Navigation Links
New class of cancer drugs could work in colon cancers with genetic mutation, U-M study finds
Date:4/25/2011

ANN ARBOR, Mich. A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.

Working in cell lines from colorectal cancer patients, researchers found that a new class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.

About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation.

"This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, M.D., Ph.D., a hematology/oncology fellow at the U-M Medical School.

The study, which was published in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.

Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.

Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is n
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Research Warns of Overuse of Powerful Class of Antibiotics
2. Social class makes no difference to water contamination risk
3. Classroom Environment May Affect Kids Mental Health
4. Study: Negative classroom environment adversely affects childrens mental health
5. Scripps Research and MIT scientists discover class of potent anti-cancer compounds
6. College Kids Often Feel Guilty About Texting in Class: Survey
7. Lung societies unveil new international classification of lung adenocarcinoma
8. New classification of sphincter of Oddi dysfunction
9. Social class and changes in mortality from liver cirrhosis over the 20th Century
10. Emerging drug class may enhance red blood cell production in anemic patients
11. How We Die, award-winning classic, updated for 2010
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New class of cancer drugs could work in colon cancers with genetic mutation, U-M study finds 
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue Cross) wants ... “Live Fearless.” , The “Faces of Fearless” campaign ... how they or someone they know has faced a challenge, ... moment. By telling these types of stories through livefearlessmn.com, participants ...
(Date:1/22/2015)... The federal court overseeing thousands of vaginal ... Southern District of West Virginia has upheld a $2 million ... bellwether trial. In an Order dated January 21st, the Court ... that C.R. Bard had not proven a miscarriage of justice. ...
(Date:1/22/2015)... TX (PRWEB) January 22, 2015 A ... issue of experience and person-centeredness in the long-term care ... towards action across the continuum. The paper, “The Power ... Continuum,” engages perspectives and practices of the patient, resident ...
(Date:1/22/2015)... 2015 Autocarinsurancebest.com has released a new blog ... auto insurance policy . , Auto insurance quotes help ... is no longer necessary to call an agent or visit ... online on a single website: http://autocarinsurancebest.com/ . , Every ...
(Date:1/22/2015)... 2015 Carinsurancesavings.biz has released a new blog ... dismemberment insurance . , Purchasing an accidental death and ... advantageous. This type of rider provides benefits if the insured ... considered a lesser form of life insurance. , AD&D ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2
... Genesis,Pharmaceuticals Enterprises, Inc. (OTC Bulletin Board: GNPH) (the ... in the People,s,Republic of China, today announced that ... ("Jiangbo"). , The Company ... the,State of Florida that the Certificate of Amendment ...
... April 23 /PRNewswire-FirstCall/ - Labopharm Inc. (TSX: DDS; NASDAQ: ... times of its first quarter fiscal 2009 results conference ... CallOn Thursday, May 7 at 8:30 a.m. (ET) Labopharm ... quarter 2009 financial results. Labopharm will report its first ...
... In-Line With or Exceed ExpectationsDENVER, April 23 ... AIRM ), the largest air medical transportation ... first quarter 2009 earnings exceed expectations. ... patient transports in March, improved reimbursement for ...
... establishing day to honor momGROVE CITY, Ohio, April 23 ... Fraternal Order of Eagles ( http://www.FOE.com ... grandmother understands the juggling act that mothers carry out everyday. ... is an Eagles tradition. The second Sunday in May was ...
... vision care practice in San Diego, California is opening its virtual doors ... Weiss Vision Institute is using internet video and other advanced tools on ... improve their eyesight. , ... (Vocus) April 23, 2009 -- The Gordon ...
... its rebranded version 2.0 service: an innovative medical news search ... news in medical sources is found. Excellent new tool for medical ... ... (PRWEB) April 23, 2009 -- Newsguard today launched its rebranded version ...
Cached Medicine News:Health News:Genesis Pharmaceuticals Changes its Name to Jiangbo Pharmaceuticals, Inc. to Reflect its Brand Name 2Health News:Genesis Pharmaceuticals Changes its Name to Jiangbo Pharmaceuticals, Inc. to Reflect its Brand Name 3Health News:Labopharm announces details for first quarter results conference call and annual meeting 2Health News:Air Methods' Preliminary 1st Qtr. Results Exceed Expectations 2Health News:Air Methods' Preliminary 1st Qtr. Results Exceed Expectations 3Health News:Fraternal Order of Eagles Grand Madam President Celebrates Mother's Day 2Health News:Gordon Binder & Weiss Vision Institute in San Diego Launches Innovative New Website 2Health News:Gordon Binder & Weiss Vision Institute in San Diego Launches Innovative New Website 3Health News:Gordon Binder & Weiss Vision Institute in San Diego Launches Innovative New Website 4Health News:Innovative Search Engine for Medical News, Newsguard 2.0, Launched 2
(Date:1/23/2015)... 23, 2015  MedScope ( www.medscope.org ), the leading provider ... 2015 Connected World magazine Connected World Award ... that can be used anywhere, anytime. The nomination was ... In nominating MedScope, Landon Garner , Director ...
(Date:1/23/2015)... 2015  HyGreen, Inc., a leader in hand hygiene monitoring, ... Medical, a subsidiary of Ascendis Health Limited, in ... year, hundreds of millions of patients around the world ... transmitted from patient to patient via the unwashed hands ...
(Date:1/23/2015)... CAPE TOWN, South Africa , Jan. 23, 2015 ... and distributor of personal protective equipment for all forms ... include the flagship Leatt-Brace® neck brace, announced today that ... minicross racing federation, now requires all riders to wear ...
Breaking Medicine Technology:MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2HyGreen Partners with RCA Medical in Johannesburg, South Africa 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3
... Slimline multi-use catheters are designed using ... with the following benefits:, ,Working ... ,In procedures where the multi-use catheter ... creates stable contact to the skin.,NOTE: ...
... Slimline single-use pH catheters are ... cross-contamination and allow greater patient comfort ... ,Medtronic pH measurement systems have been ... that allow an accurate room-temperature calibration. ...
The WaveMax is one of the most flexible stainless steel stents due to its unique wave design and has the lowest effective profile, accommodating a 6F sheath up to 7 mm....
... Explore the world of online ... live, intralaboratory control information and peer ... ,Quantrol Online introduces a revolutionary internet ... control information. Why rely on traditional ...
Medicine Products: