Navigation Links
New cancer gene found

OKLAHOMA CITY Researchers at the OU Cancer Institute have identified a new gene that causes cancer. The ground-breaking research appears in Natures cancer journal Oncogene.

The gene and its protein, both called RBM3, are vital for cell division in normal cells. In cancers, low oxygen levels in the tumors cause the amount of this protein to go up dramatically. This causes cancer cells to divide uncontrollably, leading to increased tumor formation.

Researchers used new powerful technology to genetically silence the protein and reduce the level of RBM3 in cancerous cells. The approach stopped cancer from growing and led to cell death. The new technique has been tested successfully on several types of cancers breast, pancreas, colon, lung, ovarian and prostate.

We are excited about this discovery because most cancers are thought to come from mutations in genes, and our studies, for the first time, have shown that too much of this type of protein actually causes normal cells to turn into cancer cells, said Shrikant Anant, Ph.D., a cancer biologist at the OU Cancer Institute and principal investigator on the project.

Anant said they found RBM3 protein in every stage of many cancers, and the amount of protein increased as the cancer grew. The protein helped the cancer grow faster, avoid cell death and was part of the process that formed new blood vessels to feed the tumor.

This process, called angiogenesis, is essential for tumor growth and suggests that targeting RBM3 may be an extremely powerful tool against many and perhaps all solid tumors, Anant said.


Contact: Diane Clay
University of Oklahoma

Page: 1

Related medicine news :

1. FasterCures President Greg Simon Testifies to U.S. Senate HELP Committee on Cancer Challenges and Opportunities in the 21st Century
2. Skin flaps deliver cancer-fighting therapy, ASPS study reveals
3. Breast Cancer Tends to Grow Faster in Younger Women
4. Breast cancer tumors grow faster in younger women
5. Researchers find gene location that gives rise to neuroblastoma, an aggressive childhood cancer
6. UAB first in US to offer speedier precise cancer radiotherapy
7. Researchers Find Gene Location That Gives Rise to Neuroblastoma, an Aggressive Childhood Cancer
8. Gene Variation Linked to Neuroblastoma, a Childhood Cancer
9. Dutch Authorize Manufacture of Vaccinogens New Cancer Vaccine; License Clears Path to European Production, Final FDA Trial
10. Aflac CEO Funds Breast Cancer Symposium in Honor of Companys African-American Female Employees
11. Lung Cancer Alliance Advocate Wins Golf Digest Contest
Post Your Comments:
(Date:10/13/2015)... ... 2015 , ... A child without a healthy mouth is much more likely ... invisible aligner system, has joined with Global Dental Relief (GDR) to help ... treatment plan purchased, SmileCareClub will donate one clinic visit to a child in Kenya. ...
(Date:10/13/2015)... , ... October 13, 2015 ... ... Omega-3, a first-of-its kind product that targets the unique health needs of ... of the American Pregnancy Association ( ), utilizes Nordic Naturals’ exclusive, ...
(Date:10/13/2015)... ... ... Tempe Dental Care, a leading Tempe dentists’ office, celebrates offering gentle, pain free sedation ... than 5 years. A leading cause of emergency room visits, school absences, and missed ... , Sedation dentistry provides an anxiety-free dental experience with safe and ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... According to ... Rose suffered an orbital fracture when a teammate accidentally elbowed him in the left ... Rose's recent eye injury is just one of a series of setbacks, including a ...
(Date:10/13/2015)... ... October 13, 2015 , ... CVS/pharmacy, the retail division ... for enrolling and serving insurance consumers who do not have a bank account, ... monthly premiums. In “Health Plan Engagement Strategies: The ABCs of Serving Consumers Who ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... World Thrombosis Day Interactive Infographic ...   --> World Thrombosis Day Interactive ... promote vital global awareness of thrombosis, its causes, ... the formation of potentially deadly blood clots in ... thromboembolism (VTE) - or the artery (arterial thrombosis) [1] ...
(Date:10/12/2015)... the United States . By early next year, ... the United States . By early next year, ... The University of Texas MD Anderson Cancer Center, Elekta and ... Tesla) MRI-guided linear accelerator in the United States ... a non-clinical capacity. Royal Philips (NYSE: PHG ...
(Date:10/12/2015)... , Oct. 12, 2015 ... the setbacks and the needs of the medical membrane ... of membrane devices within the different medical membrane devices ... blood microfilters/apheresis systems and membrane diagnostic devices. - Gain ... in this market. --> Use this report ...
Breaking Medicine Technology: