Navigation Links
New approaches to protecting transplanted organs make first steps toward patients
Date:12/3/2008

ctions. Long-term IDO therapy could do that as well: "That is part of the experiment we still need to look at," Dr. Mellor said. However it also may be that short-term IDO inducer therapy will enable long-term graft survival. "It may get it through that window of difficulty."

The team also will explore the more localized approach used by fetuses and tumors, where specific tissue puts up a sort of immune barrier by expressing IDO. They'll use a powerful viral vector as a vehicle to deliver the IDO gene directly into the tissue to be transplanted, turning the cells into "IDO over-expressers," Dr. Mellor said.

The vector was developed with the help of Georgia Research Alliance funding and Dr. Yukai He, a member of the MCG Cancer Center's Immunotherapy Program and GRA Distinguished Investigator who specializes in cancer vaccine development.

"We have to try both directions: putting the IDO gene in locally or giving it systemically. We know the mechanism works in principle: that IDO is a good way to protect transplants. But we don't know what is the most effective way," Dr. Mellor said.

Mason Trust funds also will enable expansion of studies in human samples by Dr. Anatolij Horuzsko, an immunologist in the MCG Center for Molecular Chaperone/Radiobiology and Cancer Virology, and Dr. Laura Mulloy, chief of the Section of Nephrology, Hypertension and Transplantation Medicine in the School of Medicine.

Several forms of HLA-G are effective at inhibiting the immune response similar to the way fetuses and tumors use IDO but Dr. Horuzsko has shown the dimer version comprised of two chemically attracted monomers or molecules is the best HLA-G at blocking transplant rejection in a mouse with a skin graft.

He already has measured HLA-G dimer levels in the blood of more than 50 kidney transplant patients and found pretty much what he's seen in his animal studies: those who don't reject their new kidneys have higher levels o
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Employers “Vote” on Presidential Candidates' Health Care Platforms: Prefer Middle Ground Between the Two Approaches
2. Presidential candidates health plans offer divergent approaches to health system reform
3. Ingenious Med Continues Record Customer Growth and Approaches Key Milestones
4. Studies test new approaches to islet transplantation
5. Retooling Talent Management Approaches to Find, Grow & Retain Tomorrows Leaders
6. New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland
7. Routinely used diagnostic approaches: only limited diagnostic sensitivity for bile duct cancer?
8. Mathematical modeling offers new approaches to fight dual-resistant hospital infections
9. Doctors uncertain about approaches to care for heart failure patients, SLU study finds
10. Research Highlights New Approaches to Management of Blood Clotting and Bleeding Disorders
11. Pediatricians Awarded for Innovative Approaches to Combat Childhood Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New approaches to protecting transplanted organs make first steps toward patients
(Date:3/28/2015)... New York, NY (PRWEB) March 28, 2015 ... clinic that offers urgent care in Manhattan, recently commemorated ... urgent care facility in Manhattan. In addition to 24-hour ... to ER facilities. , At this time, Emergency ... treatments for abdominal pain, asthma, chest pain, eye injuries, ...
(Date:3/28/2015)... 28, 2015 Pitching speed, player’s height, and ... shoulder and elbow injuries, according to new research released today ... ) Specialty Day. , “Our findings indicate that a 10 ... in likelihood of a history of injury, a 10 mile ... increase likelihood of a history of injury, and playing for ...
(Date:3/28/2015)... 2015 Early surgery may not be ... AC joint injuries, according to new research from Tripler ... American Orthopaedic Society for Sports Medicine’s ( AOSSM ) ... when surgery was not performed. , The final study ... treatment and 17 receiving non-surgical therapy. Of the non-surgery ...
(Date:3/28/2015)... Omaha, NE (PRWEB) March 28, 2015 ... leader in healthcare staffing, including physical therapy jobs, ... exhibitor at the Ohio Physical Therapy Association Annual ... the Renaissance Columbus Downtown Hotel in Columbus, OH. ... programming, networking opportunities, and exhibits with products and ...
(Date:3/28/2015)... ARDX will sponsor the 7th Annual Women’s Wellness ... Chesapeake Conference Center in Chesapeake, Virginia. Each year, ARDX ... women in the Hampton Roads region. The 2015 Women’s ... Women grow stronger through sharing their stories and learning ... the WWC™ theme is T-talk where we will share a ...
Breaking Medicine News(10 mins):Health News:Emergency Medical Care Celebrates Three Years of 24/7 Walk-In Urgent Care Services 2Health News:Researchers Highlight Shoulder and Elbow Injury Possibility in Youth Players 2Health News:For Type V AC Joint Injuries, Early Surgery May Not Be the Best Approach 2Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the Ohio Physical Therapy Association Annual Conference 2
... ... wife and husband team of doctors, is a finalist in the Sixth Annual ... technologies, and Epocrates, the premier provider of medical decision support tools for doctors ... health blog until midnight Sunday, February 14. , ...
... ... Implementation of New Infrastructure Technologies. , ... (PRWEB) December 11, 2009 -- Data Strategy, a trusted leader of ... that helps customers evaluate the benefits of deploying Avamar deduplication backup software. SurePath ...
... , , CHICAGO , Feb. 11 ... a life-saving gift this Valentine,s Day by declaring disease-causing E. ... for them.   E. coli O157:H7 was declared ... the west coast outbreak that sickened over 700 people and killed ...
... , WESTPORT, Conn. , Feb. 11 ... resident and Zeta Interactive CEO, Al DiGuido , announced ... this evening from Aitoro,s Appliances in Norwalk, CT . , ... 2010, will feature live entertainment and dancing, top-quality dining from several ...
... , , NORFOLK, Va. Feb. 11 ... piloted his Cessna 208 Caravan to Santo Domingo, Dominican ... remarkable airlift of Operation Smile medical volunteers and supplies into Hinche, ... Mr. Ford decided to volunteer his time, piloting skills and aircraft ...
... study finds , THURSDAY, Feb. 11 (HealthDay News) -- A ... discharge a patient who has come to the emergency room ... artery calcium scoring (CACS) test detects coronary artery disease. A ... detailed image of the heart that shows calcium build-up in ...
Cached Medicine News:Health News:CelebrityDiagnosis.com Nominated as Best New Medical Blog of 2009 2Health News:CelebrityDiagnosis.com Nominated as Best New Medical Blog of 2009 3Health News:Data Strategy Announces SurePath Services Offering for EMC Avamar 2Health News:Data Strategy Announces SurePath Services Offering for EMC Avamar 3Health News:Six Other E. coli's Could Be Lurking In Your Valentine Day's Dinner 2Health News:Al's Angels' 'Love and Laughter' Event to Support Children and Families in Desperate Need 2Health News:Al's Angels' 'Love and Laughter' Event to Support Children and Families in Desperate Need 3Health News:Actor and Humanitarian Harrison Ford Assists Operation Smile's Relief Efforts in Haiti 2Health News:Actor and Humanitarian Harrison Ford Assists Operation Smile's Relief Efforts in Haiti 3Health News:Actor and Humanitarian Harrison Ford Assists Operation Smile's Relief Efforts in Haiti 4
(Date:3/27/2015)... , March 27, 2015  The quality function within ... ensure products meet quality standards at every stage of ... regulations, quality leaders also have the challenge of balancing ... Those who don,t effectively balance these priorities risk ... as marketplace failure and regulatory scrutiny. For ...
(Date:3/27/2015)... /PRNewswire/ - Medicure Inc. (the "Company") (TSXV:MPH, OTCQB:MCUJF) announces ... grant of an aggregate of 236,070 options to certain ... the Company pursuant to the Company,s Stock Option Plan. ... the tenth anniversary of the date of grant, 5,000 ... the date of grant and 50,000 are set to ...
(Date:3/27/2015)... , March 27, 2015 Biopharmaceutical Industry ... biopharmaceutical industry comes out on top as the country,s ... new report  from ndp│analytics. According to the  analysis ... (R&D) investment over the last decade, accounting for 27 ... A Short Video on Medicare Part ...
Breaking Medicine Technology:New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2Week in Review: The Latest from PhRMA 2
... SHENZHEN, China , May 6 /PRNewswire-Asia-FirstCall/ -- China Nepstar Chain,Drugstore Ltd. ... in China based on the number of directly operated stores,announced today ... March 31, 2010 , before the market opens on, Wednesday, May 19, ... ...
... SCOLR Pharma, Inc. (NYSE AMEX: DDD ... Agreement with RedHill Biopharma Ltd. an Israeli corporation, (RedHill), ... ondansetron tablet formulations based on SCOLR,s proprietary extended delivery ... Zofran®, GlaxoSmithKline,s drug to prevent chemotherapy and radiation related ...
Cached Medicine Technology:China Nepstar Chain Drugstore Reports First Quarter 2010 Results on May 19 2China Nepstar Chain Drugstore Reports First Quarter 2010 Results on May 19 3SCOLR Pharma, Inc. Enters into Worldwide Licensing Agreement with RedHill Biopharma Ltd. 2SCOLR Pharma, Inc. Enters into Worldwide Licensing Agreement with RedHill Biopharma Ltd. 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: