Navigation Links
New approaches in treating complicated childhood polycystic kidney disease
Date:4/26/2013

A collaborative team of physician-scientists at the Medical College of Wisconsin (MCW) and Children's Hospital of Wisconsin Research Institute has developed a new evidence-based, clinical algorithm to help physicians treat complex patients with autosomal recessive polycystic kidney disease (ARPKD).

Their invited manuscript, written by Grzegorz Telega, M.D., associate professor of pediatrics (gastroenterology and hepatology) at MCW and program director of hepatology at Children's Hospital of Wisconsin; David Cronin, II, M.D., Ph.D., professor of surgery and member of the new Transplantation Institute; and Ellis D. Avner, M.D. professor of pediatrics (nephrology) and physiology at MCW, and director of the Multidisciplinary Childhood PKD Program (MCPP) at Children's Hospital of Wisconsin Research Institute, appears in the April 17 edition of Pediatric Transplantation http://onlinelibrary.wiley.com/doi/10.1111/petr.12076/full.

ARPKD is a rare genetic disorder that causes progressive disease of the kidneys and liver. Of the patients with ARPKD who survive the first year of life, more than 85 percent will reach their tenth birthday. However, despite dramatic improvements in overall survival and quality of life, nearly 50 percent of those survivors develop end stage kidney disease during that time.

Based on a comprehensive analysis of published medical literature, unique insights generated from the MCPP (established in 2005 and the only such program in the U.S.) and more than 50 years of clinical experience by the authors in treating complex problems in ARPKD patients, an algorithm was developed to guide patient therapy. Of particular note, the authors recommend an innovative approach for a subgroup of ARPKD patients with severe kidney and liver disease: simultaneous kidney and liver transplantation.

"We believe combined liver-kidney transplantation can potentially decrease overall mortality and morbidity in carefully selected ARPKD patients with end stage renal disease and clinically significant congenital hepatic fibrosis," said Dr. Avner. "This is a particularly attractive option at our center, given the rapid growth of the joint solid organ transplantation program between Children's Hospital of Wisconsin, Froedtert Hospital, the Medical College of Wisconsin, and the BloodCenter of Wisconsin, directed by Dr. Johnny Hong."

The authors also emphasize that this therapy only be considered in major pediatric organ transplant centers with experienced pediatric transplant surgeons, subspecialty physicians and nurses, and complete pediatric ancillary services. The commentary also includes a "tree" to help guide clinicians making decisions about the appropriate course of treatment for complications of ARPKD.


'/>"/>

Contact: Maureen Mack
mmack@mcw.edu
414-955-4744
Medical College of Wisconsin
Source:Eurekalert

Related medicine news :

1. Daily-use HIV prevention approaches prove ineffective among women in NIH study
2. Common Sense Approaches May Stem ICU Delirium
3. Jan 31 W-2 1099 Form Mailing Deadline Approaches: EzW2 Software Helps Small Businesses Get Form Ready in Time
4. Cutting-edge approaches to ensuring biologic drug quality focus of forum on bioassays
5. As painkiller overdoses mount, researchers outline effective approaches to curb epidemic
6. NIH awards $7.8 million for innovative HIV vaccine approaches
7. GWU consensus report outlines new approaches for evaluating benefits and risks of obesity drugs
8. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
9. Treating Hemorrhoids
10. How “Hemorrhoids No More” Helps People Treat Hemorrhoids Quickly – V-kool
11. Treating Allergies with Traditional Medicine: Ayurvedic Medicine During the Spring Season 2013
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... ... December 03, 2016 , ... "Perfect Harmony comes with ... allowing FCPX editors to create professional looking video in a matter of minutes," ... contains a beautifully designed 3D environment for placing in personal media. Twenty pre-made ...
(Date:12/4/2016)... Aliso Viejo, California (PRWEB) , ... December 04, ... ... self-animating lower third presets that have new attractive animation styles with unique displacement ... Pro3rd Displace features 30 pre-animated lower third designs. Choose from a variety of ...
(Date:12/2/2016)... ... December 02, 2016 , ... Halfway through its partnership with First 5 ... services to more than 15,900 children 5 years old and younger and treatment services ... over a span of five years to Western University of Health Sciences, UCLA and ...
(Date:12/2/2016)... ... 02, 2016 , ... For over twenty-four years, Doctors on Liens has published a ... find high quality medical care. When the company started in 1997, the directory was ... present day and the now ten-page directory features a vast array of medical specialists ...
(Date:12/2/2016)... ... ... Center for Autism and Related Disorders (CARD) Portland today announced plans to ... and other developmental disabilities. The group, which is being launched with the help of ... to share stories and advice, seek help, and continue their education on how to ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... December 2, 2016 On Thursday, ... honored excellence in research, development and innovation in the ... dinner was held in the presence of Sergey Tsyb, ... Russian Federation , Natalia Sanina, First Vice ... Murashko , Head of Roszdravnadzor, National Service of Control ...
(Date:12/2/2016)... Columbia , December 2, 2016 bioLytical Laboratories, ... INSTI HIV-Selbsttest, bei den Mitgliedern des Apothekenbundes von Kenia eingeführt. ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) ...
(Date:12/2/2016)... 2, 2016 Lianluo Smart Limited (Nasdaq: ... Company") which develops, markets and sells medical devices ... China and international markets, recently attended ... Treatment New Progress Forum, co-hosted by the Institute ... , Guangdong Provincial People,s Hospital and Cardiology ...
Breaking Medicine Technology: