Navigation Links
New approach to cancer: Find most tightly controlled genes
Date:7/17/2008

DURHAM, N.C., and SINGAPORE Scientists at a Duke University medical school in Singapore have found a new way to study cancer that could be very useful for developing targeted therapies against cancer and possibly many other diseases.

"Because all you need for this approach is gene expression data to compare both diseased and normal tissues, you could apply it to cancer or any other disease, if you have the data," said co-author and researcher Patrick Tan, M.D., Ph.D., associate professor of Duke-NUS Graduate Medical School Singapore. "Just replace the word 'cancer' with 'diabetes,' 'obesity,' and so on."

Surveying large amounts of genetic data, the scientists analyzed both cancerous and healthy, normal tissue for genes with tightly controlled activity.

They defined "tightly controlled" as genes that varied the least during their expression. Gene expression is the process through which a gene is turned on to make certain products, such as proteins.

In cases where the same genes were active in both diseased and normal tissue, they narrowed their search to the genes that are more tightly controlled in cancerous tissue. The diseased and normal samples used came from lung, thyroid, liver, esophagus, colon and breast tissues.

"We thought that since the tumors were spending costly cellular resources and energy to control the expression of these particular genes, they must have functional importance in cancer," said Dr. Tan, who is also a principal investigator with the National Cancer Centre and group leader in the Genome Institute of Singapore.

The work, published in the July 18 issue of PLoS Genetics, was funded by the National Cancer Centre of Singapore and a grant from the Biomedical Research Council of Singapore.

Forty-eight genes that are tightly controlled in tumors emerged from the analysis. The scientists referred to this collection as a "poised gene cassette" or PGC.

"We view
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New approach sheds light on ways Circadian disruption affects human health
2. Kognitio CEO Offers Outsourced, Service-Based Data Warehousing as a New Approach to Large Scale Analytics
3. First steps towards a new approach to epilepsy treatment
4. Non-Surgical Approach Can Treat Lung Cancers
5. Weizmann Institute scientists develop a new approach to treating autoimmune disease
6. New vaccine approach prevents/reverses diabetes in lab study at Childrens Hospital of Pittsburgh
7. NIAID to advance B-cell approach to HIV vaccines
8. Research Converging in Favor of New Approach to U.S. Weight Problem
9. New approach to protect the hearts of patients with muscular dystrophy
10. Teens think they have asthma under control, but benefit from new approach to treatment
11. Studies test new approaches to islet transplantation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... PartnerTech Inc. , a major systems integration ... von Uexkull to their facilities, June 6, 2014 as ... a top trade official from the Embassy of Sweden, ... bring awareness and insight to the business community concerning ... , As an expert on global economy, von Uexkull ...
(Date:7/23/2014)... On July 4th, at the age of 70, ... a first place prize in her age group at the Firecracker ... waited until she was in her forties before becoming an ordained ... start running. Not one to do anything halfway, she launched her ... Kitty, the decision to begin running started five years ago at ...
(Date:7/22/2014)... July 22, 2014 Ticket Down ... vs. Manchester City tickets at Sporting Park in Kansas ... on Wednesday, July 23rd. Tickets can be conveniently printed ... Ticket Down can be reached toll free at 1-877-870-3653. ... are authentic and covered by Ticket Down's customer satisfaction guarantee. ...
(Date:7/22/2014)... 23, 2014 Provectus has ... From now on, in addition to working with the ... for Google Glass as well as the creation of ... A dynamic lifestyle requires special gadgets for work, leisure ... found application in healthcare, logistics, travelling, sports, education, science ...
(Date:7/22/2014)... 2014 Obtaining a bachelor’s degree in ... who have hands-on medical experience. The School of Nursing ... announced the launch of an accelerated nursing degree program ... new program, the UNCG Veterans Access Program (VAP), will ... veterans. With some prior college credit, veterans who are ...
Breaking Medicine News(10 mins):Health News:Swedish Official Tours PartnerTech’s U.S. Facility 2Health News:Swedish Official Tours PartnerTech’s U.S. Facility 3Health News:Naperville, Ilinois’ Monarch Landing Resident Wins First Place in 5K Run 2Health News:Sporting Kansas City vs. Manchester City Tickets: Ticket Down Has Slashed Ticket Prices for Manchester City vs. Sporting Kansas City on July 23rd 2Health News:Provectus Announces Development for Google Glass and Wearables 2Health News:UNCG School of Nursing Fast-Tracks Medically Trained Veterans 2
... Epidural hematoma, is a blood clot between the brain and ... Natasha Richardson died from a blunt impact to the head, ... Monday on a beginner,s ski slope in Canada. , The ... hematoma due to blunt impact to the head," said medical ...
... Encourages Dialog between Patients and PhysiciansALEXANDRIA, Va., March 19 ... their end-of-life wishes with their physicians had significantly lower ... found that these conversations between patients and physicians led ... and resulted in a far more peaceful death for ...
... less invasive than deep brain stimulation, researchers say ... with Parkinson,s-like symptoms walked and moved normally again ... frequency electrical currents, a new study shows. , ... has the potential to be an important new ...
... company cofounded by Beth Israel Deaconess Medical Center (BIDMC) ... has announced that it has closed an $8M Series ... Life Sciences (SVLS) and MedImmune Ventures. , The company ... T-cells, with their first program focusing on treatments for ...
... adds features that benefit both patients and health ... a leading international provider of innovative stroke rehabilitation ... www.saebo.com . The new site is designed ... upper extremity stroke rehab products, while making the ...
... of Pittsburgh School of Medicine have begun testing a vaccine ... at high risk for developing the disease. If shown to ... of repeated invasive surveillance tests, such as colonoscopy, that are ... cancer takes years to develop and typically starts with a ...
Cached Medicine News:Health News:Natasha Richardson Died From Head Trauma: Autopsy 2Health News:Natasha Richardson Died From Head Trauma: Autopsy 3Health News:Discussions About End-of-Life Care Reduce Healthcare Costs in Last Week of Life 2Health News:New Parkinson's Treatment Shows Promise in Animals 2Health News:New Parkinson's Treatment Shows Promise in Animals 3Health News:Biotech company cofounded by BIDMC scientists targets natural killer T-cells 2Health News:Saebo Expands Internet Presence With Launch of New Website 2Health News:Saebo Expands Internet Presence With Launch of New Website 3Health News:Pitt vaccine to prevent colon cancer being tested in patients 2
(Date:7/22/2014)... Pa. , July 22, 2014  Eyeon Therapeutics ... dry eye treatment based on a charged hydrophilic polymer ... The product has been shown to be safe and ... Mitchnick , MD, CEO states, "This first set of ... a long way to moving this technology into the ...
(Date:7/22/2014)... , July 22, 2014 Elekta (NSE:EKTAb) and ... that The Christie NHS Foundation Trust ( Manchester, ... a consortium whose mission is to develop the clinical ... radiation therapy system. Such a system would, in principle, ... cancer targets. "The Christie was an ...
(Date:7/22/2014)... SCHOFIELD, Wis. , July 22, 2014 /PRNewswire/ ... and marketer of over-the-counter (OTC) medicinal and healthcare ... corporate sponsor of Operation Troop Aid. ... said Russell Mitchell , CEO and Chairman ... men and women in combat zones experience migraines ...
Breaking Medicine Technology:Particle Sciences and Eyeon Therapeutics Receive Patent on Novel Dry Eye Technology 2The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 2The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 3The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 4PuraMed BioScience Partners with Operation Troop Aid to Sponsor Care Packages 2PuraMed BioScience Partners with Operation Troop Aid to Sponsor Care Packages 3
... best value in high performance electronic pipetting!, ... lightweight design reduce hand fatigue and strain ... tip ejector , Color coding for easy ... for greater performance use Hamilton AdvanTip Low ...
... Research pro Electronic Pipette is ideal for ... Its easy-to-follow display, ergonomically-placed operating buttons, and ... reverse pipetting and diluting make this a ... functions of a manual pipette without any ...
... The Research pro Electronic Pipette is ... the laboratory. Its easy-to-follow display, ergonomically-placed operating ... pipetting, dispensing, reverse pipetting and diluting make ... the simple functions of a manual pipette ...
... for Unparalleled Comfort Pick one of our ... Notice the trigger and ejector positionsright where they ... pipettors are ergonomically designed to help avoid repetitive ... Productivity In The Palm Of Your Hand ...
Medicine Products: