Navigation Links
New approach which can help to predict neurodegenerative diseases
Date:7/26/2010

ns or defects that generate reduced levels of the GARP complex or instability therein", explained Dr Hierro.

There exists a study undertaken at the University of Michigan by Dr. Brown with 96 patients suffering from sporadic ALS and in which this mutation present in the wobbler mouse was not found and so it can be concluded that this mutation has no great presence amongst humans. "Nevertheless, the great similarity between the GARP complex proteins of the mouse and amongst humans means that such that a motorneurodegenerative effect in humans due to reduced levels of the GARP mooring complex cannot be discarded This opens the possibility for studying these levels in humans where, moreover, it will be possible to predict the illness well before the appearance of symptoms", explained Dr Hierro. "It is highly likely that many patients with some motorneurodegenerative disease do not have the same mutation as the wobbler mouse but there does exist the possibility that, due to some other reason, some patients may have reduced levels of the GARP complex, a situation which gives rise to the illness", stated Dr Hierro.

To carry out this research, various techniques such as x-ray crystallography, together with bioinformatic analysis, have been used, enabling resolving for the first time the structure of the mentioned protein in the region where the mutation is produced. Subsequently a combination of in vitro experiments were undertaken using biophysical techniques, as well as in vivo ones using various mouse cell lines and tissues with the wobbler phenotype, and it was confirmed that the mutation produces a destabilising effect on the Vps54 protein, an effect that is subsequently transmitted to the rest of the components of the GARP protein complex.

Regulation of cell 'traffic'

The metabolic balance of the cell largely depends on the correct transport of components amongst the various cell organelles, something similar t
'/>"/>

Contact: Oihane Lakar
o.lakar@elhuyar.com
0034-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Survival benefit with high-intensity end-of-life approaches
2. Mountain Home 'Doing the Right Thing Really is the Best Business Approach'
3. ICU Patients Gain From Team Approach to Care
4. Short on specialized intensive care physicians, team-based approach improves ICU outcomes
5. Lumension Unveils Intelligent Application Whitelisting that Operationalizes a Proactive Endpoint Security Approach
6. Secretary Clintons Approach to Development: Good Rhetoric, Little Action?
7. New Approaches to Teen Therapy Bring Results
8. New Drugs, Approaches Offer Hope Against Prostate Cancer
9. New approach to immune cell analysis seen as first step to better distinguish health and disease
10. Reovirus may be a novel approach to prostate cancer treatment
11. Effort aims to spike breast cancer with new approach
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... in multitasking and ways to train it have been ... universitaire de griatrie de Montral and the University of ... the effectiveness of this training. Cooking while having a ... driving while listening to a radio show ... Unfortunately, it decreases with age, which makes it harder ...
(Date:8/19/2014)... August 20, 2014 Recently, iFitDress.com,a leading ... outfits, has unveiled its new collection of pewter ... to expand the company’s global market. Each item is ... the company’s senior spokesman, customers that have specific requirements ... iFitDress.com. Now, all the brand new items are offered ...
(Date:8/19/2014)... -- Lupus and other rheumatic diseases can cause ... can delay a correct diagnosis for months, a ... can also cause these types of symptoms, according ... in Maywood, Ill. Rheumatic disorders include autoimmune and ... such as lupus, systemic vasculitis and ankylosing spondylitis. ...
(Date:8/19/2014)... from Glasgow where he helped distribute thousands of The ... 23 – August 6), Pete Dwan is a man with ... for his work cannot be overstated. , According to UK ... A drugs within the last year. And that doesn’t take ... to be “legal highs” until June 2014, when the UK ...
(Date:8/19/2014)... the longtime standard treatment for atrial fibrillation, is ... drug marketplace including dabigatran, rivaroxaban, and apixaban. A ... novel oral anticoagulants (NOACs) into clinical practice. By ... anticoagulant prescriptions yet this represents 98% of total ... The American Journal of Medicine . , Atrial ...
Breaking Medicine News(10 mins):Health News:Targeted brain training may help you multitask better 2Health News:Discounted Pewter Evening Dresses For 2014 Unveiled By Company iFitDress.com 2Health News:Certain Symptoms Can Delay Lupus Diagnosis, Researchers Report 2Health News:British Scientologist on a Mission to Save Youth from Drug Abuse 2Health News:Novel oral anticoagulant prescriptions soar, but at a high cost 2Health News:Novel oral anticoagulant prescriptions soar, but at a high cost 3
... Oct. 15 Impelsys , a global ... American Academy of Pediatrics (AAP), a ... solidified its e-book strategy with iPublishCentral , ... 350 publishers worldwide. Launching in early 2010, AAP will ...
... DEERFIELD, Ill., October 14, 2009 A study, published ... showed that a greater percentage of patients with type ... (pioglitazone HCl and metformin HCl) as initial therapy reached ... percent compared to either component alone. Safety and tolerability ...
... at reducing the risk of heart attacks and heart ... new report from the Institute of Medicine. The ... secondhand smoke boosts nonsmokers, risk for heart problems, adding ... could lead to a heart attack is compelling. ...
... Program Seeks Adult Athletes to Go the Extra Mile to ... Teen and pre-teen girls face peer pressure, cultural stereotypes ... impact on their futures. That is why former Ironman ... prevention program that prepares girls for a lifetime of self-respect ...
... DIEGO, Oct. 15 Cardium Therapeutics (NYSE Amex: CXM ... to selected investors for aggregate gross proceeds of $6.0 million. ... was filed by Cardium Therapeutics with the Securities and Exchange ... August 15, 2007. Details concerning the terms of the ...
... tradition of capturing celebrity in photograph with 2009 Christmas ... Lung Association has brought back a time-honored tradition this ... a photograph with the 2009 Christmas Seal. This ... distinguished list of celebrities and entertainers who have served ...
Cached Medicine News:Health News:Leading Society Publisher, American Academy of Pediatrics, Chooses iPublishCentral to Launch e-Book Strategy 2Health News:Leading Society Publisher, American Academy of Pediatrics, Chooses iPublishCentral to Launch e-Book Strategy 3Health News:New data showed type 2 diabetes patients experienced greater blood sugar reductions 2Health News:New data showed type 2 diabetes patients experienced greater blood sugar reductions 3Health News:New data showed type 2 diabetes patients experienced greater blood sugar reductions 4Health News:New data showed type 2 diabetes patients experienced greater blood sugar reductions 5Health News:Smoking bans reduce the risk of heart attacks associated with secondhand smoke 2Health News:Girls on the Run Inspires Girls to Recognize and Achieve Their Potential Through the Power of Running 2Health News:Girls on the Run Inspires Girls to Recognize and Achieve Their Potential Through the Power of Running 3Health News:Cardium Announces $6.0 Million Registered Direct Offering 2Health News:Cardium Announces $6.0 Million Registered Direct Offering 3Health News:S. Epatha Merkerson Lends Star Power to Support the American Lung Association's Christmas Seals Campaign as Celebrity Chairperson 2
(Date:8/19/2014)... DUBLIN , Aug. 19, 2014 ... the "Pharmaceutical Contract Manufacturing - Global Strategic Business ... This report analyzes the worldwide markets for Pharmaceutical Contract ... Injectables (Injections, Vials, and IV solutions), Solid Dosage Forms ... (Syrups, Suspensions, Gels, Creams & Ointments). The ...
(Date:8/19/2014)... , Aug. 19, 2014 Research and Markets ... by Type of Material, by Technology, by Application & by ... their offering. The demand for membranes is ... driving the market to $29.31 billion Membrane technology ... applications, such as water filtration and kidney dialysis. In modern ...
(Date:8/19/2014)... According to Kalorama Information, electronic medical records ... Data in healthcare a reality, and this a factor ... American Recovery and Reinvestment Act, the U.S. government dedicated ... penalties will start applying soon for use of paper ... study of the EMR industry, EMR 2014: The ...
Breaking Medicine Technology:Global Pharmaceutical Contract Manufacturing - Strategic Business Report 2014 2Global Membranes (MF, RO, UF, Gas Separation, Dialysis, NF) Market - Forecasts to 2019 2Kalorama: EMR Paves the Way for Big Data 2Kalorama: EMR Paves the Way for Big Data 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: