Navigation Links
New clues in hunt for heredity in type 2 diabetes
Date:3/19/2013

Type 2 diabetes has strong hereditary tendencies and the genes we are born with cannot be changed. However, new research from Lund University in Sweden shows that we can modify the function of the genes through the epigenetic changes that take place in the course of life.

Epigenetic changes are usually described as a link between heredity and environment and come about as a result of factors such as ageing, chemicals, medication, diet, exercise and drugs.

Researchers have now demonstrated that half of the known genetic risk variants for type 2 diabetes can be influenced by epigenetic changes that in turn influence the function of the insulin-producing cells.

"This means that we gain a tool to influence the function of the risk genes, improve insulin release and thereby reduce the risk of diabetes", says Charlotte Ling at Lund University Diabetes Centre, who has today published a study on epigenetic effects in connection with type 2 diabetes in the journal Diabetologia.

The epigenetic factor that has been studied is a chemical change on the DNA strand following a certain pattern, known as DNA methylation.

"We have shown that 19 of 40 known genetic risk variants for type 2 diabetes are affected by DNA methylation, which in turn changes the function of the insulin-producing cells", says Charlotte Ling. "This is important. Many researchers have put a lot of time and resources into mapping our genome and finding genetic risk markers for diabetes and other diseases. We know that there are genetic variants that increase the risk of type 2 diabetes, but in most cases the reasons why this happens are still not known. The next step is to find this out and after this study of the genetic risk variants, we can say that in some cases the increased risk is probably due to varying degrees of DNA methylation."

The research group has studied insulin-producing cells from 84 deceased donors. This is the first epigenetic study to be carried out on the 40 risk markers for type 2 diabetes.

The present study shows that DNA methylation of genetic risk variants for diabetes influence the insulin-producing cells in various different ways, such as the amount of insulin they contain and the amount they are able to release into the blood stream.

"The next step in our work is to test whether we can reduce the risk of type 2 diabetes by changing the degree of DNA methylation in the genetic risk variants for the disease."


'/>"/>

Contact: Charlotte Ling
Charlotte.Ling@med.lu.se
46-706-145-146
Lund University
Source:Eurekalert

Related medicine news :

1. Study of half siblings provides genetic clues to autism
2. Ice Cream Headaches Might Offer Clues to Migraines
3. Research yields new clues to how brain cancer cells migrate and invade
4. Clues to Slacker Behavior Found in Brain, Study Says
5. Geisel researchers sift through junk to find colorectal cancer clues
6. New Clues to the Evolution of the Human Brain
7. Amazon Tribe Gives Clues to Heart-Healthy Lifestyles
8. Researchers at IRB Barcelona uncover new clues about the origin of cancer
9. Fossilized Teeth Hold Clues to Early Human Species Diet
10. Scientists discover new clues explaining tendon injury
11. New Clues to How HIV Infects Bodys Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... Vegas, Nevada (PRWEB) , ... June 24, 2016 ... ... Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing ... Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/24/2016)... , Belgium , June ... MKT: VNRX), today announced the appointment of Dr. ... of Directors as a Non-Executive Director, effective June ... Company,s Audit, Compensation and Nominations and Governance Committees.  ... Dr. Futcher will provide independent expertise and strategic ...
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
Breaking Medicine Technology: