Navigation Links
New chemo cocktail blocks breast cancer like a strong fence
Date:10/6/2009

CHICAGO --- Think of a protective fence that blocks the neighbor's dog from charging into your backyard. The body, too, has fences -- physical and biochemical barriers that keep cells in their place.

When breast cancer spreads or metastasizes, it crashes through the body's protective fences. The disease becomes fatal when it travels outside the mammary ducts, enters the bloodstream and spreads to the bones, liver or brain. Currently, there are only drugs that try to stem the uncontrolled division of cancer cells within the ducts. Until now, no drugs specifically targeted the invasion and spread of breast cancer to the organs.

A researcher from Northwestern University Feinberg School of Medicine has found a way to strengthen the breast's "fence" to prevent cancer from metastasizing. Researcher Seth Corey, M.D., has discovered that when a drug normally used to treat leukemia is added to a commonly used breast cancer drug, the potent new chemotherapy cocktail helps prevent breast cancer cells from invading.

"This is an entirely new way of targeting a cancer cell," said Corey, the Sharon B. Murphy-Steven T. Rosen Research Professor of Cancer Biology and Chemotherapy at the Feinberg School and director of the pediatric oncology program at the Robert H. Lurie Comprehensive Cancer Program of Northwestern University.

Working in the lab with women's breast cancer cells, Corey found that when the leukemia drug dasatinib is combined with the breast cancer drug doxorubicin, the potent mix inhibits breast cancer cell invasion by half. Corey is the principal investigator of the study, which recently was reported in the British Journal of Cancer.

Dasatinib targets an enzyme called the Src kinase, which is believed to play a key role in breast cancer invasion and metastases.

"Perhaps this drug could be given to prevent invasion from happening in the first place," said Corey, who also is a pediatric oncologist at Children's Memorial Hospital. "This might keep the disease in check and prevent it from progressing."


'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. Results Reported for Exploratory Phase 2 Study of Nexavar in Combination With Chemotherapeutic Agent Paclitaxel for Treatment of Advanced Breast Cancer
2. Scientists Discover How Chemo Can Make Women Infertile
3. UCI researchers create new strategy for highly selective chemotherapy delivery
4. UCI researchers create new strategy for highly-selective chemotherapy delivery
5. Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
6. After-Effects of Chemotherapy May Include Memory Problems
7. Nexavar in Combination With Chemotherapy Demonstrates 74 Percent Improvement in Progression-Free Survival in Patients With Advanced Breast Cancer in Phase 2 Study
8. New Chemo Regimen May Benefit Ovarian Cancer Patients
9. Chemobrain -- the flip side of surviving cancer
10. Yeast unravels effects of chemotherapy drugs
11. Chemotherapy Linked to Sleep-Wake Cycle Disruptions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... Georgia (PRWEB) , ... June 24, 2016 , ... ... awards today at the Clinical Decision Making in Emergency Medicine conference in Ponte ... have authored journal articles published in Emergency Medicine Practice and Pediatric ...
(Date:6/24/2016)... ... 24, 2016 , ... Puradigm® & Innovative Solutions today announced ... and processing operations at its production facility, and opened its first two dispensaries ... manufacturer of a complete system of proactive air and surface purification solutions for ...
(Date:6/24/2016)... ... , ... National recruitment firm Slone Partners is pleased to announce ... experience, as Vice President of North American Capital Sales at HTG Molecular . ... sales team in the commercialization of the HTG EdgeSeq system and associated reagents in ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, ... stem (iPS) cells and other difficult to transfect cells, announces its launch of ... PluriQ™ G9™ Gene Editing System is a complete system for culturing and ...
(Date:6/24/2016)... ... June 24, 2016 , ... Finally, a bruise cream that ... dermaka cream can be incorporated into the post-surgical treatment plans of a variety of ... , dermaka cream is very effective for bruising and causes a rapid resolution of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
(Date:6/23/2016)... 23, 2016 The vast majority of dialysis ... facility.  Treatments are usually 3 times a week, with ... including travel time, equipment preparation and wait time.  This ... grueling for patients who are elderly and frail.  Many ... and rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
Breaking Medicine Technology: