Navigation Links
New approach to prostate cancer screening needed
Date:3/7/2014

The UK needs to invest in testing for those men most at risk of prostate cancer rather than follow a cast-the-net-wide approach targeting the whole population, a leading scientist from The University of Manchester - part of Manchester Cancer Research Centre - has argued at an international conference this week.

Men in the UK are currently entitled to PSA blood test for prostate cancer once they reach the age of 50 and will be recommended to have a prostate biopsy if their PSA level is greater than their age-specific threshold. This practice leaves around 50,000 men in the UK having an unnecessary prostate biopsy every year which is painful, can cause bleeding and infection and rarely even death.

Professor Ken Muir, from The University of Manchester, is proposing the UK moves to a risk-based approach in the community a move backed by Tackle Prostate Cancer formerly the Prostate Cancer Support Federation.

The new approach is a computer generated risk assessment, which will be based on an extension of the Canadian Sunnybrook Risk Calculator (SRC) which utilises a combination of indicators including PSA, PSA free to total (both simple blood based tests), urine symptoms, age, family history, ethnicity and physical examination (DRE: Digital Rectal Exam). Men will only be put forward for prostate biopsy if their prostate cancer risk is calculated to be greater than that of the normal male population.
The calculator will also find more high-grade cancers, the ones that kill 10,000 men per annum, earlier so that they are treatable.

Manchester researchers surveyed more than 1,000 men and over 100 GPs about whether they would be happy with a risk-based approach to prostate cancer screening. The findings show over 80% of men expressed strong support and 77% of GPs were supportive.

The researchers now aim to further identify and include more risk markers and personalise the approach by also using predisposing genetic markers.

Professor Muir said that these markers would potentially replace the digital rectal examination, which in a primary care environment has proved a weak point and a social obstacle in some communities. This would make the calculator more efficient.

Individual personalised risk-calculators have been used in routine practice in many other countries across Europe, Canada and the USA, for some time but their use in the NHS Primary Care has not been investigated.

Professor Muir said: "There is a growing acceptance of using a combination of markers of risk to reduce the over-referral of patients for invasive further assessment and that this assessment should be made in Primary Care."

The European Randomised Screening for Prostate Cancer (ERSPC) trial highlighted limitations of using a PSA threshold in a trial on over 182,000 men across Europe and organisers estimate a risk-based approach to screening would save between a quarter and a third of unnecessary biopsies to detect the same number of cancers.

The Manchester team now hopes to run a trial with General Practices allocated to assess men at risk aged 50-75 but also aged 40-75 who are Afro-Caribbean or who have first degree relatives with prostate or breast cancer using two different approaches. The trial would allocate some of the participants through the risk calculator and the others would just have a PSA test. The results would be compared to ascertain the effectiveness of the risk profiling.

David Smith, Secretary of Tackle and the Patient Expert on the trial said: "Tackle, whose members have invested significant sums in the trial, are confident that the trial team under Professor Muir will produce a risk calculator that is non-inferior. The detection of cancers of definite clinical significance will be increased while significantly reducing the number of men needing to undergo biopsy."


'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert  

Related medicine news :

1. REACT clinical trial supports new approach of accelerated treatment for Crohns disease
2. Researchers find novel approach for controlling deadly C. difficile infections
3. Novel biomarker approach suggests new avenues to improve schizophrenia disease management
4. Craig Stephens as a Marketing Specialist for Plastic Surgeons Offers a Decidedly Unique Approach to Surgeons for Developing Their Online Presence
5. OHSU researchers develop new drug approach that could lead to cures for wide range of diseases
6. Nutrition experts explore dietary approaches that influence type 2 diabetes risk
7. Nasal Polyps Treatment Miracle Review Exposes Manuel Richard’s Natural Approach to Healing Nasal Polyps
8. Diet Doc Hormone Diets & Weight Loss Plans Now Offer Immediate Weight Loss Diet Support, Found to be More Effective than the Self-Help Approach
9. Advanced Back Pain Website Tool is a Viral Approach to Treatment
10. Study looks at better prediction for epileptic seizures through adaptive learning approach
11. Diet Doc Hormone Diets & Weight Loss Plans Now Offer a Unique Approach to Eliminating Body Fat with Exclusive Hormone Diet Treatments and the Low Carb Diet
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New approach to prostate cancer screening needed
(Date:5/2/2016)... ... May 02, 2016 , ... Over $60 Billion is spent annually ... gear and toys, leading product review site for Toys, Tots, Pets & More (TTPM) ... at their Spring Showcase at the Metropolitan Pavilion in New York City. , Chosen ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... MedPro Waste ... mail back service. MedPro now offers its mail back service for an all-inclusive ... we are now able to provide service to all of the clients in the ...
(Date:5/2/2016)... ... May 02, 2016 , ... Further establishing itself as a ... the new WHIMZEES Variety Value Boxes were selected from over 1,000 entrants as a ... , WHIMZEES natural dental chews for dogs are a favorite product among pet-parents ...
(Date:5/2/2016)... , ... May 02, 2016 , ... Dr. Rassouli, ... health and cognitive decline. According to the research, which was published in the “Journal ... of cognitive decline, and about 5.4 million Americans have Alzheimer’s disease. The study found ...
(Date:5/2/2016)... CA (PRWEB) , ... May 02, 2016 , ... The 2016 World Ultimate & Guts ... Ultimate Camp at Manhattan College, made the cut. The WUGC is being held in London, ... Teams won the gold in the men’s division, another gold in the women’s masters division, ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...  The blood testing market in China ... Information and The Freedonia Group in a recent report.  ... The healthcare research firm said that China ... stations and in improving testing at the provincial level.  ... Blood Testing Market in China , which ...
(Date:4/28/2016)... Dr. Vivek Ahuja , ... Ste phen Schmidt Join the ... software solutions for life sciences, today announced key new leaders have ... insight to a growing business.  This will bolster the company,s safety ... joined ArisGlobal in the position of Vice President - Safety. ...
(Date:4/28/2016)... FREMONT, Calif. , April 28, 2016 ... Enterprise Validation Lifecycle Management Solutions (VLMS) today ... products and services for sufferers of chronic ... management System to manage their corporate validation ... been seeking a software solution to manage ...
Breaking Medicine Technology: