Navigation Links
New artemisinin-based treatment against malaria promising
Date:11/8/2011

ANTWERP For some time now, artemisinin, derived from a Chinese herb, has been the most powerful treatment available against malaria. To avoid the malaria parasite becoming resistant, the World Health Organisation (WHO) strongly recommends combining artemisinin with another anti-malarial drug. But there are different formulations and derivatives, in different combinations and with dosing schemes. Scientists from the Institute of Tropical Medicine (ITM) carried out a head-to-head comparison of four combination therapies in seven African countries. One combination appeared particularly promising for regions where the risk of re-infection is high.

Malaria is caused by several related parasites, of which Plasmodium falciparum is the worst. The parasites have a complicated life cycle, partly in mosquitoes. When an infected mosquito bites a human, parasites are injected with the mosquito saliva into the blood, travel to the liver, where they change form, then infect red blood cells, where they further reproduce. After a few days (depending on the parasite species), the red blood cells burst to release a huge number of new parasites. These bursts cause intense fever, anaemia, renal problems. Each year, about 800 000 people die of malaria.

In recent years, the burden of malaria has declined substantially in several sub-Saharan African countries, due to large scale indoor residual spraying of insecticides, massive distribution of insecticide-treated bed nets, and the introduction of artemisinin-based combination treatments, ACTs for short. To treat patients with malaria the WHO advises each region to choose an ACT based on the local level of resistance to non-artemisinin medicine in the combination. But data on that resistance are scarce.

The ITM scientists, who also took part in the recent trials of the first effective malaria vaccine, compared four ACT treatments, in more than 4 000 randomised children less than 5 years of age with uncomplicated malaria, in twelve sites distributed in seven sub-Saharan African countries. This is the largest such study on ACT ever done in Africa. Three of the regimes had excellent and similar efficacy in treating the malaria attack, but of those, treatment with combination dihydroartemisinin-piperaquine (the combination most recent recommended by the WHO) resulted in significantly fewer recurrent infections. The development of resistance should be closely monitored, the scientists advise, but this new therapy clearly shows great promise.


'/>"/>

Contact: Umberto D'Alessandro
udalessandro@mrc.gm
220-717-9580
Institute of Tropical Medicine Antwerp
Source:Eurekalert

Related medicine news :

1. New Bypass Surgery for Stroke Riskier Than Drug Treatment
2. Northern Ireland company makes major breakthrough in cancer treatment
3. Major project to implement new treatments to boost kala-azar elimination strategies
4. Study identifies factors linked with better medication response for treatment of juvenile arthritis
5. More Targeted Treatments Key to Progress in War on Cancer: Report
6. Wayne State therapeutic marijuana use study could impact state policies, guide treatment
7. Gene therapy shows promise as hemophilia treatment in animal studies
8. Researchers reveal potential treatment for sickle cell disease
9. ASU leads $5 million NIH-sponsored research initiative to advance diabetes care and treatment
10. New research on improved treatment options and screening strategies for Hepatitis C
11. Folate receptors may serve as a front door to ovarian cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
Breaking Medicine Technology: