Navigation Links
New approach identifies cancer mutations as targets of effective melanoma immunotherapy
Date:6/30/2014

PHILADELPHIA A new approach demonstrated that the recognition of unique cancer mutations appeared to be responsible for complete cancer regressions in two metastatic melanoma patients treated with a type of immunotherapy called adoptive T-cell therapy. This new approach may help develop more effective cancer immunotherapies, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

"This study provides the technical solution to identify mutated tumor targets that can stimulate immune responses, which is one of the major bottlenecks in developing a new generation of adoptive T-cell therapy," said Steven A. Rosenberg, MD, PhD, chief of surgery at the National Cancer Institute (NCI) in Bethesda, Maryland. "The two targets identified in this study play important roles in cancer cell proliferation.

"Immunotherapy has the potential to successfully treat cancer by targeting tumor mutations. We've moved one step closer because of this study," Rosenberg added.

Adoptive T-cell therapy is a type of immunotherapy in which the immune cells infiltrating a patient's tumor, so called tumor-infiltrating lymphocytes (TILs, which are T cells), are harvested, activated and expanded in the laboratory, and transferred back to the patient. Such activated cells are capable of efficiently attacking tumor cells.

"In a clinical trial, up to 72 percent of the patients with metastatic melanoma experienced tumor regression after adoptive T-cell transfer. However, not all patients benefited. This is because the specificity of the TILs remains largely unclear. Our goal was to establish an efficient method to identify the specificity of these cells," explained Rosenberg.

The researchers took tumor samples from two patients who had benefited from the therapy and pursued two screening approaches to identify the tumor targets recognized by the clinically effective T cells. First, the
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Unique approach needed to accurately assess health of young adult cancer survivors
2. MU receives national award for using mind-body approach to improve health
3. Global, common approach to pharmaceutical supply chain integrity the focus of workshop
4. Editorial calls for comprehensive approach to cancer screening
5. Rutgers team discovers novel approach to stimulate immune cells
6. National initiative launched to change the way biology departments approach undergraduate education
7. A systems approach to preventing obesity in early life
8. Mount Sinai researchers develop a multi-target approach to treating tumors
9. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
10. A non-antibiotic approach for treating urinary tract infections
11. SingleSource Background Screening Company Calls On Adults To Take Proactive Approach To Stop Child Sexual Abuse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Ticket Down is a reliable source ... at the Sun Life Stadium in early September. , Two ... Brazil and Colombia meet at Sun Life Stadium in Miami Gardens, ... in the world and will be a rematch of their thriller ... kick-off on Sept. 5 and will feature some of the best ...
(Date:8/20/2014)... August 20, 2014 The finalists are ... leading health-marketing industry trade magazine, will honor the pharmaceutical ... Awards are given to outstanding companies, marketers and brand ... , “We are proud to announce that we ... entries with double the number of submissions we received ...
(Date:8/20/2014)... 2014 Botanica Day Spa ... Utilizing the new and popular stem cell line ... lines and wrinkles and naturally repairs the skin. ... the new service by offering clients a complimentary ... cell facial. , Pevonia® continues to be a ...
(Date:8/20/2014)... Brain Tumour Research has been chosen by Plymouth University ... was launched in April 2009 to raise awareness of, ... improve outcomes for brain tumour patients. , A range ... raise funds for the charity, and members of staff ... be encouraged to donate, fundraise and volunteer. The involvement ...
(Date:8/20/2014)... If old age is a disease then this ... extensive research on HGH and stem cells technology, the L.A. ... the art of rubbing off decades from your face and ... their revolutionary anti-aging hormone therapy and regenerative medicine. , ... youth, the MD of MetroMD, Dr Alex Martin said this ...
Breaking Medicine News(10 mins):Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Match 2Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Match 3Health News:PM360 Announces 2014 Trailblazer Award Finalists 2Health News:PM360 Announces 2014 Trailblazer Award Finalists 3Health News:PM360 Announces 2014 Trailblazer Award Finalists 4Health News:PM360 Announces 2014 Trailblazer Award Finalists 5Health News:PM360 Announces 2014 Trailblazer Award Finalists 6Health News:PM360 Announces 2014 Trailblazer Award Finalists 7Health News:PM360 Announces 2014 Trailblazer Award Finalists 8Health News:New Stem Cell Facial Unveiled at Botanica Day Spa 2Health News:New Stem Cell Facial Unveiled at Botanica Day Spa 3Health News:Plymouth University chooses Brain Tumour Research as official charity 2Health News:MetroMD Offers Revolutionary Anti-aging Hormone Therapy in Hollywood Area 2
... Randy Dotinga HealthDay Reporter , TUESDAY, July 27 ... provide companionship: They also may boost your longevity, making as ... of studies suggests. Researchers combined the results of ... may live an average of almost 4 years longer than ...
... Reporter , TUESDAY, July 27 (HealthDay News) -- Infants born ... breathing problems compared with full-term babies, a new study finds. ... and 37th weeks of pregnancy -- account for about 9 ... researchers said. And too often, they are the result of ...
... Intimate partner violence results in 2 million injuries among ... Department of Health and Human Services. University of Missouri ... program that helps women experiencing abuse develop individualized safety ... Unlike current Internet resources, the decision-aid program ...
... Louisville, Ky. Smaller, rural hospitals may be quicker ... their larger, urban counterparts, and are capable of providing ... with major hospitals that provide a comprehensive array of ... led by researchers from the University of Louisville Department ...
... and who have abused their children can stop if they ... new study has found that mothers in families in which ... able to reduce how much they cursed at, yelled at, ... of home visits from therapists who taught them parenting skills. ...
... Ahmed H. Zewail, Ph.D., 1999 Chemistry Nobel Laureate and ... at the California Institute of Technology, has been named ... Chemical Society (ACS). The award recognizes Zewail,s revolutionary ... ultrafast processes in chemistry, biology and materials science. His ...
Cached Medicine News:Health News:Close Ties With Others Might Lengthen Life, Review Finds 2Health News:Delivering Babies Even a Few Weeks Early Ups Respiratory Risks 2Health News:Delivering Babies Even a Few Weeks Early Ups Respiratory Risks 3Health News:Use of decision-aid program increases safety for women experiencing abuse, researchers find 2Health News:Smaller hospitals can provide safe and high-quality surgical care comparable to larger counterparts 2Health News:Smaller hospitals can provide safe and high-quality surgical care comparable to larger counterparts 3Health News:Abusive mothers improve parenting after in-home training, emotional support of therapists 2Health News:Abusive mothers improve parenting after in-home training, emotional support of therapists 3Health News:American Chemical Society's highest honor goes to pioneer in 'ultraslow-motion' imaging 2Health News:American Chemical Society's highest honor goes to pioneer in 'ultraslow-motion' imaging 3
(Date:8/20/2014)... -- Glenmark Pharmaceuticals S.A. (GPSA), a ... (GPL), announces the discovery and initiation of IND ... GBR 1302, a HER2xCD3 bispecific antibody. GBR 1302 ... Research Centre located in La Chaux-de-Fonds, ... Glenmark,s innovative BEAT antibody technology platform which facilitates ...
(Date:8/19/2014)... Aug. 19, 2014  The Alabama Supreme Court, in a ... sue drug makers who mislead doctors into believing that prescription ... case is Weeks v. Wyeth, and the decision came after ... same case last year. Heninger Garrison Davis attorneys Lew ... in the case, Danny Weeks . The ...
(Date:8/19/2014)... 2014 Minimally Invasive Devices Inc. (MID), a ... announced today that Mitsubishi Corporation has formally agreed to ... in Japan . MID anticipates that ... Japan in the second half of 2015. ... for Karl Storz GMBH & Co. (endoscopic instruments and ...
Breaking Medicine Technology:Glenmark Enters Oncology With the Discovery and Initiation of IND Enabling Studies of an Innovative Bispecific Antibody 2Glenmark Enters Oncology With the Discovery and Initiation of IND Enabling Studies of an Innovative Bispecific Antibody 3Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 2Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 3Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 4Minimally Invasive Devices and Mitsubishi Medical Japan Forge Exclusive Distribution Agreement 2
... DATATRAK International, Inc.(OTCQX: DATA), a technology and services ... trials industry, today announced the signing of two new ... award includes a multi-site, five-year study and demonstrates a ... , "We are pleased that our partnership ...
... CHEYENNE, Wyo., Aug. 24 The Wyoming Department of Health ... program, a component of its innovative Total Health Record initiative. ... community and the Wyoming EqualityCare (EC) Healthy Together program, as ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/2008 ...
Cached Medicine Technology:Research-Based Biopharmaceutical Company Awards Trials to DATATRAK 2Research-Based Biopharmaceutical Company Awards Trials to DATATRAK 3Wyoming Department of Health's Pay-for-Participation Program Reports Positive Clinical Outcomes 2Wyoming Department of Health's Pay-for-Participation Program Reports Positive Clinical Outcomes 3
... Ergonomic Design for Unparalleled Comfort Pick ... Notice the balance. Notice the trigger and ejector ... Thats because our pipettors are ergonomically designed to ... hours of pipetting. Productivity In The Palm ...
... Design for Unparalleled Comfort Pick one of ... balance. Notice the trigger and ejector positionsright where ... our pipettors are ergonomically designed to help avoid ... pipetting. Productivity In The Palm Of Your ...
... The total ergonomic solution and best value ... feather touch action and ultra lightweight design ... tip ejection with long, lever tip ejector ... , Accepts universal tips or for greater ...
... Finnpipette BioControl multichannel has ... as the single channel ... fits all seven multichannel ... tip cone modules. Both ...
Medicine Products: