Navigation Links
New class of compounds discovered for potential Alzheimer's disease drug
Date:8/10/2009

PHILADELPHIA A new class of molecules capable of blocking the formation of specific protein clumps that are believed to contribute to Alzheimer's disease pathology has been discovered by researchers at the University of Pennsylvania School of Medicine. By assaying close to 300,000 compounds, they have identified drug-like inhibitors of AD tau protein clumping, as reported in the journal Biochemistry.

Co-authors Alex Crowe, Research Specialist; Kurt R. Brunden, PhD, Director of Drug Discovery at Penn's Center for Neurodegenerative Disease Research (CNDR); Virginia M.-Y. Lee, PhD, and John Q. Trojanowski, MD, PhD, CNDR Co-Directors, and colleagues conducted the screen to find small molecules that prevent the formation of the tau protein fibrils. These fibrils, a hallmark pathological feature of AD, have been a holy grail for investigators hoping to better treat AD and related neurodegenerative diseases.

Tau fibrils accumulate as insoluble deposits in brain nerve cells of patients with a host of debilitating neurodegenerative diseases, the most prevalent of which is AD. Since these tau aggregates are found in several neurodegenerative disorders and are thought to contribute to disease pathology, it is hoped that drugs that prevent these deposits might prove to be effective therapeutic agents for AD and related disorders. This is the largest drug screen completed to date using the compound repository housed at the National Institutes of Health (NIH) Chemical Genomics Center.

Small molecules that prevent or reverse tau clumping might have therapeutic value, explains Brunden. Examples of such compounds have been described previously but nearly all have properties, such as chemical reactivity, poor absorption by the gut, or poor brain penetration, that render them unsuitable as drug candidates.

The test-tube-based assay used to screen the large NIH library was designed by Dr. Lee to see if each compound could block fibr
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Allscripts Notified of Purported Class Action Lawsuit
2. Chindex International, Inc. Launches World-Class Cancer Treatment Center
3. Hagens Berman Sobol Shapiro: Vytorin and Zetia Makers Settle Class-Action Suit With Proposed $41.5 Million
4. Class Action Notice for Minnesota Light Cigarette Litigation From Lommen, Abdo, Cole, King & Stageberg, P.A.
5. More Than One in Five 12 to 17-Year-Olds Have Trouble Seeing in Class
6. Gym Class Injuries Up 150 Percent
7. New national study finds increase in P.E. class-related injuries
8. Post-Recession Incomes Will Be Hit Hard by Health Care Spending for Middle Class Working Families, PENN Analysis Shows
9. American Academy of Dermatology Commends Reclassification of Tanning Beds as Carcinogenic
10. Birdies for Breast Cancer Announces Fifth Annual Charity Golf Classic Hosted by Top Womens Golfer, Cristie Kerr
11. The CLASS Act: Retirement In-Security
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New class of compounds discovered for potential Alzheimer's disease drug
(Date:1/22/2015)... 2015 The Incredible Bulk is a revolutionary ... increase lean muscle by up to 30lbs in less than ... of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... step-by-step, scientific diet formula that allows the body to pack ...
(Date:1/22/2015)... 23, 2015 AngelWeddingDress, the premier women’s ... maternity wedding dresses. View website of AngelWeddingDress.com ... for maternity wedding dresses online for a bridal party. ... high quality for them. Its maternity wedding dresses are ...
(Date:1/22/2015)... 2015 A new white paper by ... person-centeredness in the long-term care environment as well as ... continuum. The paper, “The Power of Person-Centeredness in Long-Term ... practices of the patient, resident and family experience in ...
(Date:1/22/2015)... 22, 2015 For over 20 years, Dr. David ... and Vista area has treated just about every type of ... circumstances. And for those same twenty-plus years, the team at ... those injuries with the best possible doctor. With the ...
(Date:1/22/2015)... NY (PRWEB) January 22, 2015 ... of Sports Medicine flagship journal Medicine & Science ... L-Citrulline before exercise may help reduce gastrointestinal (GI) ... 1 , Participants in the double-blind, placebo-controlled ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3
... Biopure Corporation (Nasdaq: BPUR ) announced today ... 11 of the United States Bankruptcy Code in the United States ... to manage and operate its businesses and assets during the pendency ... Court. , , In connection with ...
... , , , SAN FRANCISCO, ... injuries and property damage from drywall imported from China is the ... July 28, 2009 at the Mission Bay Conference Center at the ... webcast. , , The conference producer, ...
... , , DETROIT, July 16 ... looking for alternative options to decrease spending without losing employee coverage. ... coverage for their employees and lower their costs by as much ... , , An HRA ...
... out, genes alone aren,t destiny, study finds , THURSDAY, ... behavior problems are influenced by both genetic and environmental ... research on genetic and environmental influences on behavior was ... professor of psychiatry, psychology, and human and molecular genetics ...
... higher risk of heart attack, stroke, agency says, , ... and Drug Administration has begun a safety review of ... increased risk of heart attack, abnormal heart rhythm, heart ... results from the Evaluating the Clinical Effectiveness and Long-Term ...
... NEW YORK and LOS ANGELES, July 16 "Back for a ... , with Benjamin Bratt starring as an ,extreme interventionist, a character ... What,s encouraging about The Cleaner is the exposure the ... With more than 23 million Americans misusing drugs these days, there,s ...
Cached Medicine News:Health News:Chinese Drywall Litigation & Insurance Conference July 28 in San Francisco 2Health News:How To Reduce Cost Without Sacrificing Your Health Coverage 2Health News:Teen Behaviors Stem From Genetics, Environment 2Health News:FDA Investigating Safety of Asthma Drug Xolair 2Health News:Coming Clean About The Cleaner - Phoenix House's Chief Clinical Officer David Deitch on Intervention, and the Recovery Process That Follows 2Health News:Coming Clean About The Cleaner - Phoenix House's Chief Clinical Officer David Deitch on Intervention, and the Recovery Process That Follows 3
(Date:1/23/2015)... For the pharmaceutical industry, marketplace success is tied to ... importance of the managed markets function - which is pharma,s ... payer formularies and provider networks play an increasingly large role ... time, managed markets leaders must continually identify the optimal resource ...
(Date:1/23/2015)... , Jan. 23, 2015 Research and Markets ( ... Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and ... Video communication has been the topic of fascination since ... United States and the Soviet Russia. Earlier even ...
(Date:1/23/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ) ... Market (Indwelling or Foley Catheters, Intermittent Catheters and Male ... Share, Growth, Trends and Forecast 2014 - 2020" ... present, the global market for urinary catheters is experiencing ...
Breaking Medicine Technology:As Payer Influence Rises, Pharmaceutical Companies work to Optimize the Managed Markets Function 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3
Scoville-Greenwood bayonet forceps...
Scleral blades designed for trabeculectomy and groove type incisions, scleral standard USA size....
OKN drum...
Sterile squares of textured nylon foil for repair of the floor of the orbit....
Medicine Products: