Navigation Links
New class of drug kills lymphoma cells
Date:4/14/2010

NEW YORK (April 13, 2010) -- Researchers from the Sackler Center at Weill Cornell Medical College have designed a new class of drugs that targets BCL6, a master regulatory protein responsible for causing the most common type of non-Hodgkin's lymphoma.

Findings published in today's issue of Cancer Cell show that an experimental compound designed by a team of researchers from Weill Cornell Medical College, the University of Maryland and the Ontario Cancer Center at the University of Toronto may effectively block the cancer-causing actions of BCL6 by attaching to a critical "hot spot" on its surface, thus killing off the cancer cells.

"BCL6 mediates its cancer-causing actions by attaching to other proteins," explains Dr. Ari Melnick, associate professor of medicine from the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell Medical College. "Traditionally protein-protein interactions have been viewed as being too difficult to block with small-molecule drugs."

Accordingly, by observing the atomic scale structure of BCL6 attached to its partner proteins, Dr. Melnick and colleagues identified a critical "hot spot" that appeared to be amenable to designing a drug. Dr. Alexander Mackerell, from the University of Maryland, then used computational modeling to identify chemical structures that could attack this hot spot.

"We tested the ability of a large number of these chemicals to bind and block BCL6," said Dr. Melnick, "and then Dr. Gilbert Priv, from the University of Toronto, performed nuclear magnetic resonance and X-ray crystallography studies to show that a specific BCL6 inhibitor compound hit exactly in the center of the predicted hot spot. Our results show that given the right scientific approach it is quite possible to design drugs against key protein regulatory factors like BCL6."

Dr. Melnick's group showed that the BCL6 inhibitor wa
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Executive Chairman of Medifast Bradley T. MacDonald Graduates From Leadership Maryland Class of 2009
2. Abstinence-Only Classes Reduced Sexual Activity, Study Found
3. MessageSolution Unveils Enterprise Class Lotus Quickr Archiving Solution at IBM's Lotusphere 2010
4. $20,200,816.17 Settlement Fund Proposed for Blue Parking Placard Litigation to be Divided Among Class Members Who Submit a Valid Claim Form.
5. Class Action Suit Filed to Defend Rights of Children With Autism to Vital, Cost-Saving Treatment
6. David Ortiz Celebrity Golf Classic Nets More than $225,000 for Children in Need
7. Securities Class Action Filed by Shepherd, Finkelman, Miller & Shah, LLP on Behalf of Hemispherx Biopharma Securities Purchasers Between February 18, 2009 and November 2, 2009
8. Natural Products Association Issues Statement on DEAs Steroid Classification Action
9. Mexico City to Build World-Class Hub for Medical Research
10. A World-Class HR Master's Degree Is Now Within Reach – 100% Online
11. Hypnotist Offers $15,000 Stimulus Package to Atlanta's Middle Class to Kick Off 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... iFitDress.com, a well-known wedding dress manufacturer and ... 16 cocktail dresses . Included in the new range ... all of these charming outfits are offered at deeply ... has promised that all of the sweet 16 cocktail ... worth mentioning that all of them are set according ...
(Date:11/26/2014)... Alex Kramer HealthDay Reporter ... arthritis may be more likely to achieve remission if they ... The study found that those who were heaviest had almost ... lowered the odds of remission. "Medication for rheumatoid arthritis ... Susan Goodman, the study,s lead author and a rheumatologist at ...
(Date:11/26/2014)... Steven Reinberg HealthDay Reporter ... are smoking cigarettes than ever, health officials said. In ... 21 percent in 2005 to 18 percent in 2013. That ... to 42.1 million, despite the increasing population, according to the ... However,"we still have a long way to go, and if ...
(Date:11/26/2014)... NJ (PRWEB) November 26, 2014 ... Lourdes Cardiology have launched a partnership designed to ... rates for congestive heart failure (CHF) patients in ... Center staff and Lourdes Cardiology team will help ... and supervised protocols. This partnership pairs the Cardiac ...
(Date:11/26/2014)... San Francisco, CA (PRWEB) November 26, 2014 ... to hanker after cheap deals on Black Friday, which signifies ... taken to clicking items into their shopping carts in the ... rowdy crowds. , This Friday is going to ... sales in a day, with an estimated $2.48 billion in ...
Breaking Medicine News(10 mins):Health News:iFitDress.com: Trendy Sweet 16 Cocktail Dresses Unveiled 2Health News:Weight Could Influence Rheumatoid Arthritis Relief 2Health News:Weight Could Influence Rheumatoid Arthritis Relief 3Health News:U.S. Adult Smoking Rate Drops to New Low: CDC 2Health News:U.S. Adult Smoking Rate Drops to New Low: CDC 3Health News:Advanced Heart Failure Recovery Program comes to Deptford Center for Rehabilitation and Healthcare 2Health News:Advanced Heart Failure Recovery Program comes to Deptford Center for Rehabilitation and Healthcare 3Health News:2014 Best Friday Deals Revealed by Top10InAction 2
... representatives and surgical ... Colo., Sept. 6 Syndicom, the premier developer,of ... had,finalized a one-year agreement with DePuy Spine, a ... agreed to provide software and,consulting services to develop ...
... Cutters scores, more than $70,000 in funds and diapers for the state,s ... ... NORTH HAVEN, Conn., Sept. 6 BlueCare(R) Family Plan,the Medicaid (HUSKY) ... the completion of its two-month public,awareness campaign for the New Haven Diaper ...
... now been thoroughly screened in the hunt for the ... confirms previous hypotheses and turn the spotlight on entirely ... prestigious New England Journal of Medicine. , Rheumatoid arthritis ... one per cent of the population. Its causes are ...
... joint study by UCLA and the Rand Corp. shows that ... not consistently in that parents custody. , Researchers found that ... not in the HIV-infected parents custody at any time. , ... nationally representative sample of people in care for HIV infection ...
... 1 million Medicare patients develop pressure ulcers costing the ... system more than $10 billion ... 10th Annual International Pressure Ulcer Prevalence Survey (IPUPS) were,released by ... a leading provider of medical technology for hospitals and other,care ...
... ABAX ), a medical products company manufacturing point-of-care,blood ... will present at the CL King & Associates, Inc. ... 11:45 a.m. Eastern Time,at the Omni Berkshire Place Hotel ... develops, manufactures and markets portable blood analysis,systems for use ...
Cached Medicine News:Health News:Syndicom to Launch Online Community for DePuy Spine 2Health News:BlueCare(R) Family Plan, a HUSKY Health Plan from Anthem Blue Cross and Blue Shield in Connecticut, Raises Awareness, Funds and Diapers for New Haven Diaper Bank 2Health News:BlueCare(R) Family Plan, a HUSKY Health Plan from Anthem Blue Cross and Blue Shield in Connecticut, Raises Awareness, Funds and Diapers for New Haven Diaper Bank 3Health News:The genes involved in rheumatoid arthritis identified 2Health News:UCLA/RAND study shows that many children of HIV-positive parents are not in their custody 2Health News:Hospitals Could Improve Outcomes for Patients and Save Millions According to Hill-Rom 10th Annual Pressure Ulcer Survey 2Health News:Hospitals Could Improve Outcomes for Patients and Save Millions According to Hill-Rom 10th Annual Pressure Ulcer Survey 3Health News:Hospitals Could Improve Outcomes for Patients and Save Millions According to Hill-Rom 10th Annual Pressure Ulcer Survey 4
(Date:11/26/2014)... 2014  Avanir Pharmaceuticals, Inc. (NASDAQ: AVNR ... Drug Administration (FDA) has issued a Complete Response ... AVP-825. AVP-825 is an investigational drug-device combination product ... a novel Breath Powered delivery technology. ... with the preliminary feedback announced on November 7, ...
(Date:11/26/2014)... Nov. 26, 2014  BioScrip ® , Inc. (NASDAQ: ... and Chief Executive Officer, will present at the Bank of America ... , , Date: , , , Wednesday, December 3, 2014 ... EST , , , , Location: , , , Boca ... About BioScrip, Inc. BioScrip, Inc. is a ...
(Date:11/26/2014)... Calif. , Nov. 26, 2014  Aridis ... to produce novel therapies for infectious diseases, announced ... M.D., an internationally recognized key opinion leader in ... Company,s scientific advisory board. Founder and ... stated, "We believe Dr. Opal,s extensive experience investigating ...
Breaking Medicine Technology:Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 2Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 3Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 4Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3
... 5, 2012  First Choice Services has taken over operation of ... Virginia University School of Medicine. "We are ... tool that is so vital in the fight against prescription ... of First Choice Services, said. "We want to build on ...
... US today announced that the U. S. District Court ... a Synvisc-One ® (hylan G-F 20) ... for a restricted launch of Seikagaku,s product prior to ... from selling their product below the current average sales ...
Cached Medicine Technology:West Virginia's Prescription Drug Abuse Helpline Receives New Management 2Sanofi Announces Court Ruling Granting Preliminary Injunction Against Synvisc-OneĀ® Competitor Product 2
Midstream Catch Kits...
... BVI 6100 is a handheld, noninvasive ultrasound ... easy to operate, so any staff member ... view ultrasound images from exams and print ... and reimbursement, just log on to ScanPoint®, ...
... Collagen Implant, the world's leading bulking therapy, ... the treatment of Stress Urinary Incontinence (SUI). ... urethral tissue to aid coaptation in a ... own structure, Contigen Bard Collagen Implant forms ...
... Positionable Penile Prosthesis,The AMS ... is made of cobalt-chrome ... strength that gives patients ... ease of positioning, cosmetic ...
Medicine Products: