Navigation Links
New biomarker predicts response to hepatitis C treatment
Date:8/16/2009

ith the favorable (CC) genotype had a significantly higher rate of response to treatment (53.3 percent) than did individuals of European ancestry who had the less favorable (TT) genotype (33.3 percent).

The researchers also ran tests to see if the presence of the biomarker was related in any way to viral load, a measure of how much virus was circulating in the patient before treatment started. They found a significant association in all groups. "Interestingly, we found that the C allele, although associated with better treatment response, was associated with a higher viral load at baseline something we have traditionally viewed as a negative prognostic marker when it comes to treatment response," says McHutchison.

That finding, along with other evidence gleaned in the research, suggests that patients who have the beneficial genetic marker might be especially adept at spontaneously clearing the virus through some as yet unknown mechanism, says McHutchison. "It was thrilling to discover such an important biological marker related to response to hepatitis C treatments, but at the same time, the findings tell us there is a lot more work to do before we can fully understand how patients' immune systems protect them from the virus."

"This stunning finding supports the integration of research efforts that previously were not connected," says Robert Califf, M.D., vice chancellor for clinical research and director of the Duke Translational Medicine Institute. "Drs. Goldstein, McHutchison and colleagues have combined world class genotyping and clinical trials management in an academic medical center with an industry sponsored clinical trial to produce a set of findings that are likely to change practice. Their focus on modification of clinical outcomes is especially important to note as we design future studies."

Some members of the research team are interested in finding a way to routinely test for the new marker, but McHutchison say
'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. First biomarker discovered that predicts prostate cancer outcome
2. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
3. Study makes progress in zoning in on biomarkers for better colon cancer treatment
4. New Ovarian Cancer Biomarker Research Act Introduced
5. Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
6. Singulex Announces Presentation on Monitoring of Cardiac Biomarker to Assess Transient Myocardial Ischemia at the American Heart Association Scientific Sessions
7. Biomarker may be an early predictor of advanced breast cancer
8. Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
9. Biomarkers predict risk for invasive breast cancer years before the tumor develops
10. JDRF and Lilly partner to fund research to identify beta cell biomarkers
11. Biomarkers for Alzheimers disease can be trusted in clinical trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The U.S. Pharmacopeial Convention is pleased to announce that ... at North Carolina State’s College of Veterinary Medicine has ... for Distinguished Volunteer Service—the organization’s highest award. , ... volunteer experts to direct its work to improve the ...
(Date:1/22/2015)... The City of West Hollywood hosted a news conference on Thursday, ... of the Supreme Court decision Roe v. Wade, which legalized abortion ... Roe vs. Wade decision and the fight to protect a women’s ... of West Hollywood Councilmember Abbe Land. “We need to continue to ...
(Date:1/22/2015)... 22, 2015 Padre Murphy's and Owner Tom ... Pro Player Health Alliance (PPHA). The PPHA's passion ... getting everyone, including NFL greats, treated for obstructive sleep apnea ... groups supporting the cause in the valley. The most recent ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering ... follow it on Facebook, Twitter, and Pinterest. The fans will ... draws a lottery every week. , Moreover, the company has ... Click Angelweddingdress homepage for more information. , ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 The federal court ... the U.S. District Court, Southern District of West Virginia has ... in that proceeding’s first bellwether trial. In an Order dated ... new trial after finding that C.R. Bard had not proven ...
Breaking Medicine News(10 mins):Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4
... to Keep Kids from Smoking,Save Lives, Statement ... Kids, WASHINGTON, Nov. 5 North Dakota ... kids and health by approving,Measure 3, a state ... lower health care costs by increasing funding for ...
... Education has found its way onto the soccer fields ... experiment that may have all the right ingredients to change ... , Despite overall advances in medical care and treatment, Latinos ... than whites, a medical fact especially significant in North Carolina, ...
... Fayette,County,s largest employers will expand and create more than ... 20-year investment by the commonwealth., Uniontown Hospital will ... Redevelopment Authority, on behalf of the Fayette Regional,Health System, ... used to jump start the construction of a new,inpatient ...
... eye care facility in Tanzania to,be honored with ... Nov. 5 Today, Seva,Foundation proudly honors the ... preventable blindness around the world -- Dr. Paul,Courtright ... Center for Community Ophthalmology (KCCO),which Courtright and Lewallen ...
... in the journal of Minerva Cardioangiologica reveals Pycnogenol, pine ... jetlag in passengers by nearly 50 percent. The two-part ... scoring system, showed Pycnogenol lowered symptoms of jetlag such ... both healthy individuals and hypertensive patients. Passengers also experienced ...
... Life,(AUL) today released analysis of the results of ... initiatives on,abortion defeated in California, Colorado, and South ... and,destructive embryonic stem cell research in Michigan were ... of AUL said: "We applaud the work,of those ...
Cached Medicine News:Health News:North Dakota Votes to Keep Promise to Kids by Fully Funding Tobacco Prevention 2Health News:New HIV-reduction initiative takes to the fields 2Health News:New HIV-reduction initiative takes to the fields 3Health News:State to Invest $8.4 Million in Uniontown Hospital's Expansion 2Health News:Seva Foundation Recognizes Paul Courtright and Susan Lewallen for Their Commitment to Blindness Prevention 2Health News:Seva Foundation Recognizes Paul Courtright and Susan Lewallen for Their Commitment to Blindness Prevention 3Health News:Study shows pine bark reduces jetlag 2Health News:Study shows pine bark reduces jetlag 3Health News:Americans United for Life Assesses State Ballot Initiative Outcomes, Predicts Regrouping and Strong Comeback in Next Election Cycle for Life Issues 2Health News:Americans United for Life Assesses State Ballot Initiative Outcomes, Predicts Regrouping and Strong Comeback in Next Election Cycle for Life Issues 3
(Date:1/23/2015)... 23, 2015  HyGreen, Inc., a leader in hand hygiene ... RCA Medical, a subsidiary of Ascendis Health Limited, in ... Each year, hundreds of millions of patients around the ... are transmitted from patient to patient via the unwashed ...
(Date:1/23/2015)... 2015 Cord Blood America, Inc. ( www.cordblood-america.com ) (OTC ...  filed a Preliminary Proxy Statement, Schedule 14A, with the U.S. ... an update for shareholders detailing why a "YES" vote to ... Dear Shareholders, As we reflect upon the 2014 ...
(Date:1/23/2015)... Gem Pharmaceuticals announced today that the initial soft ... Company,s Phase 2 clinical trial.  This open-label study will ... GPX-150 (an investigational medication), in approximately 30 adults as ... Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO GPX-150 ...
Breaking Medicine Technology:HyGreen Partners with RCA Medical in Johannesburg, South Africa 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2
... 13, 2011 Science, public health, and regulatory highlights ... in this document is designed for credentialed journalists. Release dates ... 2011. (Logo:   http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... regulatory or enforcement actions due to legal limitations. ...
... Md., June 13, 2011 The Foundation for the National ... Management Systems Society (HIMSS) and the National Institutes of Health ... research, technology, business and policy for the 2011 mHealth Summit. ... the mHealth Alliance, HIMSS and NIH, the 3rd annual mHealth ...
Cached Medicine Technology:2011 mHealth Summit: Call for Research Abstracts and Speakers Now Open 22011 mHealth Summit: Call for Research Abstracts and Speakers Now Open 32011 mHealth Summit: Call for Research Abstracts and Speakers Now Open 4
Inquire...
Inquire...
...
... on decades of experience, the SSD-1000 is ... system. It uses our advanced technologies and ... Using the same technology as our more ... capabilities in a compact and mobile setting., ...
Medicine Products: