Navigation Links
New breast cancer risk model quantifies the impact of risk reduction
Date:6/24/2011

How much can a woman lower her risk of breast cancer by losing weight, drinking less, or exercising more? A study published online June 24 in the Journal of the National Cancer Institute describes a new model to estimate the impact of these lifestyle changes on absolute breast cancer risk, suggesting risk reductions that could translate into a substantial number of prevented cancers across an entire population.

Breast cancer risk models are widely used to estimate a woman's chances of developing the disease. These are based on non-modifiable risk factors such as age and family history of breast cancer and on modifiable lifestyle factors. But there is little information on how much lifestyle changes would reduce absolute breast cancer risk in individuals and in the population.

In this study, Elisabetta Petracci, Ph.D., and Mitchell Gail, M.D., Ph.D., at the National Cancer Institute and colleagues developed the model using data from an Italian case-control study with more than 5,000 women. Their model includes five risk factors that are difficult or impossible to modify (reproductive characteristics, education, occupational activity, family history, and biopsy history) and three risk factors that are more modifiable (alcohol consumption, leisure physical activity, and body mass index).

The model predicted that changes in the more modifiable risk factors would reduce the absolute risk of developing breast cancer by quantifiable amounts. The average 20-year reduction in absolute risk among women aged 65 was 1.6% in the entire population; 3.2% among women with a positive family history of breast cancer; and 4.1% among women with the most non-modifiable risk factors.

The authors note that the results may help in designing programs aimed at encouraging lifestyle changes. For instance, in a general population of 1 million women, even a 1.6% absolute risk reduction amounts to 16,000 fewer cases of cancer. In contrast, a 3.2% reduction in a higher-risk group--postmenopausal women with a family history--amounts to only 2,560 fewer cases, according to the model.

The authors conclude that these results give perspective on the potential public health impact of reducing exposure to such risk factors and could be useful for designing studies to test the efficacy of prevention programs.

In an accompanying editorial, Kathy J. Helzlsouer, M.D., of Mercy Medical Center in Baltimore writes that the study "provides extremely important information relevant to counseling women on how much risk reduction they can expect by changing behaviors, and also highlights the basic public health concept that small changes in individual risk can translate into a meaningful reduction in disease in a large population." However, she also points out that these estimates are based on optimistic assumptions of changes in behaviors and that the results do not necessarily apply to people in other countries, such as the U.S., where breast cancer rates among older women are much higher than in Italy.

"These differences, however, serve to emphasize the need for models such as these to be created on the basis of local data to provide the best estimates of risk to aid decision making, whether for the individual or the population in public health settings," she writes.


'/>"/>

Contact: Caroline McNeil
caroline.mcneil@oup.com
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... ... December 06, 2016 , ... ... authorized OSHA Training Institute Education Center headquartered in Northern California, has announced the ... providing occupational safety and health training to public sector employees. , “The primary ...
(Date:12/5/2016)... , ... December 05, 2016 , ... "FCPX Overlay Glare ... but natural lighting effect without heavy rendering or complicated compositing," said Christina Austin - ... media to create an organic spectrum of lights that simulates the look of a ...
(Date:12/5/2016)... (PRWEB) , ... December 05, 2016 , ... ... announced it has been featured in SuperbCrew magazine, a leading online tech news ... world. This interview, now featured on SuperbCrew.com, explores the state of enterprise mobility ...
(Date:12/5/2016)... ... December 05, 2016 , ... “Epilepsy Awareness,” ... tomorrow, December 6th, sparks a conversation about epilepsy, bearing down on the social ... people will be diagnosed with epilepsy within their lifetime. With such a large ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... lines. The goal of Castlewood Treatment Centers has always been to promote the ... as many people as possible. In that spirit, Castlewood has announced two new ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Dec 5, 2016 Research and ... by Product (Instruments, Consumables), Application (Biomedical & Biochemical Research, Disease Diagnostics), ... Global Forecasts to 2021" report to their offering. ... , , ... 730.7 Million in 2021 from USD 574.8 Million in 2016, growing ...
(Date:12/5/2016)... 5, 2016 According to a new market ... Transplantation, Growth Factor Technology, Tissue Scaffolds, Cell-free composites), Application (Hyaline Cartilage, ... market is projected to reach USD 779.8 Million by 2021 from ... during the forecast period of 2016 to 2021. ... ...
(Date:12/5/2016)... India , December 5, 2016 According to a ... Type and by Application - Global Opportunity Analysis and Industry Forecast, 2014 - ... is expected to reach $5,255 million by 2022, growing at a CAGR of ... with more than four-fifths share. Continue Reading ... ...
Breaking Medicine Technology: