Navigation Links
New class of RNA molecules may be important in human cancer
Date:9/11/2007

COLUMBUS, Ohio Research here shows that an obscure form of RNA, part of the protein-making machinery in all cells, might play an important role in human cancer.

These ultraconserved non-coding RNAs (UCRs) have been considered junk by some researchers, but a new report in the September issue of the journal Cancer Cell indicates that this may not be the case.

The study found that UCRs, like classic oncogenes, can contribute to cancer development. It also showed that the type and amount of UCRs is different in cancer cells for each of three cancer types, suggesting that these molecules might prove useful in diagnosing the disease and in determining a patients prognosis and perhaps even treatment.

Along with oncogenes, tumor suppressor genes and microRNA, this seems to be another family of genes that plays an important role in cancer, says principal investigator Carlo M. Croce, professor and chair of the department of molecular virology, immunology and medical genetics at Ohio State University and a researcher with Ohio States Comprehensive Cancer Center.

Our next step is to learn how they work and if they are good targets for drug therapy.

The new study involved a number of experiments. One showed that some genes that encode for UCRs are located in chromosome regions that are often lost or damaged in cancer cells. This suggests that certain UCRs might be genetic markers for cancer susceptibility.

In another experiment, Croce and his colleagues measured the activity of UCR genes in human chronic lymphocytic leukemia, and colorectal and liver cancer. Overall, they examined 133 tumor samples and 40 samples of corresponding normal tissue.

Each cancer type showed a specific activity pattern for certain UCRs, suggesting that these molecules might one day help distinguish between different types of human cancers.

Moreover, the investigators identified a signature of five UCRs able to differentiate a slowly progressing form of chronic lymphocytic leukemia and a form that progresses quickly and aggressively.

At the same time, they discovered that some of these UCRs might be regulated by microRNAs. This finding was particularly intriguing because it suggests a totally new regulatory mechanism that involves noncoding RNAs, Croce says.

Finally, this study showed that artificially lowering the level of one UCR in colon cancer cells caused many of them to die, reducing their spread by almost half and showing that UCRs can serve as oncogenes.

Overall, our findings indicate that these molecules are involved in cancer, Croce says. But we need to learn if they are also involved in other diseases such as Alzheimers and heart disease.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. “ Economy Class Syndrome
2. Latest Tumor Classification More Informative
3. Ultrasound may mean end to classic stethoscope
4. Self-Applied Acupressure May Reduce Sleepiness And Increase Alertness During Class Hours
5. Madhya Pradesh Cops to attend Yoga classes to reduce stress and weight
6. Sunflowers Could Hold the Key to New Class of AIDS Drugs
7. Campaigners Say No To Cannabis Reclassification
8. Kolkata To Get World-Class Cancer Hospital Soon
9. Peer Rejection Leads To Reduced Participation In Classroom Activities
10. East London Receives World Class New Private Hospital Facility
11. Welcome to ‘Stand Only’ Classrooms That Exercise The Brain And The Bod!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson ... offers insurance and financial preparation services, is providing an update on a charitable ... , Rock City Rescue is a locally recognized nonprofit that provides shelter and ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The American Board ... become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon ... beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon ...
(Date:10/13/2017)... (PRWEB) , ... October 13, ... ... School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, ... professionals on guideline updates for the primary prevention of cardiovascular diseases during ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and Company ... results for the third quarter of 2017 on Tuesday, ... call on that day with the investment community and ... The conference call will begin at 9 a.m. ... access a live webcast of the conference call through ...
(Date:10/2/2017)... Oct. 2, 2017 Halo Labs announces the European launch ... called the HORIZON at MIBio 2017 in Cambridge, U.K ... visible particulate matter in biopharmaceutical samples with unprecedented speed and sensitivity ... novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
Breaking Medicine Technology: