Navigation Links
New approach for treating recurrent prostate cancer on the horizon
Date:6/15/2009

TORONTOA new study shows that an alpha-particle emitting radiopeptideradioactive material bound to a synthetic peptide, a component of proteinis effective for treating prostate cancer in mice, according to researchers at SNM's 56th Annual Meeting in Toronto. The results could eventually result in a significant breakthrough in prostate cancer treatment, especially for patients whose cancer recurs after the prostate is removed.

"Our study shows that this novel form of treatment has the potential to target and destroy cancer cells with minimal damage to surrounding healthy tissue," said Damian Wild, University Hospital Basel, Basel, Switzerland, lead author of the study. "Eventually, this therapy could give hope to some of the hardest-to-treat prostate cancer patients and also could be applied to other types of cancer."

Every year, more than 186,000 men in the United States are newly diagnosed with prostate cancer. The most common types of treatment include surgical removal of some, or all, of the prostate, followed by radiation therapy. More than 30,000 men each year who have had their prostates removed experience recurrence of the cancer. In most of these cases, the disease cannot be localized and treated adequately with conventional treatments; therefore, a systemic treatment that efficiently kills small tumors is needed.

Because tumor cells readily bind with certain peptides, researchers have been able to develop highly specific radiopeptides that bind with tumor cells and treat them using specific therapeutic radioactive substances attached to the radiopeptide. Prostate cancer cellsand many other types of cancer cellshave an overabundance of gastrin-releasing peptide receptors, making the cancer a strong candidate for treatment with radiopeptides.

The study compared two different types of radiopeptides. One group of mice was injected with 213 Bi-DOTA-PESIN, which emits alpha particles that are effective at killing cancer cells. The other group was injected with beta-emitting 177 Lu-DOTA-PESIN, which are also effective in tumor cell-killing, but can also cause damage to nearby healthy cells. Alpha particles are able to kill cancer cells without damaging surrounding healthy tissue. A third group of mice received no treatment.

However, at the maximum tolerated dose, the alpha-emitting 213 Bi-DOTA PESIN was significantly more effective, tripling the survival rate of the mice that received the therapy. The results indicate that the alpha-emitting radiopeptide could provide a new approach for treating prostate cancer and eventually other types of cancer.


'/>"/>

Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. Health care incentive model offers collaborative approach
2. Free will takes flight: how our brains respond to an approaching menace
3. New approaches to reduce scarring
4. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
5. New Poll Shows Public Distrusts Flawed Healthcare Approach Favored by Governor and Speaker in AB 8
6. Nuclear medicine approach can be first choice for excluding pulmonary embolism in young women
7. Blue Cross Blue Shield of Michigan Offers New Approach to Customer Group Wellness
8. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
9. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
10. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
11. Potential new approach to treat cognitive impairments in schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... February 20, 2017 , ... Today, ... Biscom Document Router (BDR), the first IoT device from Biscom designed to deliver ... Biscom will debut BDR at HIMSS17 and will be conducting demonstrations ...
(Date:2/20/2017)... ... February 20, 2017 , ... Johns Hopkins All Children's Hospital celebrated a major ... ceremony on Friday marked the halfway point of construction and lifting of the final ... will serve as a center for innovation aimed at finding new discoveries and treatments ...
(Date:2/19/2017)... ... February 19, 2017 , ... Braun Industries will be participating ... Exposition, the event will take place February 23-25, 2017 at the Calvin L. Rampton ... Booth #909 with three new ambulances on display. , “JEMS is ...
(Date:2/18/2017)... Massachusetts (PRWEB) , ... February 17, 2017 , ... ... the leading source of disruptive innovation in the industry, according to the recent ... Reports are based on surveys of the NEJM Catalyst Insights Council, a qualified ...
(Date:2/18/2017)... , ... February 18, 2017 , ... ... provides the latest information and contact points to easily connect elderly veterans of ... assisted living, and elder-care funding. It also conveys material on this year's increase ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... 20, 2017 This report analyzes the worldwide markets ... provides separate comprehensive analytics for the US, Canada ... , Asia-Pacific , and Rest of ... Annual estimates and forecasts are provided for ... is provided for these markets. Market data and analytics are ...
(Date:2/20/2017)... , February 20, 2017 The ... available on AskLinkerReports.com is a comprehensive analysis of the PSA ... Oxygen Concentrators to definition, classification, application, and industry chain overview ... feasibility analysis, new project SWOT analysis, and investment return analysis ... ...
(Date:2/20/2017)... , Feb. 20, 2017   Orion Health ... Amadeus precision medicine platform to the Amazon ... manages over 110 million patient records globally. ... cloud-based, big data solutions built on modern, scalable technology," ... and Life Sciences. "The AWS Cloud gives healthcare companies ...
Breaking Medicine Technology: