Navigation Links
New clues to breast cancer development in high-risk women
Date:9/11/2007

Furth, MD, the studys senior author and a professor of oncology at Georgetown. The cells that develop into cancers frequently lose their ability to express the estrogen receptor and therefore are not sensitive to anti-estrogen therapies.

Although the molecular mechanisms to explain this loss of sensitivity are not yet clear, the researchers believe that the BRCA1 mutation is causing the estrogen signaling pathway to malfunction, ultimately making these tumors harder to treat.

The findings also explain why the small proportion of women who have had an oophorectomy and still develop breast cancer frequently have tumors that are unresponsive to anti-estrogens like Tamoxifen, said Furth.

Both breast and ovarian cancers are often stimulated by estrogen, so oncologists counsel women who are over the age of 35 and know they carry a BRCA mutation to remove their ovariesthe bodys major source of estrogento reduce their chances of developing breast cancer and virtually eliminate risk of ovarian cancer, she explained.

Women with a BRCA1 mutation develop breast cancers that are most often unresponsive to hormones and anti-hormonal therapies like Tamoxifen, said Furth, but doctors continue to see reduced incidence of breast cancer among high-risk women who have undergone the oophorectomy procedure.

The finding that estrogen is important in the development of BRCA1 mutant breast cancers is one of the strongest pieces of evidence to support removing the ovaries to reduce incidence of cancer in BRCA1 mutation carriers, said co-author Eliot Rosen, MD, PhD, professor of oncology, biochemistry & cell and molecular biology, and radiation medicine at Georgetown.

The research also explains why oophorectomy appears to be more effective for younger women than older women, he said. This study demonstrates that estrogen is important to the early development of cancer, said Rosen. Women who have lost BRCA1 function need estrogen to generat
'/>"/>

Contact: Becky Wexler
rjw43@georgetown.edu
202-687-5100
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. New clues about immune system from leprosy microbes
2. New clues to maternal aggressive behavior
3. Monkeys offer genetic clues to adult blindness
4. Innovative yeast genome may handle Cancer Clues
5. Researchers Discover New Clues To Identify Tooth Decay
6. Leeches Provide Clues Regarding The Prevention Of Heart Disease
7. Excavations Reveal Clues Of Early Warfare
8. Sleeping Computers Yield Clues About Genetic Disorders
9. Transporter offers reliable clues for safer pain medicine
10. Clues To Identify Psychological Seizures
11. A Human Brain Gene Could Hold Clues On The Evolution Of Brain Capacity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Women must play a greater role in resolving ... the subject of women and water. Water researcher and radio ... Water Partnership and United Nations-Water agree that when water issues ... was interviewed by Kleyne on the Sharon Kleyne Hour Power ... Kathy Kelly became involved with global water issues as a ...
(Date:8/28/2014)... August 28, 2014 It is not uncommon ... of unsuccessful dieting attempts. Many face ridicule and judgment and ... their thoughts and feelings, wondering why they keep gaining weight ... find solace in comfort foods, eating more and gaining more, ... self-control. , Diet Doc has helped thousands safely, successfully ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 The Baltimore ... web design firms in Baltimore and awarded The ... on 2013 revenue from Web design, The Canton Group ... The Canton Group’s clients include Fortune 1000, higher education, ... organizations. The Canton Group specializes in web design and ...
(Date:8/28/2014)... 2014 Edvance360 , a leading ... tools for online teaching, as well as 2011 winner ... or Learning Management System, announced that Brooke Education Services, ... Treatment Center of America, Metis Leadership Group, Interactive Advertising ... to the user community. , “We are delighted ...
(Date:8/28/2014)... 28, 2014 Every year, cataracts affect over ... considered the leading cause of blindness in the world. Characterized ... behind the iris, cataracts are estimated to affect an additional ... an aging population. Cataracts are just one of the many ... Michael Tracy of Carlsbad Eye Care screens patients for a ...
Breaking Medicine News(10 mins):Health News:Women for Water Partnership and Sharon Kleyne Call for Greater Women’s Role in Global Water Issues 2Health News:Women for Water Partnership and Sharon Kleyne Call for Greater Women’s Role in Global Water Issues 3Health News:Diet Doc’s Medical Weight Loss Programs Announce New Help for Patients Who Want to Overcome Depression Caused by Excess Weight 2Health News:Diet Doc’s Medical Weight Loss Programs Announce New Help for Patients Who Want to Overcome Depression Caused by Excess Weight 3Health News:The Canton Group is Recognized by the Baltimore Business Journal as the Largest Web Design Firm in Baltimore 2Health News:Edvance360 Continues to Experience Growth in Corporate, K-12, Health, and Non-Profit Sectors 2Health News:Cataract Awareness Month an Opportunity to Focus on Vision Care and Ocular Health 2
... , MOUNT PROSPECT, Ill., Dec. 28 On ... (NABP(R)) reached a bitter-sweet milestone in its ongoing review of ... 5,000 Internet drug outlets as Not Recommended. These sites -- ... been found to be out of compliance with pharmacy laws ...
... evolved from a beneficial organism, researchers say , MONDAY, Dec. ... genetic makeup of a germ that causes cavities, and shows ... the mouth. , The germ is known as ... for sitting in the gut and doing good things, like ...
... , , BIRMINGHAM, Ala., Dec. 28 Family ... simple resolutions and fun advice for staying heart healthy ... lipidologist (NLA), certified hypertension specialist (ASH), medical director of ... and Chief Medical Officer at Atherotech, Inc., developer of ...
... to self-consciousness as biggest factor standing in people,s way , MONDAY, ... and millions of Americans will resolve that this ... of January are so many of those resolutions broken? , New ... that people don,t know that exercise is good for them and ...
... , , CINCINNATI, Dec. 28 Resolutions ... country later this month, and for many people a resolution ... at Cincinnati Children,s Hospital Medical Center recommend this annual practice ... the cycle of resolutions -- make one, stick to it ...
... obsessive dieting -- but could also help fight obesity, experts ... applications that help modern-world dwellers find restaurants in Calcutta, calculate ... code may also fuel eating disorders. , In the ... behavior by allowing teens and young adults to constantly count ...
Cached Medicine News:Health News:5,000 Web Sites Selling Prescription Drugs Outside of Pharmacy Laws and Practice Standards 2Health News:5,000 Web Sites Selling Prescription Drugs Outside of Pharmacy Laws and Practice Standards 3Health News:Heart-Healthy ABC's for 2010 2Health News:Top Reasons Those 'Get Fit' Resolutions Don't Stick 2Health News:Top Reasons Those 'Get Fit' Resolutions Don't Stick 3Health News:Mom, in 2010 I Will... Parents Should Encourage Family Goals, Not New Year's Resolutions 2Health News:Phone Apps Dialing Up Eating Disorders 2Health News:Phone Apps Dialing Up Eating Disorders 3
(Date:8/27/2014)... , Aug. 27, 2014 Kewaunee Scientific Corporation ... of Directors increased its quarterly cash dividend by 9% ... per outstanding share, beginning with the dividend payable on ... close of business on September 8, 2014. ... in 1906, Kewaunee Scientific Corporation is a recognized global ...
(Date:8/27/2014)... -- Columbia Laboratories, Inc. (Nasdaq: CBRX ) ("Columbia" ... trial manufacturing, and advanced analytical and consulting services to ... at the upcoming Rodman & Renshaw 16 th ... New York . The Company will present ... at the New York Palace Hotel. ...
(Date:8/27/2014)... and NINGBO, China , Aug. ... Ningbo Menovo Pharmaceutical Co., Ltd, ("Menovo") today announced they ... of generic pharmaceuticals, primarily targeting the United ... agreement, Amerigen and Menovo will jointly develop products for ... . Menovo will be responsible for manufacturing API ...
Breaking Medicine Technology:Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2
... N.J., Feb. 15, 2011 Daiichi Sankyo, Inc. (DSI), ... facility in Bethlehem Township, Pennsylvania from Amcor, a global ... leverage existing resources to more cost-effectively supplement its operations ... expected to be operational in the summer or early ...
... MAHWAH, N.J., Feb. 15, 2011 Stryker Corporation,s Orthopaedics ... most recognizable names and personalities in professional golf, has ... of the sport and current member of the PGA ... Triathlon ® Knee System in November 2009 and ...
Cached Medicine Technology:Daiichi Sankyo, Inc. Acquires First US-Based Packaging and Manufacturing Facility 2Fred Funk Becomes Spokesperson for Stryker Orthopaedics 2Fred Funk Becomes Spokesperson for Stryker Orthopaedics 3
The perfect quick consult for the busy cardiologist, The Ultimate Echo Guide puts the most clinically essential information in an easy access format....
... a quick-lookup reference for ECG interpretation ... presents the basics (anatomy and physiology ... system of the heart, basic ECG ... algorithms, emergency medications, and comprehensive information ...
Dx/Rx: Heart Failure has tables and figures that summarize important clinical data and current professional society recommendations and up-to-date information for diagnosis and treatment of Heart Fai...
Topics include: ECG reading, ACLS (all the latest protocols and pearls), CHF, acute MI, cardiac testing, palpitations, pericarditis, arrhythmias, murmurs, athletes, valvular disease, endocarditis, sy...
Medicine Products: