Navigation Links
New approaches to protecting transplanted organs make first steps toward patients
Date:12/3/2008

AUGUSTA, Ga. - Methods used by the body to selectively suppress the immune response may help make organ transplants safer and more effective, according to scientists.

"If you like, what we are trying to do is make every tissue transplant much more like a fetus," said Dr. Andrew L. Mellor, director of the Medical College of Georgia Immunotherapy Center and Georgia Research Alliance Eminent Scholar in Molecular Immunogenetics.

He's referencing how the genetically different fetus, which should be attacked by the mother's immune system, escapes by using powerful immune suppressors such as the enzyme indoleomine 2,3-dioxygenase. The lungs, liver, gut and eyes are examples of other human tissues that make use of this type of selective immune suppression to deal with routine contact with foreign, albeit usually harmless substances.

A new $1 million, three-year grant from Atlanta-based Carlos and Marguerite Mason Trust, administered by Wachovia Nonprofit and Philanthropic Services, will fund pre-clinical research exploring the most effective method for increasing IDO levels to improve transplant survival. The grant also will help explore the role of HLA-G dimer, another powerful immune modulator, in transplant survival and look for biomarkers that would give physicians a heads up that a rejection episode is mounting.

Using the model of a mouse with a skin graft, Dr. Phillip Chandler, a transplant biologist in Dr. Mellor's lab, will use IDO stimulators before, during and after a transplant. They'll also use IDO inhibitors to further define IDO's role in graft survival. "That is how we will learn if IDO can be induced and if that expression protects transplants," Dr. Mellor said. "This is proof of concept we are talking about which gets us toward the clinic."

Current immunosuppressive therapies for transplant patients cause a generalized suppression of the immune response that puts them at increased risk for cancers and infe
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Employers “Vote” on Presidential Candidates' Health Care Platforms: Prefer Middle Ground Between the Two Approaches
2. Presidential candidates health plans offer divergent approaches to health system reform
3. Ingenious Med Continues Record Customer Growth and Approaches Key Milestones
4. Studies test new approaches to islet transplantation
5. Retooling Talent Management Approaches to Find, Grow & Retain Tomorrows Leaders
6. New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland
7. Routinely used diagnostic approaches: only limited diagnostic sensitivity for bile duct cancer?
8. Mathematical modeling offers new approaches to fight dual-resistant hospital infections
9. Doctors uncertain about approaches to care for heart failure patients, SLU study finds
10. Research Highlights New Approaches to Management of Blood Clotting and Bleeding Disorders
11. Pediatricians Awarded for Innovative Approaches to Combat Childhood Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New approaches to protecting transplanted organs make first steps toward patients
(Date:4/14/2014)... treat children with uncomplicated acute appendicitis is a reasonable ... fewer missed school days, according to a pilot study. ... Hospital and published online April 12 in the ... the first prospective study on nonoperative management of acute ... , Researchers enrolled 77 patients age 7 to 17 ...
(Date:4/14/2014)... 2014, Perth, Australia. Drug discovery company Proteomics International ... of a companion diagnostic (CDx) test with the ... The research team authenticated the panel of biomarkers ... samples. Seven biomarkers were validated at high stringency ... The mass spectrometry data was then cross-validated using ...
(Date:4/14/2014)... 2014) When it comes to the cost and ... Patients get the best care when they are treated ... extensive experience in their current job, according to a ... and Columbia Business School. The study was published in ... Applied Economics . , The review of more ...
(Date:4/13/2014)... STANFORD, Calif. A low-cost empowerment program for ... and sexual harassment of these girls, who live ... and are frequently attacked, a large new study ... Stanford University School of Medicine, Lucile Packard Children,s ... No Worldwide, validated the program,s effectiveness in combating ...
(Date:4/11/2014)... the processes that control brain cell production could pave ... brain-related disorders. , Scientists have gained new understanding of ... how and when nerve and brain cells are formed ... and keeps it healthy. Their findings could help explain ... which is a fundamental characteristic of many diseases including ...
Breaking Medicine News(10 mins):Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 2Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 3Health News:Longer nurse tenure on hospital units leads to higher quality care 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 3Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 4
... , ATLANTA, Sept. 4 Blue Cross Blue Shield of ... already available to its group life insurance beneficiaries by offering a new ... loved one - The Healing Book: Facing the Death and Celebrating ... published by Watering Can Press). , , The ...
... , , , ... Access(SM), the nation,s leading provider of vascular access management services, ... awarded the 2009 Gerald A. Beathard Fellowship in Interventional Nephrology. ... pioneers in Interventional Nephrology and Lifeline,s Vice President of Provider ...
... Kan., Sept. 4 The path to poor hand sanitation is ... North Carolina State Universities. , , As college ... the researchers said students, actions will speak louder than words. , ... hands," said Douglas Powell, an associate professor of food safety at ...
... researchers have developed a new approach to identify ... to drugs and how they become resistant. This ... result in leukemia and associating specific mutations with ... how drug resistance occurs in leukemia and other ...
... ABBOTT PARK, Ill., Sept. 4 For the fourth consecutive year, Abbott (NYSE: ... to Launch a Career" by BusinessWeek magazine. The list highlights ... year, Abbott moved up to No. 13, and was once again the top-ranked ... list every year since BusinessWeek initiated the list in 2006. , ...
... suggests officials might need to rethink strategies , ... that officials in the United States, United Kingdom and ... because the current strategies -- emphasizing healthy diets and ... online Sept. 4 in BMJ , Australian researchers ...
Cached Medicine News:Health News:Blue Cross Blue Shield of Georgia Offers The Healing Book to Help Young Life Insurance Beneficiaries Cope with Losing a Loved One 2Health News:Gerald A. Beathard Fellowship Awarded to Dr. Stephen Osaguona 2Health News:Gerald A. Beathard Fellowship Awarded to Dr. Stephen Osaguona 3Health News:Getting College Students To Wash Hands, Halt Disease, Requires Giving Them Proper Tools and Spreading The Word In Ways That Get Attention, Say K-State Expert and Colleague 2Health News:New research strategy for understanding drug resistance in leukemia 2Health News:New research strategy for understanding drug resistance in leukemia 3Health News:Abbott Again Named One of the 'Best Places to Launch a Career' by BusinessWeek 2Health News:Abbott Again Named One of the 'Best Places to Launch a Career' by BusinessWeek 3
(Date:1/14/2014)... BEVERLY HILLS, Calif. , Jan. 14, 2014 ... , offers Los Angeles a premier ... Duality laser and a $99 treatment special. Dr. Brandeis, focus ... medical technology and offering expert medical advice to all patients. ... a dramatic increase in the presence of tattoo regret and ...
(Date:1/14/2014)... 2014 Animal Emergency Critical Care, a LifeCentre partner practice, ... is the first in Loudoun County ... Dr. Susan M. Barnes , Medical Director, is a ... Dr. Cole Taylor , are avid scuba divers. "As altitude ... when air is thin," states Dr Barnes. She goes on to ...
(Date:1/14/2014)... --  Oligomerix, Inc. , a privately held company ... Alzheimer,s disease (AD) and related neurodegenerative disorders, announced ... Valhalla, NY as of ... additional laboratory space at New York Medical College. ... development of small molecule drugs aimed specifically at ...
Breaking Medicine Technology:Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... EORTC 40983 (EPOC),Intergroup Study Results, CHICAGO, June ... phase III EORTC 40983 Intergroup study, or ... peri-operative (pre and post,surgery) FOLFOX4 (Eloxatin(R) (oxaliplatin ... for colon cancer,5-fluorouracil/leucovorin (5-FU/LV)) given to patients ...
... Phase II Study Results Presented at Society ... 04, 2007 /PRNewswire-FirstCall/ --,Immunomedics, Inc. , a ... treat cancer and other serious,diseases, today announced ... with the radioisotope,iodine-131, was found to be ...
Cached Medicine Technology:The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 2The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 3The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 4The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 5The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 6The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 7The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 8The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 9Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and,Effective in Colorectal Cancer with Liver Metastases 2Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and,Effective in Colorectal Cancer with Liver Metastases 3Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and,Effective in Colorectal Cancer with Liver Metastases 4Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and,Effective in Colorectal Cancer with Liver Metastases 5
Superior comfort and flexibility are achieved through the revolutionary air pocket technology in the dimpled, ultra-thin SoftFlex skin barrier along with a discreet pouch shape and size....
Inquire...
Inquire...
Flextend is a hydrocolloid skin barrier that is designed to be the most resistant to discharge and is the barrier of choice for urostomies and high output ileosotomies....
Medicine Products: