Navigation Links
New bone-targeting drug delays onset of metastases in hormone-resistant prostate cancer patients
Date:9/24/2011

groups of the disease and demographic variables such as age, ethnicity, and geographical location. From this we can conclude that, whatever the patient characteristics (initially based on a high prostate specific antigen (PSA) value [3] and/or a short PSA doubling time), denosumab can delay the appearance of bone metastasis. In a condition where there is currently no effective treatment, this is a highly significant finding," Prof Oudard will say.

According to the researchers, patients with bone metastases have an almost five times higher risk of death compared with patients without bone metastases. "Effective therapies are already in place for both early (hormone-sensitive) and advanced (hormone-resistant) prostate cancer, but until now there was a gap in the treatment plan for this group of patients, who are hormone-resistant but have not yet developed metastatic disease," says Prof Oudard.

The trial showed that the adverse effects of the drug were limited, being relatively similar between both the denosumab and the placebo groups. Low blood calcium levels and osteonecrosis of the jaw, a deterioration of the jawbone, were slightly more frequent in the denosumab group, and back pain was the most commonly reported adverse effect in this group.

"Bone is one of the most common places for cancer to spread, and we believe that it is a very fertile environment for tumour cells," says Prof Oudard. "When cancer spreads to bone, the tumour cells settle in their new micro-environment and continue to grow. Once established, they increase the breakdown of bone, which releases an excess of growth factors back into the blood stream, which then further stimulate tumour growth."

Patients with bone metastases face critical complications. Often the first symptom is pain, which can be severe and debilitating in the majority of patients. Growth of the tumour in the bone weakens the bone itself and puts the patients at risk for serious skeletal-relat
'/>"/>

Contact: Mary Rice
mary.rice@riceconseil.eu
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Phase II study shows new cancer drug combination significantly delays breast cancer progression
2. Emergency treatment for heart attack improving but delays still occur
3. ADHD Drug Delays Puberty in Male Monkeys, Study Finds
4. One-Third of Severe Heart Attack Patients Have Treatment Delays
5. Many Pediatricians Arent Testing Tots for Developmental Delays
6. Hospital Delays Tied to Racial Divide in Heart Attack Care
7. Delays in Hospital Transfers for Heart Attack Patients May Raise Death Risk
8. Language Delays Seen in Kids in Institutions Beyond Age 2
9. Antifungal drug delays need for chemo in advanced prostate cancer
10. FDA Panel Delays Action on Dyes Used in Foods
11. Outcomes improved by longer delays between heart attacks and elective surgeries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... Lake Orion, Clarkston, Metamora, Michigan (PRWEB) , ... ... ... by Movestrong, has launched a new weight management program that is unique to ... highly recommended programs in Oakland and Macomb County. , WEmovestrong’s weight management ...
(Date:8/31/2015)... ... , ... Coast Dental Vista is celebrating its recent grand opening ... p.m. near Albertsons in the Foothill Center, located at 1279 E. Vista Way. There ... Jay Lopp. Call (760) 208-2518 for more details or stop by on September 5. ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... formed in 2008, the result of a merger of five of the busiest ... cooperatively, they could provide more cost-effective and higher quality care than they did ...
(Date:8/31/2015)... Aliso Viejo, CA (PRWEB) , ... August 31, 2015 , ... With the FCPX LUT ... to footage. A LUT is a Lookup Table that contains a mathematical formula for modifying ... table. This pack comes with 60 soft CUBE LUT files. , FCPX LUT Soft requires ...
(Date:8/31/2015)... ... August 31, 2015 , ... Nine innovative healthcare companies (listed ... in Healthcare(SM) Awards Event , on October 21, 2015, in Long Beach. The ... organizations and individuals who are dramatically reducing the cost of quality healthcare. , ...
Breaking Medicine News(10 mins):Health News:Discover How to Replace Missing Teeth, Reduce Cavities, and Restore Oral Health During Coast Dental’s Open House in Vista, CA on Sept. 5, 2015 2Health News:Discover How to Replace Missing Teeth, Reduce Cavities, and Restore Oral Health During Coast Dental’s Open House in Vista, CA on Sept. 5, 2015 3Health News:NJ Top Docs Presents, Garden State Urology! 2Health News:Pixel Film Studios, FCPX Plugin Developer, Releases FCPX LUT Soft 2Health News:9 Finalists Named for Innovations in Healthcare(SM) ABBY Awards; Winners to be Chosen October 21 in Long Beach, CA 2Health News:9 Finalists Named for Innovations in Healthcare(SM) ABBY Awards; Winners to be Chosen October 21 in Long Beach, CA 3Health News:9 Finalists Named for Innovations in Healthcare(SM) ABBY Awards; Winners to be Chosen October 21 in Long Beach, CA 4Health News:9 Finalists Named for Innovations in Healthcare(SM) ABBY Awards; Winners to be Chosen October 21 in Long Beach, CA 5Health News:9 Finalists Named for Innovations in Healthcare(SM) ABBY Awards; Winners to be Chosen October 21 in Long Beach, CA 6Health News:9 Finalists Named for Innovations in Healthcare(SM) ABBY Awards; Winners to be Chosen October 21 in Long Beach, CA 7Health News:9 Finalists Named for Innovations in Healthcare(SM) ABBY Awards; Winners to be Chosen October 21 in Long Beach, CA 8
... Serve as Founding Advisory Board Members and Judges -- LAS ... a leading global information and media company and the CLIO ... design competitions, today announced the launch of the ... innovation in communications in the healthcare industry. The new ...
... CommunityPORTLAND, Ore., May 12 Bishops Barbershop franchises, cuts ... in keeping Portland a great place to live. From ... making cash donations to various groups that support the ... shelters, partnering with other local organizations to help those ...
... and Eyewear Can Minimize Risk of Injury and Improve ... Sports enthusiasts -- athletes and spectators alike -- ... on athletic fields, tracks and golf courses -- placing ... and potential damage from the harmful effects of the ...
... demonstrates commitment to combating a leading killer of children ... released two new reports today that show that the ... to clear evidence on child mortality by targeting resources ... leading killer of children under age five worldwide, is ...
... of Atypicals In Major Depression Treatment Is Growing, ... Forecasts Between Pristiq and Effexor XR Need to ... 12 Decision Resources, one of the world,s ... and healthcare issues, finds that Forest Laboratories, Lexapro ...
... Reusable Charts Help Patients Manage Their Daily and Weekly ... working to improve the healthcare industry as a whole, ... making a difference on a smaller scale.Goss, a medical ... do more. "I feel good about what I do ...
Cached Medicine News:Health News:The Nielsen Company Launches First-Ever CLIO Healthcare Awards Acknowledging Creative Excellence in Healthcare Communications 2Health News:The Nielsen Company Launches First-Ever CLIO Healthcare Awards Acknowledging Creative Excellence in Healthcare Communications 3Health News:Bishops Barbershop - Keeping Portland a Great Place to Live 2Health News:Think Eye Protection This Season and All Year-Round 2Health News:Think Eye Protection This Season and All Year-Round 3Health News:Two New Reports Highlight Stalled Progress Against Diarrheal Disease: Nearly 1.6 Million Children Die Each Year From These Preventable and Treatable Diseases 2Health News:Two New Reports Highlight Stalled Progress Against Diarrheal Disease: Nearly 1.6 Million Children Die Each Year From These Preventable and Treatable Diseases 3Health News:Two New Reports Highlight Stalled Progress Against Diarrheal Disease: Nearly 1.6 Million Children Die Each Year From These Preventable and Treatable Diseases 4Health News:Lexapro Loses First-Line Position for the Treatment of Major Depression 2Health News:Lexapro Loses First-Line Position for the Treatment of Major Depression 3Health News:Healthcare Professional Is Working to Make a Difference, One Dose at a Time 2
(Date:8/31/2015)... Calif. , Aug. 31, 2015  Regulatory ... and government, where regulations are often strict and ... is driving a demand for professionals who have ... these regulations across a product lifecycle and demonstrate ... The University of California, Irvine Extension , ...
(Date:8/31/2015)... , Aug. 31, 2015 Regen BioPharma, ... development of a novel means of delivering its ... RGBP-248, to liver tumors utilizing a clinically approved ... overcomes previous hurdles with gene silencing therapeutics in ... delivered throughout the whole body.  By utilizing a ...
(Date:8/31/2015)... MOUNTAIN VIEW, Calif. , Aug. 31, ... EURONEXT: SAN) and the life sciences team at Google ... and outcomes for people with type 1 and type ... and devices with Google,s expertise in analytics, miniaturized electronics ... how to improve diabetes care by developing new tools ...
Breaking Medicine Technology:UC Irvine Extension Launches New Regulatory Affairs and Compliance Certificate Program 2UC Irvine Extension Launches New Regulatory Affairs and Compliance Certificate Program 3Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 3Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 2Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 3Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 4Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 5Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 6
6.3X Zoom Ratio - Boasting magnifications from 0.8X to 5X, the twin zooming objective optical system developed exclusively by Nikon provides a zoom ratio of 6.3:1. Clickstops at 1X intervals allow ob...
... With a zoom ratio of ... 0.75X to 11.25X, and the ... intervals from 1X to 11X, ... Magnifications of 3.75X to 540X ...
Inquire...
Fluar objectives have been designed especially for qualitative and quantitative analyses of ion movements and for particularly critical fluorescence methods (e.g. chromosome studies in human and cyto...
Medicine Products: