Navigation Links
New cancer gene found
Date:5/8/2008

OKLAHOMA CITY Researchers at the OU Cancer Institute have identified a new gene that causes cancer. The ground-breaking research appears in Natures cancer journal Oncogene.

The gene and its protein, both called RBM3, are vital for cell division in normal cells. In cancers, low oxygen levels in the tumors cause the amount of this protein to go up dramatically. This causes cancer cells to divide uncontrollably, leading to increased tumor formation.

Researchers used new powerful technology to genetically silence the protein and reduce the level of RBM3 in cancerous cells. The approach stopped cancer from growing and led to cell death. The new technique has been tested successfully on several types of cancers breast, pancreas, colon, lung, ovarian and prostate.

We are excited about this discovery because most cancers are thought to come from mutations in genes, and our studies, for the first time, have shown that too much of this type of protein actually causes normal cells to turn into cancer cells, said Shrikant Anant, Ph.D., a cancer biologist at the OU Cancer Institute and principal investigator on the project.

Anant said they found RBM3 protein in every stage of many cancers, and the amount of protein increased as the cancer grew. The protein helped the cancer grow faster, avoid cell death and was part of the process that formed new blood vessels to feed the tumor.

This process, called angiogenesis, is essential for tumor growth and suggests that targeting RBM3 may be an extremely powerful tool against many and perhaps all solid tumors, Anant said.


'/>"/>

Contact: Diane Clay
diane-clay@ouhsc.edu
405-271-2323
University of Oklahoma
Source:Eurekalert

Page: 1

Related medicine news :

1. FasterCures President Greg Simon Testifies to U.S. Senate HELP Committee on Cancer Challenges and Opportunities in the 21st Century
2. Skin flaps deliver cancer-fighting therapy, ASPS study reveals
3. Breast Cancer Tends to Grow Faster in Younger Women
4. Breast cancer tumors grow faster in younger women
5. Researchers find gene location that gives rise to neuroblastoma, an aggressive childhood cancer
6. UAB first in US to offer speedier precise cancer radiotherapy
7. Researchers Find Gene Location That Gives Rise to Neuroblastoma, an Aggressive Childhood Cancer
8. Gene Variation Linked to Neuroblastoma, a Childhood Cancer
9. Dutch Authorize Manufacture of Vaccinogens New Cancer Vaccine; License Clears Path to European Production, Final FDA Trial
10. Aflac CEO Funds Breast Cancer Symposium in Honor of Companys African-American Female Employees
11. Lung Cancer Alliance Advocate Wins Golf Digest Contest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... NJ (PRWEB) , ... May 03, 2016 , ... ... BCBSNJ) today announced that it has been honored as one of the nation’s ... the 2016 InformationWeek Elite 100. Horizon received the recognition for technology achievements that ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... pharmacies, will be represented at the 2016 Asembia Specialty Pharmacy Summit held May ... is the largest U.S. health care conference for the specialty pharmacy industry, with ...
(Date:5/3/2016)... Texas (PRWEB) , ... May 03, 2016 , ... ... today announced that it is launching a new client service center in La ... Houston, Texas, and will provide the full range of Empyrean client services. , ...
(Date:5/3/2016)... ... ... Park Cities Pet Sitter has openings for both full-time and part-time ... 75219, 75220, 75225, 75229, 75230, 75231 and 75235 zip codes. These zip codes ... and Park Cities areas of the Metroplex. Candidates must love animals, have attention ...
(Date:5/3/2016)... ... 2016 , ... For the sixth consecutive year, Crawford Technologies ... companies in the annual Branham300 listing. For 23 years, the Branhan300 has highlighted ... revenue. , “We are honored to be on the Branham300 list once ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... Leading Economies with Fastest Real GDP Annual Percentage Change, ... 8 Ireland 7.8 India 7.3, , Source: IMF and TechSci ... comprises of Brazil , Russia , ... Africa , registered the fastest GDP growth during the first decade of ... , recession in Brazil and Russia ...
(Date:4/29/2016)... COUNTY, Calif. , April 29, 2016 /PRNewswire/ ... industry is projected to shift from systems dependent ... replace all types of modality CRT Medical monitors ... Although there are a host of foreseeable benefits ... serious concern; will existing modalities have to be ...
(Date:4/29/2016)... 29, 2016 Automation is one ... due to the growing demands for productivity in speed, ... automated systems are already adept of a wide range ... and manual labor. Instrumentation continues to evolve, and is ... just a few years ago. Originally used mostly by ...
Breaking Medicine Technology: