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New book presents comprehensive survey of research into the molecular basis of aging

COLD SPRING HARBOR, N.Y. In recent years, significant progress has been made in aging-related research. In an authoritative new book published by Cold Spring Harbor Laboratory Press (, leading scientists present recent research advances on the molecular basis of aging, such as the identification of genes that regulate aging and the relationship between diet and aging. They also discuss the potential for developing new drugs to regulate aging and ameliorate aging-related diseases, including Alzheimers disease and cancer.

The book, entitled Molecular Biology of Aging (, is the first to comprehensively cover this field in a single volume. It is an essential source of information for researchers, clinicians, and anyone interested in the field of biogerontology.

Molecular Biology of Aging was edited by three leading experts in the field, Lenny Guarente, Linda Partridge, and Douglas Wallace, each of whom contributed chapters to the book.

Guarentes chapter focuses on sirtuins, which are enzymes that function as critical regulators of aging-related processes in many organisms. He recently authored the popular book Ageless Quest (, also published by Cold Spring Harbor Laboratory Press, in which he provides a personal account of his pursuit of a cure for aging.

Partridges chapter explores the genetics, evolution, and physiology of aging using Drosophila as a model. Her work has shown that single-gene mutations can extend lifespans, and has uncovered physiological trade-offs related to longevity, such as reproduction rate and dietary intake.

Molecular Biology of Aging begins with Wallaces chapter, which discusses the role of mitochondria in aging. His current research focuses on mutations in mitochondrial genes and their role in neurodegenerative diseases, cancer, and aging. His laboratory is developing medications that someday may mitigate the effects of aging in humans.

Other leading scientists contributed chapters in their areas of expertise, such as calorie restriction, telomeres, stem cells, gene networks, DNA repair, and stress resistance. Significant space is devoted to aging-related diseases, such as cancer, Parkinsons disease, cardiovascular disease, Alzheimers disease, and Progeria. The book also contains chapters on specific model organisms, including C. elegans, mice, and yeast, which discuss how each species has contributed to our understanding of the aging process.


Contact: Ingrid Benirschke
Cold Spring Harbor Laboratory  

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