Navigation Links
New class of compounds discovered for potential Alzheimer's disease drug
Date:8/10/2009

PHILADELPHIA A new class of molecules capable of blocking the formation of specific protein clumps that are believed to contribute to Alzheimer's disease pathology has been discovered by researchers at the University of Pennsylvania School of Medicine. By assaying close to 300,000 compounds, they have identified drug-like inhibitors of AD tau protein clumping, as reported in the journal Biochemistry.

Co-authors Alex Crowe, Research Specialist; Kurt R. Brunden, PhD, Director of Drug Discovery at Penn's Center for Neurodegenerative Disease Research (CNDR); Virginia M.-Y. Lee, PhD, and John Q. Trojanowski, MD, PhD, CNDR Co-Directors, and colleagues conducted the screen to find small molecules that prevent the formation of the tau protein fibrils. These fibrils, a hallmark pathological feature of AD, have been a holy grail for investigators hoping to better treat AD and related neurodegenerative diseases.

Tau fibrils accumulate as insoluble deposits in brain nerve cells of patients with a host of debilitating neurodegenerative diseases, the most prevalent of which is AD. Since these tau aggregates are found in several neurodegenerative disorders and are thought to contribute to disease pathology, it is hoped that drugs that prevent these deposits might prove to be effective therapeutic agents for AD and related disorders. This is the largest drug screen completed to date using the compound repository housed at the National Institutes of Health (NIH) Chemical Genomics Center.

Small molecules that prevent or reverse tau clumping might have therapeutic value, explains Brunden. Examples of such compounds have been described previously but nearly all have properties, such as chemical reactivity, poor absorption by the gut, or poor brain penetration, that render them unsuitable as drug candidates.

The test-tube-based assay used to screen the large NIH library was designed by Dr. Lee to see if each compound could block fibr
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Allscripts Notified of Purported Class Action Lawsuit
2. Chindex International, Inc. Launches World-Class Cancer Treatment Center
3. Hagens Berman Sobol Shapiro: Vytorin and Zetia Makers Settle Class-Action Suit With Proposed $41.5 Million
4. Class Action Notice for Minnesota Light Cigarette Litigation From Lommen, Abdo, Cole, King & Stageberg, P.A.
5. More Than One in Five 12 to 17-Year-Olds Have Trouble Seeing in Class
6. Gym Class Injuries Up 150 Percent
7. New national study finds increase in P.E. class-related injuries
8. Post-Recession Incomes Will Be Hit Hard by Health Care Spending for Middle Class Working Families, PENN Analysis Shows
9. American Academy of Dermatology Commends Reclassification of Tanning Beds as Carcinogenic
10. Birdies for Breast Cancer Announces Fifth Annual Charity Golf Classic Hosted by Top Womens Golfer, Cristie Kerr
11. The CLASS Act: Retirement In-Security
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New class of compounds discovered for potential Alzheimer's disease drug
(Date:5/24/2015)... May 24, 2015 ProPin is a ... Cut Pro X. Utilize ProPin to pin point locations on ... scene. , ProPin allows users to choose from 30 ... FCPX. With on-screen controls, video editors can easily manipulate ProPin ... pin and mark with absolute ease. , Using ProPin is easy, ...
(Date:5/23/2015)... 2015 On Saturday, May 23, 2015, over ... for Branches Florida City exactly five years to the day ... 2010. , A large fire tore through the Branches United ... 2010 in the middle of the night as neighbors, staff ... declared arson even though it is suspected that the fire ...
(Date:5/23/2015)... 23, 2015 On May 16, the team ... event was a 5k mud obstacle run that raised funds ... million people worldwide, and the reason we participated was to ... Davis, owner of Farrell’s eXtreme Bodyshaping. “One-hundred percent of the ... , The event was not only attended by eXtreme Bodyshaping ...
(Date:5/23/2015)... 23, 2015 Injury lawyer Steven H. Heisler ... passed by the Maryland legislature but which has not been ... Assembly passed HB 449 with overwhelming bipartisan support ... signed it into law. This bill ensures that fracking is ... that demonstrates the danger of fracking to our water supplies ...
(Date:5/22/2015)... East Liverpool, OH (PRWEB) May 22, 2015 ... today announced that Kyle Johnson, the health system’s Chief ... pursue other interests. Johnson has served as the company ... announced Wesley West will be joining the health system ... operations on an interim basis, while the Board of ...
Breaking Medicine News(10 mins):Health News:Developers at Pixel Film Studios Release ProPin for Final Cut Pro X. 2Health News:Five Years After Fire, Branches Rebuilds Playground 2Health News:Farrell’s eXtreme Bodyshaping Team Runs through the Muck for MS 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3Health News:River Valley Health Partners Announces CFO Transition, Appointment of Interim CFO 2
... are recruited annually to participate in clinical trials according to ... be compensated for their participation. ... and expenses; not as compensation for potential risks related to ... that volunteers have a very different view of clinical trial ...
... a response to pressure from federal regulators to crack down ... News) -- The makers of 24 different prescription painkillers on ... of these opioid drugs. , The pharmaceutical companies have ... to find a way to stop the hundreds of fatal ...
... drugs known as statins are among the most prescribed ... researchers at Fred Hutchinson Cancer Research Center indicates that ... of the most serious complications of the life-saving cancer ... in the Nov. 4 first edition of the journal ...
... , MADISON, Wis., Dec. 4 ... Department of Health Services needed to get more information to more ... (Nasdaq: SOFO ), the recognized market leader for rich ... Matt Duffy from the Wisconsin Department of Health Services, will share ...
... , , PARAMUS, N.J., Dec. 4 ... Watches and Brown & Co. Jewelers, Atlanta, Georgia, shared in ... Open quarterfinalist Melanie Oudin for her stellar performance in the ... since 1999. , (Photo: http://www.newscom.com/cgi-bin/prnh/20091204/NY21184 ) , ...
... Dec. 4, 2009 New findings by UT Southwestern ... autoimmune disorders might also help slow the destruction of ... 1) diabetes. In type 1 diabetes, formerly ... beta cells, which produce insulin, are destroyed by an ...
Cached Medicine News:Health News:Human guinea pigs wary of high-paying medical trials 2Health News:Makers of Powerful Painkillers Present Safety Plans 2Health News:Cholesterol-lowering drugs also may protect stem cell transplant patients from GVHD 2Health News:Live Webinar: Pandemic + Recession = Webcasting: Cost-Effective Streaming for Public Health Communications 2Health News:Live Webinar: Pandemic + Recession = Webcasting: Cost-Effective Streaming for Public Health Communications 3Health News:FDA-approved drug may slow beta cell destruction in type 1 diabetes patients 2
(Date:5/22/2015)... Richmond Pharmacology is a ... a worldwide reputation for excellence in clinical trials. ... peer reviewed medical journals. Its officers are engaged ... discussions about rules for transparency and publication of ... , Clinical research is conducted worldwide, ...
(Date:5/22/2015)...  China Nepstar Chain Drugstore Ltd. (NYSE: NPD ) ... in China based on the ... of Mr. Fuxiang Zhang as the Company,s ... Rebecca Yingnan Zhang has been appointed as ... effective immediately. Meanwhile, Ms. Zhang resigned from the position ...
(Date:5/21/2015)... May 21, 2015  When Ryan Rendino ... side of his neck, he figured it ... couple weeks off from weight lifting. ...                               A series of ... referred to Michel Kliot, MD , ...
Breaking Medicine Technology:China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 3Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 3Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 4
... provides specialty-specific EMR solutions to physicians in ... physician practices for so long, we know ... of every organization. Therefore, Misys EMR was ... as orders management and document imaging can ...
... OfficeMate is the industry's most ... management software available. In fact, OfficeMate ... management software today with one out ... using OfficeMate. OfficeMate takes care of ...
... Practice management software for ... a true multi-tasking, multi-office practice ... in database technology- Winx Pro ... will assist you in effectively ...
Easy-to-use and afforable practice management software. For more details, please contact First Insight....
Medicine Products: