Navigation Links
New chemo cocktail blocks breast cancer like a strong fence
Date:10/6/2009

CHICAGO --- Think of a protective fence that blocks the neighbor's dog from charging into your backyard. The body, too, has fences -- physical and biochemical barriers that keep cells in their place.

When breast cancer spreads or metastasizes, it crashes through the body's protective fences. The disease becomes fatal when it travels outside the mammary ducts, enters the bloodstream and spreads to the bones, liver or brain. Currently, there are only drugs that try to stem the uncontrolled division of cancer cells within the ducts. Until now, no drugs specifically targeted the invasion and spread of breast cancer to the organs.

A researcher from Northwestern University Feinberg School of Medicine has found a way to strengthen the breast's "fence" to prevent cancer from metastasizing. Researcher Seth Corey, M.D., has discovered that when a drug normally used to treat leukemia is added to a commonly used breast cancer drug, the potent new chemotherapy cocktail helps prevent breast cancer cells from invading.

"This is an entirely new way of targeting a cancer cell," said Corey, the Sharon B. Murphy-Steven T. Rosen Research Professor of Cancer Biology and Chemotherapy at the Feinberg School and director of the pediatric oncology program at the Robert H. Lurie Comprehensive Cancer Program of Northwestern University.

Working in the lab with women's breast cancer cells, Corey found that when the leukemia drug dasatinib is combined with the breast cancer drug doxorubicin, the potent mix inhibits breast cancer cell invasion by half. Corey is the principal investigator of the study, which recently was reported in the British Journal of Cancer.

Dasatinib targets an enzyme called the Src kinase, which is believed to play a key role in breast cancer invasion and metastases.

"Perhaps this drug could be given to prevent invasion from happening in the first place," said Corey, who also is a pediatric oncologist at Children's Memorial Hospital. "This might keep the disease in check and prevent it from progressing."


'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. Results Reported for Exploratory Phase 2 Study of Nexavar in Combination With Chemotherapeutic Agent Paclitaxel for Treatment of Advanced Breast Cancer
2. Scientists Discover How Chemo Can Make Women Infertile
3. UCI researchers create new strategy for highly selective chemotherapy delivery
4. UCI researchers create new strategy for highly-selective chemotherapy delivery
5. Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
6. After-Effects of Chemotherapy May Include Memory Problems
7. Nexavar in Combination With Chemotherapy Demonstrates 74 Percent Improvement in Progression-Free Survival in Patients With Advanced Breast Cancer in Phase 2 Study
8. New Chemo Regimen May Benefit Ovarian Cancer Patients
9. Chemobrain -- the flip side of surviving cancer
10. Yeast unravels effects of chemotherapy drugs
11. Chemotherapy Linked to Sleep-Wake Cycle Disruptions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... PITTSBURGH, Pa. (PRWEB) , ... October 13, 2017 , ... ... the dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a ... access to medication in darkness or restricted lighting. As such, it eliminates the need ...
(Date:10/13/2017)... Las Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... of 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum ... CBD dose required and providing a CBD form that can be easily incorporated into ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest ... Senators Bill Cassidy (R-LA) and Lindsey ... notes that the medical device industry is in an ... device tax, the 2.3% excise tax on medical device ... they also want covered patients, increased visits and hospital ...
Breaking Medicine Technology: