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New approach which can help to predict neurodegenerative diseases
Date:7/26/2010

o the great transport networks between cities or ports. The cargo 'vehicles' used for this transport are mostly the vesicles, small lipid spheres that arise from the cell organelle and are transported to another cell organelle. This transport is exquisitely regulated and the defects that may arise could be the cause of the illness.

Many proteins act together for sustaining life, forming what are known as protein complexes (a series of proteins that develop a specific function). The GARP complex is the transport network that recycles receptors of acid hydrolases from the lysosomes (the stomach of the cell) to the Golgi apparatus. Acid hydrolases are enzymes which, in the acidic medium of the lysosomes, are activated and digest other proteins. To avoid the receptors themselves being digested by the acid hydrolases, once the interior of the lysosomes is acidified, these recycle to the Golgi by means of transport vesicles. In this way, the receptors are recycled and reused to transport new acid hydrolases to the lysosomes. In concrete, the GARP complex is formed by four proteins and is responsible for physically tying up the vesicles that are transported to the destination organelle, in this case the Golgi apparatus, something similar to a vessel being moored at a port. Subsequently the vesicles fuse to discharge their transported content.

The study concluded that the wobbler phenotype is the consequence of a drastic reduction in the levels of the GARP complex, one that is required to tie up the transport vesicles to the Golgi apparatus. This drop in the levels of the GARP complex thus breaks with the normal functioning of the recycling route of the acid hydrolase receptors to the Golgi apparatus.


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Contact: Oihane Lakar
o.lakar@elhuyar.com
0034-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

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