Navigation Links
New clues in hunt for heredity in type 2 diabetes
Date:3/19/2013

Type 2 diabetes has strong hereditary tendencies and the genes we are born with cannot be changed. However, new research from Lund University in Sweden shows that we can modify the function of the genes through the epigenetic changes that take place in the course of life.

Epigenetic changes are usually described as a link between heredity and environment and come about as a result of factors such as ageing, chemicals, medication, diet, exercise and drugs.

Researchers have now demonstrated that half of the known genetic risk variants for type 2 diabetes can be influenced by epigenetic changes that in turn influence the function of the insulin-producing cells.

"This means that we gain a tool to influence the function of the risk genes, improve insulin release and thereby reduce the risk of diabetes", says Charlotte Ling at Lund University Diabetes Centre, who has today published a study on epigenetic effects in connection with type 2 diabetes in the journal Diabetologia.

The epigenetic factor that has been studied is a chemical change on the DNA strand following a certain pattern, known as DNA methylation.

"We have shown that 19 of 40 known genetic risk variants for type 2 diabetes are affected by DNA methylation, which in turn changes the function of the insulin-producing cells", says Charlotte Ling. "This is important. Many researchers have put a lot of time and resources into mapping our genome and finding genetic risk markers for diabetes and other diseases. We know that there are genetic variants that increase the risk of type 2 diabetes, but in most cases the reasons why this happens are still not known. The next step is to find this out and after this study of the genetic risk variants, we can say that in some cases the increased risk is probably due to varying degrees of DNA methylation."

The research group has studied insulin-producing cells from 84 deceased donors. This is the first epigenetic study to be carried out on the 40 risk markers for type 2 diabetes.

The present study shows that DNA methylation of genetic risk variants for diabetes influence the insulin-producing cells in various different ways, such as the amount of insulin they contain and the amount they are able to release into the blood stream.

"The next step in our work is to test whether we can reduce the risk of type 2 diabetes by changing the degree of DNA methylation in the genetic risk variants for the disease."


'/>"/>

Contact: Charlotte Ling
Charlotte.Ling@med.lu.se
46-706-145-146
Lund University
Source:Eurekalert

Related medicine news :

1. Study of half siblings provides genetic clues to autism
2. Ice Cream Headaches Might Offer Clues to Migraines
3. Research yields new clues to how brain cancer cells migrate and invade
4. Clues to Slacker Behavior Found in Brain, Study Says
5. Geisel researchers sift through junk to find colorectal cancer clues
6. New Clues to the Evolution of the Human Brain
7. Amazon Tribe Gives Clues to Heart-Healthy Lifestyles
8. Researchers at IRB Barcelona uncover new clues about the origin of cancer
9. Fossilized Teeth Hold Clues to Early Human Species Diet
10. Scientists discover new clues explaining tendon injury
11. New Clues to How HIV Infects Bodys Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2017)... ... , ... A May 8 article on CBCNews reports that nearly ... that are not responsive to antibiotics nevertheless obtain prescriptions for them. The article goes ... the problem both in Canada and the United States. Dr. Michael Farzam of House ...
(Date:5/27/2017)... ... ... From May 21-23, hearing healthcare professionals gained a competitive edge with training ... Syracuse Downtown Hotel in Syracuse, New York. , As EarQ’s technology partner, Oticon ... to help them stay ahead in the industry. At the event, EarQ members learned ...
(Date:5/26/2017)... ... May 26, 2017 , ... The American Parkinson ... more than eighty-nine grant submissions all vying for nearly $1,000,000 in funding that ... field.     , The American Parkinson Disease Association (APDA) is focused on advancing scientific ...
(Date:5/26/2017)... ... May 26, 2017 , ... Amir Qureshi, MD is ... powerfully versatile, patient-centric spinal cord stimulation system. The Nuvectra™ Algovita SCS System has been ... pleased to be the first in Arkansas to introduce the most powerful SCS system ...
(Date:5/26/2017)... , ... May 26, 2017 , ... ... delicatessen foods, is sharing bold recipes for Memorial Day entertaining that are sure ... , “Boar’s Head fresh sliced meats and cheeses featured in these refreshingly ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of the ... based on extensive data analysis from GHI,s hospitals database ... database for the region. The GHI database covers 86% of ... more than 130 data points for each institution in key ...
(Date:5/9/2017)... -- Demonstrating its commitment to representing research- based biopharmaceutical ... Research and Manufacturers of America (PhRMA) today approved ... have to meet new research and development (R&D) ... PhRMA. "By putting in place new ... message that being a member of PhRMA means ...
(Date:5/6/2017)... May 5, 2017   Provista , a proven leader ... 200,000 customers, today announced Jim Cunniff as the ... executive and business experience to Provista, including most recently serving ... California . He assumed his new role ... a great fit for Provista," says Jody Hatcher , ...
Breaking Medicine Technology: