Navigation Links
New candidate drug stops cancer cells, regenerates nerve cells
Date:6/21/2012

CINCINNATI Scientists have developed a small-molecule-inhibiting drug that in early laboratory cell tests stopped breast cancer cells from spreading and also promoted the growth of early nerve cells called neurites.

Researchers from Cincinnati Children's Hospital Medical Center report their findings online June 21 in Chemistry & Biology. The scientists named their lead drug candidate "Rhosin" and hope future testing shows it to be promising for the treatment of various cancers or nervous system damage.

The inhibitor overcomes a number of previous scientific challenges by precisely targeting a single component of a cell signaling protein complex called Rho GTPases. This complex regulates cell movement and growth throughout the body. Miscues in Rho GTPase processes are also widely implicated in human diseases, including various cancers and neurologic disorders.

"Although still years from clinical development, in principle Rhosin could be useful in therapy for many kinds of cancer or possibly neuron and spinal cord regeneration," said Yi Zheng, PhD, lead investigator and director of Experimental Hematology and Cancer Biology at Cincinnati Children's. "We've performed in silica (computerized) rational drug design, pharmacological characterization and cell tests in the laboratory, and we are now starting to work with mouse models."

Because the role of Rho GTPases in cellular processes and cancer formation is well established, researchers have spent years trying to identify safe and effective therapeutic targets for specific parts of the protein complex. In particular, scientists have focused on the center protein in the complex called RhoA, which is essential for the signaling function of the complex. In breast cancer for example, increased RhoA activity makes the cancer cells more invasive and causes them to spread, while a deficiency of RhoA suppresses cancer growth and progression.

Despite this knowledge, past
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel drug candidates offer new route to controlling inflammation
2. Presidential candidates should address childhood obesity and bullying, poll says
3. Parc at Piedmont - East Cobb to Host Candidate Forum for Primary Elections
4. Study Suggests Vaccine May Help Kids With Brain Cancer
5. New Stool Test Might Aid in Early Detection of Colon Cancer
6. Study reveals how cancer drug causes diabetic-like state
7. How a cancer drug leads to diabetes
8. You Survived Cancer: Now Pay Attention to Your Overall Health
9. New drug prevents spread of human prostate cancer cells
10. Eliminating the good cholesterol receptor may fight breast cancer
11. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... French physician and gastronome Anthelme Brillat-Savarin ... he uttered, “Tell me what you eat, and I ... cope with stress or sadness has often been attributed ... otherwise. Data collected from their Emotional Eating Test ... eating, but for different reasons. , Collecting data from ...
(Date:4/17/2015)... 2015 Riviera Magazine has ... of the Gallery of Cosmetic Surgery in Newport ... experts. The publication focused on his expertise in ... fat grafting, eyelid surgery, laser resurfacing and rhinoplasty. , ... has resulted in thousands of satisfied patients across ...
(Date:4/17/2015)... April 17, 2015 In Defense of ... following statement: “On Wednesday April 15th, the European Parliament ... a resolution recognizing the Armenian Genocide, “paying tribute, on ... the one-and-a-half million innocent Armenian victims who perished in ... extols the EU for this timely and needed recognition ...
(Date:4/17/2015)... At the end of February 2015, ... “Salute to the Oscars” in the Stardust Penthouse on ... the impressive Los Angeles skyline. These events honoring the ... LA’s leading producer of sustainable product placement in TV ... premier providers of eco-friendly and socially conscious products and ...
(Date:4/17/2015)... 2015 Scientists from the Icahn ... of U.S. and Venezuelan researchers, have discovered the ... among an isolated tribe of Yanomami Amerindians in ... in the Yanomami, previously unexposed to antibiotics or ... that of people living in industrialized countries, and ...
Breaking Medicine News(10 mins):Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 3Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 4Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 6Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3Health News:In Defense of Christians Condemns Armenian Genocide 2Health News:In Defense of Christians Condemns Armenian Genocide 3Health News:Choices Recovery Speaks with Dakota Hood of “The Hunger Games” about Addiction in Hollywood 2Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 2Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 3
... known is a silent killer because it often goes unnoticed. ... lead to a lot of complications such as heart attack, ... can be diagnosed by a very simple out patient examination ... inexpensive, but widely overlooked drugs may help many patients who ...
... Breast Cancer Awareness Month, a campaign that has boosted better treatments, ... is possible that even they may be a victim // of ... be worse than for women, mainly because of the lack of ... the symptoms: a lump, pain or sensitivity, or a clear or ...
... combat minor infections has always been a contentious point ... are generally used, amoxicillin was considered // the relatively ... University of Iowa have their way. , ,These ... infections caused sever damage to the developing permanent teeth. ...
... estimated to have the highest number of diabetics ... US following closely. Type II Diabetes, one of ... gaining // epidemic proportions throughout the world, with ... diseases. Since diabetes causes significant morbidity and mortality ...
... when it comes to surgery that has to be addressed ... extended by this unique patient. Therefore every attempt has to ... thought clowns only displayed their talent in the circus shows- ... operating room may relax anxious children who are about to ...
... of the most common causes of sexually transmitted infection (STI) ... exist, most of which are harmless. HPV is a virus, ... grow in the anal, genital, oral cavities or respiratory locations ... most easily recognized sign of genital HPV infection. The presence ...
Cached Medicine News:Health News:Common, cheaper drugs could be used to treat hypertension 2Health News:Men Victims Of Breast Cancer? 2Health News:A new anti diabetic drug on the anvil 2
(Date:4/17/2015)... April 17, 2015 Contego Medical, the ... Protection™ filter platform for angioplasty balloon and stent ... million Series B financing round led by Hatteras ... a focus on medical devices, biopharmaceuticals, diagnostics and ... included Mountain Group Partners, Lookout Capital and Medical ...
(Date:4/17/2015)... LifeScienceIndustryResearch.com announces having a ... Global and China Lysine Industry to its research ... the deep research report in this field. For ... including definition, classification specifications, application, industry chain structure, ... Europe , Japan , ...
(Date:4/17/2015)... 2015 CVS Health Corporation (NYSE: CVS ... May 1, 2015, at 8:30 a.m. (EDT) with analysts ... An audio webcast of the conference call ... of the CVS Health website for all interested parties. ... webcast will be archived and available on the web ...
Breaking Medicine Technology:Contego Medical Closes $5.6 Million in Series B Funding 2Contego Medical Closes $5.6 Million in Series B Funding 3Lysine Market International (US, Europe, Japan) Research Analysis 2Lysine Market International (US, Europe, Japan) Research Analysis 3Lysine Market International (US, Europe, Japan) Research Analysis 4Lysine Market International (US, Europe, Japan) Research Analysis 5
... BETHESDA, Md., June 9, 2011 Vertex Pharmaceuticals Incorporated ... from an ongoing Phase 2 study evaluating combinations of ... defective protein that causes cystic fibrosis. The ... most common CF mutation, known as Delta F508. The ...
... June 9, 2011 Located in Doniphan, MO the Bureau of ... USA who cannot afford to pay for their prescriptions out-of-pocket. ... with the fear that they or a family member will not ... insurance or a drug benefit . Members of "Big Pharma" ...
Cached Medicine Technology:Phase 2 Study of Two Potential CF Therapies — VX-770 and VX-809 — Shows Promising Results in Patients with Most Common Mutation 2Bureau of Prescription Health Gives the Whole Truth (and Nothing But) About Free Medicine at FreeMedicine.com 2
Bottega Venetas new collection expresses a unique style and determined personality: discreet elegance and refined luxury are the themes that inspire the creation of these new models, destined to beco...
Classic, stylish, and preppy, this collection features men's, women's and unisex styles....
... the elegant and sophisticated woman, ... includes ophthalmic and sunwear styles. ... variety of shapes and colors, ... shapes and complexions. Many styles ...
The Nine West Eyewear collection is positioned to present today's styles with a sharp, edgy contemporary attitude tied into a clean design element....
Medicine Products: