Navigation Links
New class of RNA molecules may be important in human cancer
Date:9/11/2007

COLUMBUS, Ohio Research here shows that an obscure form of RNA, part of the protein-making machinery in all cells, might play an important role in human cancer.

These ultraconserved non-coding RNAs (UCRs) have been considered junk by some researchers, but a new report in the September issue of the journal Cancer Cell indicates that this may not be the case.

The study found that UCRs, like classic oncogenes, can contribute to cancer development. It also showed that the type and amount of UCRs is different in cancer cells for each of three cancer types, suggesting that these molecules might prove useful in diagnosing the disease and in determining a patients prognosis and perhaps even treatment.

Along with oncogenes, tumor suppressor genes and microRNA, this seems to be another family of genes that plays an important role in cancer, says principal investigator Carlo M. Croce, professor and chair of the department of molecular virology, immunology and medical genetics at Ohio State University and a researcher with Ohio States Comprehensive Cancer Center.

Our next step is to learn how they work and if they are good targets for drug therapy.

The new study involved a number of experiments. One showed that some genes that encode for UCRs are located in chromosome regions that are often lost or damaged in cancer cells. This suggests that certain UCRs might be genetic markers for cancer susceptibility.

In another experiment, Croce and his colleagues measured the activity of UCR genes in human chronic lymphocytic leukemia, and colorectal and liver cancer. Overall, they examined 133 tumor samples and 40 samples of corresponding normal tissue.

Each cancer type showed a specific activity pattern for certain UCRs, suggesting that these molecules might one day help distinguish between different types of human cancers.

Moreover, the investigators identified a signature of five UCRs able to differentiate a slowly progressing form of chronic lymphocytic leukemia and a form that progresses quickly and aggressively.

At the same time, they discovered that some of these UCRs might be regulated by microRNAs. This finding was particularly intriguing because it suggests a totally new regulatory mechanism that involves noncoding RNAs, Croce says.

Finally, this study showed that artificially lowering the level of one UCR in colon cancer cells caused many of them to die, reducing their spread by almost half and showing that UCRs can serve as oncogenes.

Overall, our findings indicate that these molecules are involved in cancer, Croce says. But we need to learn if they are also involved in other diseases such as Alzheimers and heart disease.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. “ Economy Class Syndrome
2. Latest Tumor Classification More Informative
3. Ultrasound may mean end to classic stethoscope
4. Self-Applied Acupressure May Reduce Sleepiness And Increase Alertness During Class Hours
5. Madhya Pradesh Cops to attend Yoga classes to reduce stress and weight
6. Sunflowers Could Hold the Key to New Class of AIDS Drugs
7. Campaigners Say No To Cannabis Reclassification
8. Kolkata To Get World-Class Cancer Hospital Soon
9. Peer Rejection Leads To Reduced Participation In Classroom Activities
10. East London Receives World Class New Private Hospital Facility
11. Welcome to ‘Stand Only’ Classrooms That Exercise The Brain And The Bod!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... innovative inhaled drugs, announced today that it was added ... reconstituted its comprehensive set of U.S. and global ... is an important milestone for Pulmatrix," said Chief Executive ... awareness of our progress in developing drugs for crucial ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
Breaking Medicine Technology: