Navigation Links
New approach to leukemia chemotherapy -- is a cure in sight?
Date:3/30/2011

Speaking at the UK National Stem Cell Network conference in York later today (31 March), Professor Tessa Holyoake from the University of Glasgow will discuss a brand new approach to treating chronic myeloid leukaemia (CML) in which a small number of cancer cells persist despite effective therapy thus preventing cure.

CML is a type of blood cancer caused by the infamous "Philadelphia Chromosome" genetic abnormality. It is usually treated using a class of drugs called Tyrosine Kinase Inhibitors and in the majority of cases this treatment is successful, with around 90% of patients recovering from the disease. However in the majority of patients a subset of cancer cells CML stem cells are resistant to Tyrosine Kinase Inhibitors.

"At the moment we are working with 9 patients who still have low level evidence of CML despite Tyrosine Kinase Inhibitor treatment. They are helping us to test the use, in principle, of a new type of drug that specifically deals with the resistant CML stem cells," said Professor Holyoake.

"The drug we are using in the trial is hydroxychloroquine a well established antimalarial drug that has been used commonly since the 1950s and is also used in rheumatoid arthritis. This will allow us to test the principle of using similar drugs to treat CML patients.

"Unfortunately hydroxychloroquine may not be suitable for very long term treatment because of side effects. In particular there is a very low risk of temporary or permanent eye problems. In our trial the patients will take the drug for up to 12 months with very close monitoring of their eye health, which will allow us to intervene at the very earliest sign of an adverse effect," Professor Holyoake continued.

The patients in the trial have already taken a Tyrosine Kinase Inhibitor drug for at least a year, which has reduced the number of cancer cells in their blood to a very low level.

Professor Holyoake's team discovered that CML stem
'/>"/>

Contact: Mike Davies
mike.davies@bbsrc.ac.uk
01-793-414-694
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Conference highlights UC Berkeleys unique approach to green chemistry
2. Novel approaches to bacterial caries management: An efficacious solution in view?
3. To bring effective therapies to patients quicker, use the team approach
4. University Hospitals system-approach to stroke care increases the use of tPA therapy by 13.5-fold
5. Experimental approach may improve healing of diabetic wounds and bed sores
6. 3rd international conference on innovative approaches in head and neck oncology
7. Study raises safety concerns about experimental cancer approach
8. NIH, Gates Foundation and Colorado State team up to find new approach to a TB vaccine
9. Tufts University calls for moderate approach to teaching personalized genomic testing
10. Cost of Obesity Approaching $300 Billion a Year
11. Mass. General enters collaboration to develop new approach to capturing circulating tumor cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (PRWEB) January 22, 2015 Yesterday, ... Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were honored ... leadership in advancing biotechnology, biomedical science, medical device ... Olsen each received the “2014 Life Sciences Champion” ...
(Date:1/22/2015)... Colorado (PRWEB) January 22, 2015 Four years since ... Queen – which coincided with the marriage of Avasa & Matthew ... THE ROAD, which is scheduled for release through White Swan Records ... message that there is a sacred path available to all of ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 As interest in ... health care gains momentum worldwide, Rev. Eric J. Hall ... Chaplaincy Network (HCCN), will be the keynote speaker on ... in Israel’s public health system. , The conference, “Hope and ...
(Date:1/22/2015)... 22, 2015 Lower-Auto-Insurance.com has released a new blog ... a car for reducing the costs of an auto insurance ... be able to get lower prices for their vehicle insurance policies. ... role in determining policy costs. Because of this, drivers should ...
(Date:12/26/2014)... 26, 2014 The US represents the largest ... In 2013, GlobalData’s forecast estimates that sales of branded therapies ... due to the high incidence of the disease, high drug ... Japan, and China. Increased sales of CRC therapies over the ...
Breaking Medicine News(10 mins):Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4
... The Penn State College of Medicine,s Department of Public ... million over seven years to act as the data ... Institute,s AsthmaNet. This grant is one of the largest ... of multiple clinical centers across the nation that conducts ...
... skeletal muscles, it may be important to monitor heart ... are the findings from a study conducted by Nationwide ... Human Molecular Genetics . This is the first ... SMA. SMA is a debilitating neurological disease that ...
... HealthDay Reporter , TUESDAY, Aug. 10 (HealthDay News) -- After ... vertebroplasty was no better than a sham procedure in treating ... can, in fact, ease some patients, pain. In this ... into the affected part of the spine. For some ...
... TUESDAY, Aug. 10 (HealthDay News) -- Women,s cholesterol levels vary ... and fall, a new study reveals. This means that ... doctors may need to take readings over several months before ... the researchers noted. "Doctors who are looking at women ...
... near-weightless technology can measure the impact of a dangerous tackle ... and runway traffic, analyze a golf pro,s swing, orient the ... missiles on target. And as sensing devices improve, ... Teams of Tel Aviv University scientists are at the heart ...
... are used in hormone replacement therapies to counteract the ... the risk of uterine cancer. However, evidence in recent ... the risk of breast cancer. Now, University of Missouri ... hormone replacement therapies and found significantly different outcomes on ...
Cached Medicine News:Health News:College Of Medicine receives $54 million grant for asthma research 2Health News:Spinal muscular atrophy may also affect the heart 2Health News:Study Offers Support for Surgery After Compression Fracture 2Health News:Study Offers Support for Surgery After Compression Fracture 3Health News:Cholesterol Levels Fluctuate With Menstrual Cycle 2Health News:Cholesterol Levels Fluctuate With Menstrual Cycle 3Health News:Micromachines for a safer world 2Health News:Breast cancer risk varies among different progestins used in hormone replacement therapy 2
(Date:1/23/2015)... 2015 Tianyin Pharmaceutical Inc. (NYSE Amex: ... development and sale of patented biopharmaceutical medicine, modernized traditional ... (API) today announced the business and development progress at ... 1. Following the September 2014 JCM application (No. 51268) ...
(Date:1/22/2015)... Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" ... on Omega-3 therapies for cardiovascular disease and overall health is ... accomplishments in 2014 and its outlook for 2015 from the ... Shareholders, We would like to take this opportunity ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... "Infectious Disease Diagnostics Market by Product, Application, Technology, ... to their offering. , The infectious disease ... 7.9% to reach $18,156.2 million by 2019 from $12,422.8 ...
Breaking Medicine Technology:TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3
... Boston Scientific Corporation (NYSE: BSX ) ... Foundation of America (AAFA) to support education initiatives designed ...  The Company,s support coincides with Asthma and Allergy Awareness ... more than 20 million Americans suffer from asthma -- ...
... PARIS, May 10, 2011 Groupe Hospitalier Pitie ... largest medical centers has continued its long tradition ... radiation therapy with the acquisition of Leksell Gamma ... Perfexion – Paris,s first and only dedicated radiosurgery ...
Cached Medicine Technology:Boston Scientific Supports Asthma Awareness Month With Donation to Asthma Foundation 2Boston Scientific Supports Asthma Awareness Month With Donation to Asthma Foundation 3Boston Scientific Supports Asthma Awareness Month With Donation to Asthma Foundation 4First-ever Gamma Knife in Paris Offers New Treatment Options for Patients With Cancer and Other Brain Disorders 2First-ever Gamma Knife in Paris Offers New Treatment Options for Patients With Cancer and Other Brain Disorders 3
Substrate Plasma for Factor X Assay by STA© Analyzers. Freeze-dried human plasma from which factor X has been removed by selective immuno-adsorption....
Immuno-turbidimetric Assay of von Willebrand Factor (vWF) Antigen by STA© Analyzers. Microlatex particles coated with rabbit anti-human vWF antibodies....
Enzyme Immunoassay of Factor IX Antigen by ELISA Method, 96 tests....
Enzyme Immunoassay of -Thromboglobulin Antigen by ELISA Method, 96 tests....
Medicine Products: