lione, one of the largest intellectual property law firms in the U.S., ... its long-time client Cook Incorporated in a patent infringement case brought by Edwards ... Appeals for the Federal Circuit affirmed the previous ruling of the U.S. District ...
... though, that biggest risk factor is the brain attack itself ... reduce the chances of developing dementia such as Alzheimer,s disease ... concentrating on all the known stroke risk factors, a new ... analysis of 30 previous studies that involved more than 7,500 ...
Cached Medicine News:Health News:Open innovation networks are one key to improved care 2Health News:Open innovation networks are one key to improved care 3Health News:Open innovation networks are one key to improved care 4Health News:Open innovation networks are one key to improved care 5Health News:Mindful meditation, shared dialogues reduce physician burnout 2Health News:Mindful meditation, shared dialogues reduce physician burnout 3Health News:Mindful meditation, shared dialogues reduce physician burnout 4Health News:Brinks Hofer Gilson & Lione Wins Patent Appeal for Cook Incorporated 2Health News:Brinks Hofer Gilson & Lione Wins Patent Appeal for Cook Incorporated 3Health News:Preventing Second Stroke May Stave Off Dementia 2Health News:Preventing Second Stroke May Stave Off Dementia 3
(Date:12/17/2014)... December 17, 2014 Revenue and earnings ... on research and development In the past 2013/14 ... by two percent to EUR 4.287 billion (last year: EUR ... 14 percent to EUR 360 million. "Overall, 2013/14 was a ... Michael Kaschke , President and CEO of Carl Zeiss AG. ...
(Date:12/17/2014)... 2014  Beamz Interactive, Inc. (OTCQB: BZIC), a ... announced that it has signed an agreement with ... of innovative prosthetic, orthotic and assistive technology products ... agreement, RSL Steeper will promote and supply the ... use within UK residential care facilities through its ...
(Date:12/17/2014)... , Dec. 17, 2014  RXi Pharmaceuticals Corporation ... focused on discovering, developing and commercializing innovative therapies ... today announced completion of enrollment in its first Phase ... 3-month observations confirmed the 1-month findings that were ... Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO , ...
Breaking Medicine Technology:ZEISS Asserts its Position in Difficult Environment 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5
Straight chisel for scoring, cutting, scraping, cleaning and sculpting bone....
Custom-made chisels....
Lewin Bone Forceps, serrated and slightly curved. To hold, stabilize, rotate, reduce and,compress bone....
To elevate, dissect, scrape and apply traction to bone and soft tissue....
Medicine Products: