Navigation Links
New chemical probe provides tool to investigate role of malignant brain tumor domains
Date:3/1/2013

CHAPEL HILL, N.C. In an article published as the cover story of the March 2013 issue of Nature Chemical Biology, Lindsey James, PhD, research assistant professor in the lab of Stephen Frye, Fred Eshelman Distinguished Professor in the UNC School of Pharmacy and member of the UNC Lineberger Comprehensive Cancer Center, announced the discovery of a chemical probe that can be used to investigate the L3MBTL3 methyl-lysine reader domain. The probe, named UNC1215, will provide researchers with a powerful tool to investigate the function of malignant brain tumor (MBT) domain proteins in biology and disease.

"Before this there were no known chemical probes for the more than 200 domains in the human genome that recognize methyl lysine. In that regard, it is a first in class compound. The goal is to use the chemical probe to understand the biology of the proteins that it targets," said Dr. James.

Chromatin regulatory pathways play a fundamental role in gene expression and disease development, especially in the case of cancer. While many chemical probes work through the inhibition of enzyme activity, L3MBTL3 functions as a mediator of protein-to-protein interactions, which have been historically difficult to target with small, drug-like molecules.The researchers found three to four further disease subtypes within TN tumors, with more than 75 percent of the tumors falling into the basal-like subtype. Further research is needed to identify the distinct biomarkers shared by the expanded subtypes of TN cancers. The ultimate goal will be to target the individual biomarkers of these subtypes and create therapies that target their individual biology, according to Dr. Perou.

"Many people believe that protein-protein interactions are difficult to target. Often they have a large surface area, so it is hard for small molecules to go in and intervene," said Dr. James.

Almost 40 percent of the genes that drive cancer can be mapped to d
'/>"/>

Contact: William Davis
william_davis@med.unc.edu
919-962-3405
University of North Carolina Health Care
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Foods Might Serve Up High Levels of Chemicals Found in Plastics
2. American Chemical Society podcast: New super-nutritious puffed rice for breakfast cereals, snacks
3. Plastics Chemical BPA Common in Preemie ICU: Study
4. Flame Retardant Chemicals Market growing at a CAGR of 6.9% & to reach $7,131.9 Million by 2017 - New Report by MarketsandMarkets
5. Chemicals in Cookware, Carpets May Raise Arthritis Risk in Women
6. Chemicals From Antibacterial Products Found in Minnesota Lakes
7. Test for hormone-disrupting chemicals gets global seal of approval
8. Could Chemical in Dishware Raise Your Risk for Kidney Stones?
9. 2013 economic outlook for global chemical industry
10. New American Chemical Society podcast: Leaves of carob tree fight food-poisoning bacteria
11. New treatment could combat deadly chemical agents
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New chemical probe provides tool to investigate role of malignant brain tumor domains
(Date:8/2/2015)... ... ... Molecular biologists in New South Wales say a protein linked to cell proliferation ... article on the new research. Click here to read it now. , ... samples from 42 patients with peritoneal mesothelioma and found a direct correlation with outcomes. ...
(Date:8/1/2015)... Angeles, CA (PRWEB) , ... August 01, 2015 , ... Have you ever wondered what ... up when you hear the word “Karma.” , Vedic tradition, which gave birth to ... Karma is one of the central concepts of this tradition. According to the wisdom of ...
(Date:8/1/2015)... ... August 01, 2015 , ... Brig and Lita Hart, icons of the network ... their Healthy Home mission with the HOPE Movement of EvolvHealth. In what has been ... companies have agreed to join their missions of purpose together to change the course ...
(Date:8/1/2015)... , ... August 01, 2015 , ... BeverlyD, owner and ... March4thforWellBeing foundation, making hers the very first small business donation to kick off the ... for over thirty years. Her legacy includes a complete line of raw, organic hair ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reputable source of authentic ... Grand Garden Arena. Fans of every genre of music will have an act they ... first day of the festival, the following artists will perform: Sam Smith, Coldplay, Kenny ...
Breaking Medicine News(10 mins):Health News:Scientists Link Protein Marker with Mesothelioma Prognosis in New Study, According to Surviving Mesothelioma 2Health News:Nithyananda Yoga Foundation to Conduct Global Webinar on Karma at No Charge on August 1st 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:March4thforWellBeing Foundation Kickoff 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3
... HealthDay Reporter , TUESDAY, Feb. 15 (HealthDay News) ... common than thought among high school athletes, especially among ... finds. "The risk is that we,re often dealing ... perfect their performance, and sometimes they overdo it," said ...
... The Department of Orthopaedic Surgery at NYU Langone Medical ... centers across the country to participate in the American ... independent, not-for-profit organization created to collect key joint replacement ... device performance and identify underperforming processes while providing information ...
... in reducing risk for acquiring HAIs , Study shows 64 percent ... for both ICU and general medical unit patients ... found a reduced risk of hospital-acquired infections (HAI) when using two ... and water. The study found a 64 percent decrease in the ...
... A new study led by an NYU School of Medicine ... Publication, International Journal of Obesity , challenges the idea ... of teenagers or what parents purchase for their children. Teens ... as adults, however they respond at a lower rate. The ...
... HealthDay Reporter , MONDAY, Feb. 14 (HealthDay News) -- Eating ... dying from heart disease, respiratory disease or any other cause ... report. Fiber has also been tied to a reduced ... the researchers added. In addition, fiber helps bowel movements and ...
... works in the "real world" may more effectively ... only on findings in clinical research settings, according ... Association,s cardiovascular disease prevention guidelines for women., First ... been primarily based on findings observed in clinical ...
Cached Medicine News:Health News:Stress Fractures Hitting High School Athletes 2Health News:Stress Fractures Hitting High School Athletes 3Health News:NYU Langone Department of Orthopaedic Surgery chosen to participate in joint replacement registry 2Health News:NYU Langone Department of Orthopaedic Surgery chosen to participate in joint replacement registry 3Health News:Using chlorhexidine gluconate baths to reduce hospital-acquired infections 2Health News:Calorie labeling has no effect on teenagers' or parents' food purchases 2Health News:Calorie labeling has no effect on teenagers' or parents' food purchases 3Health News:Diet High in Fiber Might Lengthen Your Life 2Health News:Diet High in Fiber Might Lengthen Your Life 3Health News:Updated heart disease prevention guidelines for women focus more on 'real-world' recommendations 2Health News:Updated heart disease prevention guidelines for women focus more on 'real-world' recommendations 3
(Date:7/31/2015)... 2015 According to a new ... (Bioimpedance Analyzers (BIA), Dual-Energy X-ray Absorptiometry (DEXA), Skinfold Calipers, ... Analysis & Forecast to 2019", published by MarketsandMarkets, the ... Million 2014 and is estimated to grow to $1,425.7 ... from 2014 to 2019. Browse 41 ...
(Date:7/30/2015)... July 30, 2015  ResMed (NYSE: ... a definitive agreement to acquire Curative Medical, ... and sleep-disordered breathing medical devices and accessories. ... in China, combined with ResMed,s global leadership in sleep and respiratory ... China suffering from sleep-disordered ...
(Date:7/30/2015)... 2015  EP Global Communications, Inc. (Public OTC: EPGL) announced ... the Company about discussing EPGL,s electronic contact lens ... August 3, 2015.  Novartis CEO Joe Jimenez ... coming electronic contact lens market could be worth ... several years.  Novartis partnered with Google in 2014 ...
Breaking Medicine Technology:Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3
... March 15, 2012 Reportlinker.com announces that ... in its catalogue: ... http://www.reportlinker.com/p0578259/Vaccines---Asia.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_and_Medication This market research report ... actual market situation, trends and future outlook ...
... March 14, 2012 Brainlab wins coveted ,red dot ... world submitted 4,515 designs altogether to the international product ... received the globally sought after red dot in product ... technology. This advanced surgical navigation system for the brain ...
Cached Medicine Technology:Vaccines - Asia 2Brainlab Curve Wins Coveted Red Dot Award: Product Design 2012 2Brainlab Curve Wins Coveted Red Dot Award: Product Design 2012 3
Portex® Blue Line® cuffed endotracheal tubes come in a wide selection of sizes, each with a standard 15 mm ISO connector., ,Portex® Blue Line® endotracheal tubes are recognized world...
Ruschelit® PVC. Magill tip - nasoral. X-ray opaque line. Graduated. Single use. Sterile...
Ruschelit® PVC. Murphy eye-nasoral. Black positioning ring. High volume/low pressure cuff. X-ray opaque line. Graduated. Single use....
Ruschelit® PVC. Siliconized. Stainless steel spiral reinforced. No cuff.Connector is permanently fixed into the tube. X-ray opaque. Graduated. Single use. Sterile...
Medicine Products: