Navigation Links
New clues to healing arthritis caused by traumatic injury
Date:2/22/2009

DURHAM, N.C. - A strain of laboratory mice that has "superhealing" powers has been found to resist inflammation after a knee injury, and also to avoid developing arthritis at the injury site in the long term, according to researchers at Duke University Medical Center. Their findings illuminate the mechanisms of post-traumatic arthritis and could point to therapies for this condition, which commonly afflicts younger people who lose productivity during their prime working years.

"After a patient's traumatic injury, orthopaedic surgeons realign the joint surface as anatomically as possible and then hope for the best," said Steven A. Olson, MD, FACS, principal investigator of the post-traumatic arthritis project and chief of the Duke orthopaedic trauma section. "They haven't been thinking about why patients with injuries are subsequently getting arthritis. Our research examines how we could possibly prevent arthritis development with growth factors and anti-inflammatory therapies after a fracture, either before or at the time of the surgery to fix it."

Olson said 10 percent of all arthritis cases - about 4.6 million - are post-traumatic arthritis patients, many of whom suffer for years and are too young for joint replacement surgeries. The economic cost thus is about $12.8 billion annually for this group, according to Arthritis Foundation statistics.

The scientists examined the differences in inflammatory response between two types of mice: one type known as superhealers (or MRL/MpJ) versus a strain of control mice (C57BL/6).

Previously, scientists discovered that the superhealer mice had such regenerative powers that holes made in their ears for lab identification purposes grew over completely with no sign of scar tissue. Earlier work done at Duke showed no differences between healthy and fractured limbs when the superhealers healed from a fracture of the knee joint.

"The superhealer can almost regenerate tissue," sa
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mutant rats offer clues to medical mystery
2. New Clues to Stopping Colitis-Linked Cancer
3. Physics, Math Provide Clues to Unraveling Cancer
4. Worm provides clues about preventing damage caused by low-oxygen during stroke, heart attack
5. Study yields clues about the evolution of epilepsy
6. Mutant Mouse Gene Offers Clues to Hearing Loss
7. Study provides clues to preventing and treating cancer spread
8. Migraine mutations reveal clues to biological basis of disorder
9. Research Uncovers Clues to Lymphoma
10. Finding clues for nerve cell repair
11. Study Offers Clues to Link Between Arrhythmia, Sudden Death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... Warminster, PA (PRWEB) July 12, 2014 ... Paddock covering a variety of men’s health questions. ... issues specific to men, why women live longer than ... article, Men's Health Made Simple featured on ... can get a hernia at any age. If you ...
(Date:7/12/2014)... A recent article released by Seattle's well known plastic ... those seeking cosmetic surgical procedures in summer months . ... heat begins to enliven the rainy Pacific Northwest, many people ... they didn’t work out as much during the winter as ... surge of people eager to look their best for their ...
(Date:7/12/2014)... 2014 Floor-grade instrument ... out of 5. This above-average score represents favorable ... buyer negotiation power over the three years to ... “during the period, surging demand for healthcare services ... new product development, have placed upward pressure on ...
(Date:7/11/2014)... (PRWEB) July 12, 2014 Recently, MagicQuinceaneraDresses.com, ... released its new collection of 2014 Quinceanera dresses ... those who want to look fashionable without paying a ... discounted prices, up to 57% off. , The company’s ... ladies to get amazing special occasion outfits. In addition ...
(Date:7/11/2014)... 11, 2014 Ticket Down reports that tickets ... and 3rd place World Cup Match between Brazil and ... will take place on Saturday, July 12th at Estadio Nacional ... Finals will take place on Sunday, July 13th at Estadio ... All tickets for the 2014 World Cup are guaranteed to ...
Breaking Medicine News(10 mins):Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2Health News:Best Summer Cosmetic Surgeries Revealed in Article By Seattle Plastic Surgeon 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 4Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2
... -- When it comes to aggressive courtship strategies, sexist men ... research suggests. U.S. researchers conducted two surveys: One included ... other was a national Internet poll of 850 adults. ... attitudes toward women and whether they were willing to engage ...
... Many teens with autism rely on school-based mental health services, ... 10-year study of more than 920 adolescents with an autism ... were aged 13 to 17 when the study began in ... autism used a mental health service in the past year ...
... to tobacco smoke miss more days of school than do ... The report from investigators at Massachusetts General Hospital ... respiratory illnesses that can be caused by second-hand smoke and ... has been released in the online edition of Pediatrics. ...
... obesity is widely viewed as contributing to type 2 ... Hospital Boston report that two proteins activated by inflammation ... and that boosting the activity of these proteins ... mice. The research, led by Umut Ozcan, ...
... (HealthDay News) -- For some children, the start of school ... deal with the problem, bullying is a persistent issue in ... Forest University in Winston-Salem, N.C. "The goal is to ... live in a world that accepts violence, intimidation and power ...
... (HealthDay News) -- A trend toward a longer allergy season ... experts say. Allergy season used to run from mid-August ... such as itchy eyes and stuffiness are starting earlier and ... Asthma & Immunology (AAAAI). The main culprit ...
Cached Medicine News:Health News:Sexist Men, Women May Be a Good Fit: Study 2Health News:Study confirms that living with a smoker increases absenteeism in school children 2Health News:Study confirms that living with a smoker increases absenteeism in school children 3Health News:New tactic for controlling blood sugar in diabetes contradicts current view of the disease 2Health News:Making Sure 'Back to School' Doesn't Mean 'Back to Bullying' 2
(Date:7/10/2014)... Virginia , 11. Juli 2014 ... von Kameras für die molekulare Bildgebung, ... hat heute die CE-Zulassung für sein ... CE-Zeichen kann Dilon das Produkt jetzt ... auf den Großteil der europäischen Länder ...
(Date:7/10/2014)... 2014  Breg, Inc., a premier provider of ... FreeRunner™ knee brace with new innovations to help ... return to active lifestyles.  FreeRunner,s patent-pending design acts ... support when patients need it most, and the ... Patellofemoral issues are the most common cause ...
(Date:7/10/2014)... , July 10, 2014  RESMED INC. (NYSE: ... quarter and fiscal year ended June 30, 2014 results on ... market close. A press release with ResMed,s results will be ... will host a webcast to discuss operating results and future ... at 1:30 p.m. US Pacific Time and the live webcast ...
Breaking Medicine Technology:Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... technology has enabled more and more laboratory testing to ... laboratory is hardly threatened with extinction. National volume data ... ever before, and the huge range of their capabilities, ... volumes of tests assures them an abiding and pivotal ...
... S. Singer, M.D., Ph.D. Harvard Medical School ,Contributing ... and 40,000 deaths per year, breast cancer undoubtedly ... problems. Recently, efforts to develop early detection ... progress. This is particularly true at the ...
Cached Medicine Technology:Immunoassay Systems - Your Laboratory Workhorse 2Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy 2Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy 3
The PDC Smart® Key Fob can be programmed on demand using a 13.56 MHz RFID reader/writer and is ideal for long-term use applications such as electronic access control or loyalty programs....
... provide healthcare professionals witha patient'sname and ... speak, cant remember, oris unconscious. VeriMed ... individuals. The application can help these ... comparable level of care by rapidly ...
... The optional Kisses component of ... to assist nursing staff in ... while in the hospital. ... have an easy, effective and ...
VerdaSee Portal ID is a family of solutions that provide automated tracking and tracing of assets as they enter or leave designated areas within a healthcare facility....
Medicine Products: